Der experimentelle chemische Diabetes

Alloxan acts as a prooxidant only under reducing conditions: influence of melatonin

“…From data presented in figure 1B, a half-life of alloxan at 25°C and pH 7.2 can be calculated as 2-3 min. This value is in the same range as other data from literature [7,[19][20][21]. On the other hand, the increase of light absorption at 271 nm is probably connected with the formation of dialuric acid ( fig.…”

“…The diabetogenic intravenous (i.v.) dosage of alloxan for rats amounts to 25-60 mg of alloxan/kg body weight [20]. The blood volume of a Wistar rat with a body weight of 250 g is 10 ml [27].…”

Effect of Insulin and Experimental Diabetes mellitus on the Digestive-Absorptive Function of the Small Intestine

“…in doses between 50 and 75 mg/kg, will induce a severe, but non-ketotic dia betes mellitus in rats; doses above 75 mg/kg will also induce diabetic keto acidosis [29], The ¡3-cytotoxic effects of streptozotocin can completely be prevented in rats by administration of nicotinamide prior to or simultane ously with the injection of streptozotocin [65]. Streptozotocin produces dia betes more consistently than alloxan [29]. However, the first report on in creased intestinal sugar absorption in experimental diabetes mellitus was in pancreatectomized rats [57], Pauls and Drury reported higher glucose absorption coefficients in diabetic rats compared to controls [57]; the coeffi cient of absorption was low, however, in rats force-fed with glucose.…”

“…Most commonly used agents to induce experimental diabetes mellitus are the fi-cytotoxic drugs: alloxan and streptozotocin [29], Streptozotocin. in doses between 50 and 75 mg/kg, will induce a severe, but non-ketotic dia betes mellitus in rats; doses above 75 mg/kg will also induce diabetic keto acidosis [29], The ¡3-cytotoxic effects of streptozotocin can completely be prevented in rats by administration of nicotinamide prior to or simultane ously with the injection of streptozotocin [65]. Streptozotocin produces dia betes more consistently than alloxan [29].…”

Insulin binding and action in antibody-induced diabetes in the rat

“…The pharmacological substances, alloxan and streptozotocin, have acute toxic side effects which might also influence receptor regulation and/or insulin action [8].…”