Deregulation of microRNA expression in thyroid tumors

Yuan, Ziming; Yang, Zhili; Zheng, Qi

doi:10.1631/jzus.b1300192

Cited by 20 publications

(14 citation statements)

References 92 publications

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“…Several studies have evaluated the miR profiles of thyroid carcinomas in attempts to find possible diagnostic and prognostic applications [29,30]. Generally, miR downregulation is the most common pattern in thyroid cancer cells [28].…”

Section: Microrna Deregulations In Thyroid Tumorsmentioning

confidence: 99%

“…The pathobiology of anaplastic thyroid cancer (ATC) is associated with the downregulation of many miRs in contrast to other thyroid carcinomas of follicular cell origin [29]. Some ATC cases indicate the early event in thyroid carcinogenesis being abnormally regulated as far back as in differentiated thyroid cancer (e.g.…”

Section: Microrna Deregulations In Thyroid Tumorsmentioning

confidence: 99%

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Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration

2015

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Objective: MicroRNAs (miRs) are noncoding, single-stranded regulatory RNA molecules involved in the posttranscriptional regulation of gene expression. They control the development and maintenance of the diverse cellular processes including proliferation, differentiation, motility and apoptosis. Expression of miRs is tissue-specific and each alteration of the tissue miR profile is associated with a distinct disease status. Study Design: We reviewed the literature on the expression of miRs in thyroid tumors, focusing on methodology and diagnostic and prognostic output. Separately, we analyzed 11 studies on miR profiles in thyroid cytological material. Results: Numerous studies have evaluated the miR profiles of thyroid tumors in an attempt to find a possible diagnostic and prognostic role. Both downregulation and upregulation of numerous miRs was found, but differences between the surgical pathology specimens and corresponding fine-needle aspirates in the expression of the same miRs were also reported. Conclusions: The results from surgically resected material cannot be extrapolated into preoperative use without validation. For diagnostic use, the strong overlap between follicular adenoma and follicular carcinoma miR profiles is challenging. In summary, miR-221 and miR-222 are consistently upregulated in different types of thyroid carcinomas and might be used as markers of malignancy.

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Section: Microrna Deregulations In Thyroid Tumorsmentioning

confidence: 99%

Section: Microrna Deregulations In Thyroid Tumorsmentioning

confidence: 99%

Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration

2015

View full text Add to dashboard Cite

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“…Four were down-regulated (miR-122, miR-183, miR-149, and miR514a) and seven were up-regulated (miR-146b, miR-222, miR-221, miR-10b, miR-199a/miR-199b, miR-203 and miR-32) [23,24]. MiR-221, miR-222 and miR-146b were also up-regulated in experimental models of thyroid tumorigenesis [16,25]. Increasing evidence shows that cancer-derived exosomes contain miRNAs, which regulate the proliferation of recipient cells.…”

Section: Discussionmentioning

confidence: 99%

The Stature of Human Thyroid Cancer Related to Over Expressed mir-221 and mir-146b

Molaei¹,

Meidanchi²,

Mirzaahmadi³

2017

J Mol Biomark Diagn

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“…Furthermore, abnormality of miRNAs may disorder related genes and other toxicities (Yuan et al, 2014). Lecellier et al (2005) discovered that miR-196 is related to development and can regulate the HoxB8 gene in mice.…”

Section: Discussionmentioning

confidence: 99%

Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways

Dai

Zhao

et al. 2014

J. Zhejiang Univ. Sci. B

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RNA interference (RNAi) is considered as a potential modality for clinical treatment and anti-virus animal breeding. Here, we investigate the feasibility of inhibiting classical swine fever virus (CSFV) replication by short hairpin RNA (shRNA) in vitro and in vivo. We generate four different shRNA-positive clonal cells and two types of shRNA-transgenic pigs. CSFV could be effectively inhibited in shRNA-positive clonal cells and tail tip fibroblasts of shRNA-transgenic pigs. Unexpectedly, an early lethality due to shRNA is observed in these shRNA-transgenic pigs. With further research on shRNA-positive clonal cells and transgenic pigs, we report a great induction of interferon (IFN)-responsive genes in shRNA-positive clonal cells, altered levels of endogenous microRNAs (miRNA), and their processing enzymes in shRNA-positive cells. What is more, abnormal expressions of miRNAs and their processing enzymes are also observed in the livers of shRNA-transgenic pigs, indicating saturation of miRNA/shRNA pathways induced by shRNA. In addition, we investigate the effects of shRNAs on the development of somatic cell nuclear transfer (SCNT) embryos. These results show that shRNA causes adverse effects in vitro and in vivo and shRNAinduced disruption of the endogenous miRNA pathway may lead to the early lethality of shRNA-transgenic pigs. We firstly report abnormalities of the miRNA pathway in shRNA-transgenic animals, which may explain the early lethality of shRNA-transgenic pigs and has important implications for shRNA-transgenic animal preparation.

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Deregulation of microRNA expression in thyroid tumors

Cited by 20 publications

References 92 publications

Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration

Pathobiology of MicroRNAs and Their Emerging Role in Thyroid Fine-Needle Aspiration

The Stature of Human Thyroid Cancer Related to Over Expressed mir-221 and mir-146b

Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways

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