Dercum's disease: a rare and underdiagnosed disease

Molina, Juliana D'Andrea; Nai, Gisele Alborghetti; Andrade, Tatiana Cristina Pedro Cordeiro de; Abreu, Marilda Aparecida Milanêz Morgado de

doi:10.1590/abd1806-4841.20198231

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Type 3 localized nodular: painful adipose tissue exclusively within and around lipomas. Lastly, type 4 juxta-articular: deposition of painful solitary fat in the proximity of large joints [ 1 , 7 ]. This case matched with Dercum's disease type 2 as he is suffering from painful lipomas.…”

Section: Discussionmentioning

confidence: 99%

Dercum's Disease: A Rare Disease of Painful Fatty Lumps

Mosbeh,

Almutairi,

Albazzali

2023

Cureus

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Dercum's disease is a rare and poorly understood condition characterized by painful subcutaneous adipose tissue growth that can occur anywhere beneath the skin surface. We present the case of a 27-year-old man with no significant medical history who had been experiencing painful subcutaneous nodules for two years. Skin biopsy revealed the proliferation of mature adipocytes that were surrounded by fibrous septa. There are currently no treatments approved by the US Food and Drug Administration for Dercum's disease, and the effectiveness of treatments that have been attempted is variable.

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Section: Discussionmentioning

confidence: 99%

Dercum's Disease: A Rare Disease of Painful Fatty Lumps

Mosbeh,

Almutairi,

Albazzali

2023

Cureus

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“…Based on in vitro and in vivo preclinical studies, the putative mechanism of action of RZL-012 seems to operate through induction of significant fat cell necrosis after a single injection with transient side effects, mostly at the injected area. An open label Phase 2a trial in 6 Dercum's disease patients 1,2 was undertaken to confirm initial safety and efficacy. Patients were dosed once by injecting the compound into painful lipomas.…”

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confidence: 99%