Der normale histologische Bau und die Sklerose der Aortenklappen

Mönckeberg, J. G.

doi:10.1007/bf02041318

Cited by 116 publications

(24 citation statements)

References 3 publications

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“…The debate over the pathogenesis of non-rheumatic calcific aortic stenosis found another important step in the 1904 when Mönckeberg published his first description of the dystrophic calcification of the aortic valve [18].…”

Section: Epidemiology Historical Perspectivementioning

confidence: 99%

Degeneration of native and tissue prosthetic valve in aortic position: Do statins play an effective role in prevention?

Colli

Gherli

Mestres

et al. 2007

International Journal of Cardiology

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Section: Epidemiology Historical Perspectivementioning

confidence: 99%

Degeneration of native and tissue prosthetic valve in aortic position: Do statins play an effective role in prevention?

Colli

Gherli

Mestres

et al. 2007

International Journal of Cardiology

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“…The link between aortic valve accumulation of calcification (ie, anatomic lesion of the valve) and AS (ie, hemodynamic burden of the lesion) has been long demonstrated in autopsy studies, [19][20][21] even at a very early stage of the disease. 10 This anatomic link for AS calcification was confirmed in vivo casually during fluoroscopy 22 and more recently quantitatively by using CT in previous small studies.…”

Section: Avc-as Mechanismmentioning

confidence: 99%

Sex Differences in Aortic Valve Calcification Measured by Multidetector Computed Tomography in Aortic Stenosis

Aggarwal

Clavel

Messika–Zeitoun

et al. 2013

Circ: Cardiovascular Imaging

219

130

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A ortic stenosis (AS) is common in elderly people, affecting 2% of the population ≥65 years old and 4.6% of population ≥75 years old based on Doppler echocardiographic or community studies.1,2 Nowadays, the most common cause of AS is degenerative, and aortic valve calcification (AVC) is the intrinsic mechanism of valvular stiffening and obstruction. [3][4][5][6] Although degenerative AS has long been considered age related, recent studies have demonstrated that it is an active process involving biological pathways with many similarities to atherosclerosis. 7,8 Epidemiological studies identified similar risk factors for calcific AS and coronary atherosclerosis such as age, smoking, elevated cholesterol levels, diabetes mellitus, metabolic syndrome, hypertension, and increase in lipoprotein-a levels. 9 Male sex was also touted as an independent risk factor for AS similar to atherosclerosis, 9 but studies linking valve tissue alterations 10,11 and calcification to AS 12 have not differentiated between men and women. Moreover, studies of aortic valve weight as a surrogate for calcification load showed discordant results with regard to sex, 13,14 and clinically, guidelines do not differentiate between men and women for AS pathophysiology and management. 6 However, the analogy to atherosclerosis suggests that there may be important, yet thus far undefined, sex-related differences in the development of AVC and the transition to AS. This issue can now be analyzed because cardiac computed tomography (CT) provides accurate and reproducible quantification of AVC load, 15 and multidetector CT (MDCT) may prove to be a useful adjunct tool for the evaluation of AS severity. However, previous studies suggested a single set of cutoff values for detecting severe AS regardless of sex, 16 so the impact of sex on the relation between aortic cusp calcification measured by MDCT and hemodynamic severity of AS remains uncertain. The aim of the present study was to determine the differential physiological relationship between AVC Background-Aortic valve calcification (AVC) is the intrinsic mechanism of valvular obstruction leading to aortic stenosis (AS) and is measurable by multidetector computed tomography. The link between sex and AS is controversial and that with AVC is unknown. Methods and Results-We Conclusions-In Aggarwal et al Aortic Valve Calcification in Women 41load and AS hemodynamic severity between men and women. We hypothesized that women reach thresholds for severe AS for lower calcification loads than men and that when MDCT is used for the diagnosis of AS severity, criteria of AVC load would need to be adjusted specifically for each sex. Methods Study PopulationWe prospectively enrolled patients with at least mild calcific AS in whom we performed noncontrast MDCT scan for the evaluation of AVC and comprehensive transthoracic echocardiography within 90 Creatinine Clearance age k gPatients from the Bichat Hospital were enrolled in 2 ongoing prospective studies on aortic valve calcification/stenosis (COFRASA; www.clinica...

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“…There are similarities between the plaque of coronary atherosclerosis and initial lesions of CAVD, with presence of similar risk factors for both. 2 Monckeberg 3 described the dystrophic calcification of the aortic valve in 1904 as cause of nonrheumatic calcific AS. This article attempts to discuss the insights to debate whether CAVD is another face of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Calcific aortic valve disease: Is it another face of atherosclerosis?

Sathyamurthy

Alex

2015

Indian Heart Journal

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Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the elderly. As life expectancy increases, prevalence of CAVD is expected to rise. CAVD is characterized by progressive dystrophic calcification of aortic cusps. In the initial stages, the pathogenesis is similar to atherosclerosis, characterized by basement membrane disruption, inflammation, cell infiltration, lipid deposition, and calcification. Presence of osteopontin in calcified aortic valves suggests pathological calcification and bone formation in these calcified valves. Historical, experimental, genetic, and clinical evidences suggest that CAVD and atherosclerosis share the same pathological sequences with common risk factors. Understanding the two faces of atherosclerosis, the vascular and valvular, will help us to prevent progression of aortic sclerosis to aortic stenosis, by controlling modifiable risk factors and by initiating statin therapy in them. However, the knowledge about these preventive measures and drugs is scanty. In this review article, an attempt is made to unfurl the relation between atherosclerosis and CAVD.

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Der normale histologische Bau und die Sklerose der Aortenklappen

Abstract: XIX. ])er normale histologische Bau und die Sklerose der Aortenklappen.

Cited by 116 publications

References 3 publications

Degeneration of native and tissue prosthetic valve in aortic position: Do statins play an effective role in prevention?

Degeneration of native and tissue prosthetic valve in aortic position: Do statins play an effective role in prevention?

Sex Differences in Aortic Valve Calcification Measured by Multidetector Computed Tomography in Aortic Stenosis

Calcific aortic valve disease: Is it another face of atherosclerosis?

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