Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II.<i>In vivo</i>studies

Uth, Kristin; Sleigh, Roger

doi:10.1080/13102818.2014.925298

Cited by 20 publications

(16 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Cancer [breast (Filipski et al, 2006;Gautherie & Gros, 1977;Gautherie et al, 1990;Haus & Smolensky, 2013;Rybnikova et al, 2015;Smolensky et al, 1974;Uth & Sleigh, 2014), prostate (Rybnikova et al, 2016), colorectal (Schernhammer et al, 2003)] -Hand, foot and mouth disease (Zhu et al, 2015) -Post-operative state (Farr et al, 1988;Gögenur, 2010;Gögenur et al, 2007), especially with propofol anesthesia (Dispersyn et al, 2008(Dispersyn et al, , 2009) -ICU outcome (Chan et al, 2012;Leyden et al, 2015).…”

Section: Discussionmentioning

confidence: 97%

“…ALAN is viewed today as a major threat to human health and well-being. Epidemiologic, clinical and laboratory animal investigations reveal evidence of increased risk for a broad array of medical conditions, including obesity; metabolic syndrome; diabetes; hypertension; cardiovascular disease; and breast, prostate, colorectal and other cancers (Arble et al, 2015;Cho et al, 2015;Cuesta et al, 2016;Haus & Smolensky, 2013;Johnston et al, 2016;Maury et al, 2014;Reitz & Martino, 2015;Rybnikova et al, 2016;Schernhammer et al, 2003;Smolensky et al, 2015a;Stevens & Zhu, 2015;Stevens et al, 2014;Uth & Sleigh, 2014;Van Cauter et al, 2008). The hypothesized mechanism is ALAN-induced alteration of the CTS, including the 24 h sleep/wake cycle.…”

mentioning

confidence: 93%

See 1 more Smart Citation

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky

Hermida

Reinberg

et al. 2016

Chronobiology International

155

View full text Add to dashboard Cite

Biological processes are organized in time as innate rhythms defined by the period (τ), phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level. The human time structure in its entirety is comprised of ultradian (τ < 20 h), circadian (20 h > τ < 28 h) and infradian (τ > 28 h) bioperiodicities. The circadian time structure (CTS) of human beings, which is more complicated than in lower animals, is orchestrated and staged by a brain central multioscillator system that includes a prominent pacemaker - the suprachiasmatic nuclei of the hypothalamus. Additional pacemaker activities are provided by the pineal hormone melatonin, which circulates during the nighttime, and the left and right cerebral cortices. Under ordinary circumstances this system coordinates the τ and Φ of rhythms driven by subservient peripheral cell, tissue and organ clock networks. Cyclic environmental, feeding and social time cues synchronize the endogenous 24 h clocks and rhythms. Accordingly, processes and functions of the internal environment are integrated in time for maximum biological efficiency, and they are also organized and synchronized in time to the external environment to ensure optimal performance and response to challenge. Artificial light at night (ALAN) exposure can alter the CTS as can night work, which, like rapid transmeridian displacement by air travel, necessitates realignment of the Φ of the multitude of 24 h rhythms. In 2001, Stevens and Rea coined the phrase "circadian disruption" (CD) to label the CTS misalignment induced by ALAN and shift work (SW) as a potential pathologic mechanism of the increased risk for cancer and other medical conditions. Current concerns relating to the effects of ALAN exposure on the CTS motivated us to renew our long-standing interest in the possible role of CD in the etiopathology of common human diseases and patient care. A surprisingly large number of medical conditions involve CD: adrenal insufficiency; nocturia; sleep-time non-dipping and rising blood pressure 24 h patterns (nocturnal hypertension); delayed sleep phase syndrome, non-24 h sleep/wake disorder; recurrent hypersomnia; SW intolerance; delirium; peptic ulcer disease; kidney failure; depression; mania; bipolar disorder; Parkinson's disease; Smith-Magenis syndrome; fatal familial insomnia syndrome; autism spectrum disorder; asthma; byssinosis; cancers; hand, foot and mouth disease; post-operative state; and ICU outcome. Poorly conceived medical interventions, for example nighttime dosing of synthetic corticosteroids and certain β-antagonists and cyclic nocturnal enteral or parenteral nutrition, plus lifestyle habits, including atypical eating times and chronic alcohol consumption, also can be causal of CD. Just as surprisingly are the many proven chronotherapeutic strategies available today to manage the CD of several of these medical conditions. In clinical medicine, CD seems to be a common, yet mostly unrecognized, pathologic mechanism of human disease as are the many effective chronotherapeutic int...

show abstract

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 93%

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky

Hermida

Reinberg

et al. 2016

Chronobiology International

155

View full text Add to dashboard Cite

show abstract

“…As such, circadian problems are often a marker of a number of diseases. Furthermore, deterioration of the 24-h rhythm increases the risk for the development or exacerbation not only of neurodegenerative disease, but also some cancers, depression, obesity, cardiovascular disease, and sleep disorders (Baron and Reid 2014;Uth and Sleigh 2014;Alibhai et al 2015;Saini et al 2015). Altogether, it is clear that daily oscillations in physiology, behavior, and motivation are regulated by the circadian system.…”

Section: Amplitude Of Scn Oscillationmentioning

confidence: 98%

Circadian Insights into Motivated Behavior

Antle

Silver

2015

Current Topics in Behavioral Neurosciences

View full text Add to dashboard Cite

For an organism to be successful in an evolutionary sense, it and its offspring must survive. Such survival depends on satisfying a number of needs that are driven by motivated behaviors, such as eating, sleeping, and mating. An individual can usually only pursue one motivated behavior at a time. The circadian system provides temporal structure to the organism's 24 hour day, partitioning specific behaviors to particular times of the day. The circadian system also allows anticipation of opportunities to engage in motivated behaviors that occur at predictable times of the day. Such anticipation enhances fitness by ensuring that the organism is physiologically ready to make use of a time-limited resource as soon as it becomes available. This could include activation of the sympathetic nervous system to transition from sleep to wake, or to engage in mating, or to activate of the parasympathetic nervous system to facilitate transitions to sleep, or to prepare the body to digest a meal. In addition to enabling temporal partitioning of motivated behaviors, the circadian system may also regulate the amplitude of the drive state motivating the behavior. For example, the circadian clock modulates not only when it is time to eat, but also how hungry we are. In this chapter we explore the physiology of our circadian clock and its involvement in a number of motivated behaviors such as sleeping, eating, exercise, sexual behavior, and maternal behavior. We also examine ways in which dysfunction of circadian timing can contribute to disease states, particularly in psychiatric conditions that include adherent motivational states.

show abstract

“…Since DNA damage is capable of rese ng the circadian clock, it is quite possible that the disrup on of the physiological circadian rhythm following the damaging event may affect func oning of the system for assessment of the severity of DNA damage. Damaged cells deficient in core clock proteins, such as Per1 may be prone to judging the damage they have sustained as severe enough to trigger apoptosis, whereas wild type cells may assess the same amount of DNA damage as milder and possibly reparable [261].…”

Section: Genotype-phenotype Correlations For Mutations and Polymorphimentioning

confidence: 99%

DNA damage and the circadian clock

Chakarov¹,

Petkova²,

Russev³

et al. 2014

Biodiscovery

View full text Add to dashboard Cite

The role of the circadian clock has already been demonstrated for virtually all physiological processes, but it was only recently shown that cells were more sensi ve to DNA damage at specific mes of the day; that the peak of synthesis of mRNA and proteins of genes coding for products involved directly or indirectly in DNA repair was differen ally med in different ssues; and that the growth of some types of cancer followed a circadian pa ern. The paper reviews the specifici es of the clockwork mechanism in living cells associated with repair of DNA damage with regards to its role in ageing and carcinogenesis. The role of heritable polymorhisms and soma c muta ons in the risk for development of common diseases (cancer, but also other types of diseases and condi ons, such as obesity and metabolic syndrome), their course and the possible outcomes is reviewed in animal models and in man. The circadian oscilla ons in the levels of major proteins of DNA-damage related signalling and DNA repair are discussed in rela on to differen al mechanisms of defence against genotoxic damage. The paper outlines the modern concept of 'chronotherapy' -that is, an cancer therapy administered at specific mes of the day/ night cycle that could be associated with be er outcomes in some pa ents and analyses the individual variance in the tolerability of chronotherapy vs. maximum-dose an cancer therapy.Cita on: Chakarov S, Petkova R, Russev GCh, Zhelev N. DNA damage and the circadian clock.

show abstract

Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part II.In vivostudies

Cited by 20 publications

References 94 publications

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Circadian Insights into Motivated Behavior

DNA damage and the circadian clock

Contact Info

Product

Resources

About