Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration, Invasion, and Cell Proliferation in Breast Cancer

Moorthy, Rajesh Kannan; Srinivasan, Chandhru; Kannan, M.D.; Arockiam, Antony Joseph Velanganni

doi:10.1007/s12010-023-04375-3

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…[ 103 ] However, Moorthy et al, 2023 recently showed that miR‐375 targeted and inhibited the transcriptional factor, homeobox protein A5 (HOXA5), while promoting cell proliferation, invasion, and cell migration. [ 104 ] This indicated the duality of miR‐375 as a tumor suppressor miRNA and an oncomir of breast cancer. All these studies reveal duality in functions of miRNAs as oncomirs and as tumor suppressors hence more accurate studies are needed to understand pathological functions in breast cancer disease, to deliver discernable therapy targets.…”

Section: Cellular and Exosomal Mirna In Breast Cancermentioning

confidence: 99%

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Zablon,

Desai,

Dellinger

et al. 2024

Advanced Biology

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Breast cancer accounts for the highest cancer cases globally, with 12% of occurrences progressing to metastatic breast cancer with a low survival rate and limited effective early intervention strategies augmented by late diagnosis. Moreover, a low concentration of prognostic and predictive markers hinders disease monitoring. Circulating and exosomal microRNAs (miRNAs) have recently shown a considerable interplay in breast cancer, standing out as effective diagnostic and prognostic markers. The primary functions are as gene regulatory agents at the genetic and epigenetic levels. An array of dysregulated miRNAs stimulates cancer‐promoting mechanisms, activating oncogenes and controlling tumor‐suppressing genes and mechanisms. Exosomes are vastly studied extracellular vesicles, carrying, and transporting cargo, including noncoding RNAs with premier roles in oncogenesis. Translocation of miRNAs from the circulation to exosomes, with RNA‐binding proteins in stress‐induced conditions, has shown significant cooperation in function to promote breast cancer. This review examines cellular and exosomal miRNA biogenesis and loading, the clinical implications of their dysregulation, their function in diagnosis, prognosis, and prediction of breast cancer, and in regulating cancer signaling pathways. The influence of cellular and exosomal miRNAs presents clinical significance on breast cancer diagnosis, subtyping, staging, prediction, and disease monitoring during treatment, hence a potent marker for breast cancer.

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Section: Cellular and Exosomal Mirna In Breast Cancermentioning

confidence: 99%

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Zablon,

Desai,

Dellinger

et al. 2024

Advanced Biology

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show abstract

“…Additionally, miR-375 was upregulated in HER2− patients and patients who did not achieve pCR ( p = 0.006). A known target of miR-375 is HOXA5, whose underexpression promotes the evasion of apoptosis and stimulates cell proliferation and migration in BC [ 121 ]. The substantial downregulation of let-7g was also observed in patients without pCR.…”

Section: Circulating Mirnas As Indicators Of Clinical Response To Nat...mentioning

confidence: 99%

Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

Ruiz-Manriquez,

Villarreal-Garza,

Benavides-Aguilar

et al. 2023

IJMS

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Breast cancer (BC) is a leading cause of cancer-related deaths among women worldwide. Neoadjuvant therapy (NAT) is increasingly being used to reduce tumor burden prior to surgical resection. However, current techniques for assessing tumor response have significant limitations. Additionally, drug resistance is commonly observed, raising a need to identify biomarkers that can predict treatment sensitivity and survival outcomes. Circulating microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and have been shown to play a significant role in cancer progression as tumor inducers or suppressors. The expression of circulating miRNAs has been found to be significantly altered in breast cancer patients. Moreover, recent studies have suggested that circulating miRNAs can serve as non-invasive biomarkers for predicting response to NAT. Therefore, this review provides a brief overview of recent studies that have demonstrated the potential of circulating miRNAs as biomarkers for predicting the clinical response to NAT in BC patients. The findings of this review will strengthen future research on developing miRNA-based biomarkers and their translation into medical practice, which could significantly improve the clinical management of BC patients undergoing NAT.

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Research Hotspots and Development Trend of microRNA-375 in Hepatocellular Carcinoma—Based on Bibliometric and Visualization Analysis

杜

2023

ACM

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Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration, Invasion, and Cell Proliferation in Breast Cancer

Cited by 4 publications

References 68 publications

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis

Exploring the Potential Role of Circulating microRNAs as Biomarkers for Predicting Clinical Response to Neoadjuvant Therapy in Breast Cancer

Research Hotspots and Development Trend of microRNA-375 in Hepatocellular Carcinoma—Based on Bibliometric and Visualization Analysis

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