Derangement of the E-cadherin/catenin complex is involved in transformation of differentiated to anaplastic thyroid carcinoma

Wiseman, Sam M.; Masoudi, Hamid; Niblock, Paddy; Turbin, Dmitry; Rajput, Ashish; Hay, John; Filipenko, Douglas; Huntsman, David; Gilks, Blake

doi:10.1016/j.amjsurg.2006.02.005

Cited by 44 publications

(27 citation statements)

References 31 publications

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“…The findings suggested that the expression of Ecadherin/β-catenin was significantly associated with the growth and invasion of the sebaceous adenocarcinomas. It agreed with the studies mentioned above which showed an association between E-cadherin/β-catenin complex and other major carcinomas, such as rectosigmoid cancers, anaplastic thyroid carcinoma, oral squamous cell carcinomas, pulmonary neuroendocrine tumors and hepatocellular carcinoma, to mention a few only [18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 91%

E-cadherin and β-catenin expression in sebaceous eyelid adenocarcinomas

Zhang

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Sebaceous eyelid adenocarcinomas showed a decrease in the membranous expression of E-cadherin and of β-catenin. These changes were associated with poor tumor differentiation and an increase in the tumor infiltration and inflammation, pointing at a potential role of a low E-cadherin and low β-catenin expression for poor prognosis of sebaceous eyelid adenocarcinomas. Correspondingly, the cell proliferation index and the expression of E-cadherin were inversely correlated with each other. The findings suggest that the immunohistochemical detection of a low E-cadherin and low β-catenin expression may help in the examination and staging of sebaceous eyelid adenocarcinomas.

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Section: Discussionsupporting

confidence: 91%

E-cadherin and β-catenin expression in sebaceous eyelid adenocarcinomas

Zhang

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…Thyroglobluin, p53 and K i -67 results were consistent with the findings of prior studies that show overexpression of K i -67 and p53 and underexpression of thyroglobulin in ATC. [5][6][7][12][13][14][15][16][17] As an important tumor suppressor gene, p53 is found to be mutated in many other human malignant tumors. It serves as both an inhibitor of G 1 phase as well as a pro-apoptotic molecular when the proper cellular conditions are met.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of cell cycle mediator protein expression patterns in anaplastic and papillary thyroid carcinoma

Evans

Crist

Durvesh

et al. 2012

Cancer Biology & Therapy

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“…There is decreased expression of E-cadherin and bcatenin by the anaplastic tumors when compared with the differentiated thyroid tumors from which they evolved and derangement of the E-cadherin/catenin complex is associated with the transformation of differentiated into ATC [29].…”

Section: Cyclins E-cadherin and B-cateninmentioning

confidence: 99%