Derangement of the hypothalamic GnRH pulse generator in women with epilepsy

R, Meo; Bilo, Leonilda; Nappi, Carmine; Tommaselli, A; Valentino, Rossella; Nocerino, C.; Striano, Salvatore; Buscaino, G A

doi:10.1016/s1059-1311(05)80134-7

Cited by 50 publications

(23 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The in vitro data are obtained in precisely defined conditions whereas the in vivo results are likely to be compounded by extraneous factors. For instance, it has been shown that pilocarpine induction of epilepsy in rats leads to specific increases of testosterone, among other ovarian steroids that remain unaffected [20], and that the frequency of LH pulses is increased in epilepsy [21]. Additionally, it has been reported that VPA treatment of epileptic patients results in increased blood levels of insulin, possibly due to lower metabolism of insulin [22].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells

Fisseha

Towns

Harada

et al. 2009

Endocr

View full text Add to dashboard Cite

The objective of the study was to evaluate the effect of valproic acid (VPA) on ovarian androgen biosynthesis in primary cultures of theca-interstitial (T-I) cells isolated from rat ovaries. Ovarian T-I cells were cultured with VPA in the presence or absence of hCG. VPA did not increase basal or hCG-stimulated androgen synthesis when added to primary cultures of T-I cells. However, the addition of VPA caused a marked concentration-dependent inhibitory effect on hCG-stimulated androstendione synthesis. Treatment of T-I cells with 8-Bromo-cAMP resulted in a marked increase in the production of androstenedione, and VPA inhibited this stimulatory effect, suggesting that the mechanism of VPA's inhibitory effect on androstenedione production occurs at a step after second messenger activation. Treatment of T-I cells with hCG resulted in a significant increase in the mRNA expression of steroidogenic enzymes CYP17A1 and 17β-hydroxysteroid dehydrogenase. Addition of VPA sharply blunted the stimulatory effect of hCG, reducing the mRNA expression of the steroidogenic enzymes to basal levels. In conclusion, VPA exerts an inhibitory effect on hCGstimulated androgen synthesis in rat T-I cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells

Fisseha

Towns

Harada

et al. 2009

Endocr

View full text Add to dashboard Cite

show abstract

“…Disrupted release of pituitary hormones is seen in women and men with epilepsy. 21–26 The abnormal release of follicle-stimulating hormone (FSH) and luteinising hormone (LH) follows dysfunction of gonadotropin-releasing hormone (GnRH) cells in the hypothalamus. GnRH, which is produced by a small number of cells located primarily in the preoptic area of the hypothalamus, controls gonadal activity via pulsatile secretion and stimulation of pituitary hormone release.…”

Section: Causes Of Reproductive Dysfunction In Epilepsymentioning

confidence: 99%

Neuroendocrine considerations in the treatment of men and women with epilepsy

Harden

Pennell

2013

The Lancet Neurology

118

View full text Add to dashboard Cite

Complex, multidirectional interactions between hormones, seizures, and the medications used to control them can present a challenge for clinicians treating patients with epilepsy. Many hormones act as neurosteroids, modulating brain excitability via direct binding sites. Thus, changes in endogenous or exogenous hormone levels can affect the occurrence of seizures directly as well as indirectly through pharmacokinetic effects that alter the concentrations of antiepileptic drugs. The underlying structural and physiological brain abnormalities of epilepsy and the metabolic activity of antiepileptic drugs can adversely affect hypothalamic and gonadal functioning. Knowledge of these complex interactions has increased and can now be incorporated in meaningful treatment approaches for men and women with epilepsy.

show abstract

“…Neben den epileptischen Anfällen scheinen die interiktalen zentralnervö-sen Erregungsstörungen eine Dysbalance der Ausschüttung von regulärem LH und follikelstimulierendem Hormon (FSH) zu provozieren [7,20]. Demzufolge propagieren gestörte ZNS-Erregungsabläufe, v. a. aus temporolimbischen Arealen, zu hypothalamischen Regulationszentren und interferieren mit der neuronalen Aktivität des hypothalamischen Pulsgenerators, der die GnRHSekretion steuert.…”

Section: Hypothalamische Funktionsstörungunclassified

Hormon- und Sexualstörungen bei Epilepsie

Luef

2018

Z. Epileptol.

View full text Add to dashboard Cite

Derangement of the hypothalamic GnRH pulse generator in women with epilepsy

Cited by 50 publications

References 69 publications

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells

Neuroendocrine considerations in the treatment of men and women with epilepsy

Hormon- und Sexualstörungen bei Epilepsie

Contact Info

Product

Resources

About