Der Fr�hnachweis des Herzinfarktes durch Bestimmung der Wasserstoffionenkonzentration im Herzmuskel mit Indicatorpapier

Krug, A

doi:10.1007/bf00957656

Cited by 19 publications

(4 citation statements)

References 2 publications

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“…Observation of the blue border zone is in agreement with the findings of Krug (10,11). Comparison of areas showing tissue pH changes with those in which glycogen was depleted permits an explanation differing somewhat from that of Krug. As long as the excised heart was not frozen, the tissue pH of the undamaged myocardium containing glycogen decreased as a result of accumulation of acid end-products of postmortal anaerobic glycolysis.…”

Section: Discussionsupporting

confidence: 81%

“…A different opinion about the origin of the "blue" zone was propounded by Krug (10,11). According to him, the blue rim is alkaline and indicates early necrosis.…”

Section: Discussionmentioning

confidence: 97%

“…(i) Tissue pH was detected with the aid of the so-called "sandwich" technique (modified method of Krug [10,11]). The frozen histological section was mounted on a transparent layer of unbuffered dry polyacrylamide gel containing bromoxylenol blue.…”

Section: Methodsmentioning

confidence: 99%

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The border zone of the early myocardial infarction in dogs; its characteristics and viability

Sládek¹,

Filkuka²,

Dolezel³

et al. 1984

Basic Res Cardiol

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In open-chest dogs, the left anterior descending coronary artery was ligated for 150 min. The heart was semiserially cut on a cryomicrotome and areas of ischemic damage were visualized by means of glycogen depletion (PAS reaction) and tissue acidosis (a "sandwich" technique with pH indicator dispersed in a layer of gel). The extent of myocardial damage was determined morphometrically. The mass of the glycogen-depleted heart muscle was greater than the mass of the ischemic tissue detected by means of decreased pH (p less than 0.01). The border zone was characterized by glycogen depletion without acidosis. Circulation studies using intravital fluorescein staining have shown that perfusion is partially retained in the border zone; it is assumed that the hypoperfusion triggers glycogenolysis. Nevertheless, the level of perfusion suffices to wash out the acidic end products. Comparison of contrapulsation-treated dogs and untreated dogs shows that the amount of damaged tissue comprising the border zone can be reduced by this therapeutic intervention (p less than 0.02) - in contrast to the acidotic tissue, the amount of which is not significantly influenced. Therefore the border zone contains damaged but still viable muscle cells.

show abstract

Section: Discussionsupporting

confidence: 81%

“…A different opinion about the origin of the "blue" zone was propounded by Krug (10,11). According to him, the blue rim is alkaline and indicates early necrosis.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

The border zone of the early myocardial infarction in dogs; its characteristics and viability

Sládek¹,

Filkuka²,

Dolezel³

et al. 1984

Basic Res Cardiol

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show abstract

“…Changes of myocardial pH have been observed after various periods of local or total ischemia [4,5). Furthermore, many authors found that an artificiallyproduced acidosis or alkalosis can influence the contractile performance of the heart as well as the coronary blood flow [2,31.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Acid-Base Changes in the Dog Myocardium During Hypoxia and Local Ischemia, Measured by Means of Glass Micro-Electrodes

Benzing¹,

Gebert²,

Strohm³

1971

Cardiology

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Das Verhalten der Wasserstoffionenkonzentration [H+] im Herzmuskel und Änderungen der Kreatinphosphokinase (CPK) und Glutamatoxalacetattransaminase (GOT) im Serum nach permanentem und temporärem Koronararterienverschluß 106. Instabilität und Vascularisation langer Röhrenknochen im Experiment

Krug

Buchheit

1972

Chirurgisches Forum Für Experimentelle Und Klinische Forschung

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Der Fr�hnachweis des Herzinfarktes durch Bestimmung der Wasserstoffionenkonzentration im Herzmuskel mit Indicatorpapier

Cited by 19 publications

References 2 publications

The border zone of the early myocardial infarction in dogs; its characteristics and viability

The border zone of the early myocardial infarction in dogs; its characteristics and viability

Extracellular Acid-Base Changes in the Dog Myocardium During Hypoxia and Local Ischemia, Measured by Means of Glass Micro-Electrodes

Das Verhalten der Wasserstoffionenkonzentration [H+] im Herzmuskel und Änderungen der Kreatinphosphokinase (CPK) und Glutamatoxalacetattransaminase (GOT) im Serum nach permanentem und temporärem Koronararterienverschluß 106. Instabilität und Vascularisation langer Röhrenknochen im Experiment

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