Der p 23: Clinical Relevance of Molecular Monosensitization in House Dust Mite Allergy

Semedo, Filipa; Dorofeeva, Yulia; Pires, Ana Paula; Tomáz, Elza; Taborda-Barata, Luís; Inácio, Filipe; Valenta, Rudolf

doi:10.18176/jiaci.0392

Cited by 15 publications

(11 citation statements)

References 7 publications

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“…Resch and colleagues saw 3.8%, 10 and Posa and colleagues 5.9% 11 . Thus, several studies confirm Der p 23 as a significant sensitization source in its own right 39,40 …”

Section: Discussionmentioning

confidence: 87%

Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA

Muddaluru

Valenta

Vrtala

et al. 2021

Allergy

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Background Sensitization to house dust mite (HDM) is a leading cause of allergic rhinitis and asthma. Despite more than 30 HDM‐derived allergens having been identified to date, specific therapeutic approaches do not yet take into account the local sensitization profiles of patients. This study aimed to identify patterns of HDM sensitization in HDM‐allergic adults living in distinct geographic areas, to inform the development of targeted diagnostic and therapeutic tools. Methods Serum samples from 685 HDM‐allergic subjects from Canada, Europe, South Africa, and the USA were tested for levels of IgE specific for 17 micro‐arrayed HDM allergens by ImmunoCAP Immuno Solid‐phase Allergen Chip (ISAC) technology. Results The results confirmed significant geographical variability in sensitization patterns and levels of IgE. In all areas, the major sensitizers were the group 1 and group 2 allergens and Der p 23. Der p 23 was a frequent sensitizer: 64% of the subjects had IgE specific for Der p 23, and 2.3% were monosensitized to it. In South Africa, Der p 23 was the dominant HDM allergen (86% prevalence) and Der p 7 achieved major allergen status (56%). IgE sensitization to HDM was influenced by asthmatic status, levels of allergen exposure, age, race‐ethnicity and smoking status, but not by BMI. Conclusion Sensitization profiles to HDM allergens differ considerably among distinct geographic areas, with Der p 7 and Der p 23 being major sensitizers in South Africa. Such heterogeneity should be taken into account in the diagnosis and treatment of HDM‐allergic patients.

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“…Resch and colleagues saw 3.8%, 10 and Posa and colleagues 5.9% 11 . Thus, several studies confirm Der p 23 as a significant sensitization source in its own right 39,40 …”

Section: Discussionmentioning

confidence: 87%

Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA

Muddaluru

Valenta

Vrtala

et al. 2021

Allergy

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“…Component resolved diagnostics (CRD) makes it possible for precision medication and individual management, while Der p 1, Der p 2, Der p 23, Der f 1 and Der f 2 are considered to be the main HDM allergens [3–5 ]. Allergen immunotherapy (AIT), including mainly subcutaneous immunotherapy (SCIT) and sublingual immunotherapy, is the only available etiological treatment for AR.…”

Section: Figurementioning

confidence: 99%

Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients

Huang

Lou

et al. 2019

Clin Transl Allergy

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Data regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed up to assess serum levels of sIgE and sIgG4 to HDM components. The study showed that Der p1, p2, p23, Der f1 and f2, are important sensitizing components of HDM, of which Der p1 appears to be the most clinically relevant allergenic component for effective AIT.

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“…DN group is a very significant value to consider in two fundamental aspects: initiation of AIT or inclusion in clinical trials for this treatment. This double negative group to IgEDerp1 and IgEDerp2 is sensitized to minority allergens 21 . DN group patient’s shows a low response in the production of sIgE for the complete extract of Dptr , therefore it may influence its use as an AIT response biomarker 22 .…”

Section: Discussionmentioning

confidence: 98%

“…It appears that in the absence of Derp1 sensitization, the immune system responds to Derp23 as an allergen present in faeces. Patients sensitized only to Derp1 or only Derp2, both constitute a small number of the sample (16%) 14 , 21 . In our results, in the group double negative to IgEDerp1 and IgEDerp2 (DN), the 75% of them are IgEDerp23 positive, with low values of sIgE with mean 0.89 ± 2.01 KU A /L and median 0.08 (7.60–0.0) KU A /L.…”

Section: Discussionmentioning

confidence: 99%

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

Letrán¹,

García

Espinazo-Romeu

et al. 2021

Sci Rep

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Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KUA/L for D. pteronyssinus sIgE gave us a sensitivity and specificity of 0.882 and 0.985, respectively, to double negative IgE nDer p 1 and IgE rDer p 2 group. Despite positive SPT and sIgE to D. pteronyssinus, 17% of the studied population is IgE nDer p 1 and IgE rDer p 2 double negative, with a cut-off value of 2.18 KU/L, which is very relevant for taking of decisions in prescription of AIT. The double positive population sIgE nDer p 1 and IgE rDer p 2 is associated with asthma compared to the other groups and this does not seem to be influenced by IgE rDer p 23.

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Der p 23: Clinical Relevance of Molecular Monosensitization in House Dust Mite Allergy

Cited by 15 publications

References 7 publications

Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA

Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA

Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

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