Derivation and Validation of a Diagnostic Prediction Tool for Interstitial Lung Disease

Pugashetti, Janelle Vu; Kitich, Aleksander; Alqalyoobi, Shehabaldin; Maynard-Paquette, A.-C.; Pritchard, David; Graham, Julia; Boctor, Noelle; Kulinich, Andrea G.; LaFond, Elyse; Foster, Elena; Mendez, Cesar; Choudhry, Saad; Chalaoui, J; Morisset, Julie; Kadoch, Michel; Oldham, Justin M.

doi:10.1016/j.chest.2020.02.044

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Nonetheless, we tried to exclude possible ILD cases by adapting spirometry results to eliminate confounding factors as much as possible. Pulmonary function tests are helpful in diagnosing and characterizing ILD 33 . FEV1/FVC ratio and percentage predicted FVC are two major determinants of pulmonary disease on the pulmonary function test.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary function tests are helpful in diagnosing and characterizing ILD. 33 FEV1/FVC ratio and percentage predicted FVC are two major determinants of pulmonary disease on the pulmonary function test. FEV 1 /FVC ratio over 0.7 or percentage predicted FVC under 80% indicate the possibility of mixed pattern and restrictive pattern pulmonary disease.…”

Section: Discussionmentioning

confidence: 99%

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Clinical implication of interstitial lung abnormality in elderly patients with early‐stage non‐small cell lung cancer

et al. 2022

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Background Interstitial lung abnormality (ILA) is closely related to lung cancer. This study aimed to assess whether the presence of ILA is associated with the clinicoradiological features of elderly patients (≥70 years) with early‐stage non‐small cell lung cancer (NSCLC). Methods Elderly patients who underwent surgical resection for stage I or II NSCLC with preserved lung function between 2012 and 2019 were retrospectively identified. ILA was evaluated using a three‐point scale. Univariate analyses were performed for clinicoradiological features based on the presence of ILA. Logistic and linear regression analyses were performed for cancer staging and tumor size, respectively. Results A total of 254 patients were evaluated. The presence of ILA (score = 2) was significantly associated with male sex, current or former smoker status, higher pack‐years of smoking, low forced expiratory volume in one second/forced vital capacity ratios and diffusing capacity of the lung for carbon monoxide, and presence of emphysema (≥5%). Tumor characteristics, such as lower lobe and outer one‐third location, squamous cell carcinoma, and higher cancer stage (stage II) were significantly associated with ILA. The presence of ILA independently predicted a higher cancer stage (adjusted odds ratio, 1.81; 95% confidence interval, 1.10–2.96; p = 0.02) and a larger tumor size in linear regression analysis (p = 0.04). Conclusions Patients with ILA showed clinicoradiological features similar to those of idiopathic pulmonary fibrosis in elderly patients with early‐stage NSCLC. Identifying the clinical implications of ILA in early‐stage lung cancer will guide clinicians in providing appropriate management for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical implication of interstitial lung abnormality in elderly patients with early‐stage non‐small cell lung cancer

et al. 2022

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“…PFT results (spirometry, lung volume, DLCO) have been used to predict which patients have interstitial lung disease (ILD) [ 14 ]. Using new parameters such as PEF relative to FVC along with DACO (DLCO adjusted for lung volume) could improve screening for ILD [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Spirometry Reference Equations Including Existing and Novel Parameters

Johnson¹,

Johnson²

2022

TORMJ

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Introduction Spirometry is an essential component of pulmonary function testing with interpretation dependent upon comparing results to normal. Reference equations for mean and lower limit of normal (LLN) are available for usual parameters including forced vital capacity (FVC), forced expiratory volume in the first second of an FVC maneuver (FEV1), and FEV1/FVC. However, standard parameters do not fully characterize the flow-volume loop and equations are unavailable for upper limit of normal (ULN). The aim of this study was to develop reference equations for existing and novel spirometry parameters, which more fully describe the flow-volume loop, and to compare these to previously reported equations. Methods Data from healthy participants in NHANES III was used to derive reference equations for existing and novel spirometry parameters accounting for birth sex, ethnicity (Caucasian, Mexican American, Black) for ages 8 to 90 years. An iterative process determined %predicted LLN and ULN. Equations were compared to published reported equations. Results Reference equations were developed for mean, LLN and ULN for existing and novel spirometry parameters for ages 8 to 90. The derived equations closely match mean values of previously published equations, but more closely fit the LLN. Mexican-American and Caucasian values were similar (within 2%) so were combined, while Black relative to Caucasian/Mexican-American were lower for some parameters. Conclusion These reference equations which account for birth sex, age, height, and ethnicity for existing and novel spirometry parameters provide a more comprehensive and quantitative evaluation of spirometry and the flow-volume curve.

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“…Another way that could alert the specialist to the presence of an ILD could be a modified lung function test, namely the measurement of lung volumes, spirometry, and TLco test. The presence of a restrictive syndrome, i.e., decreased TLCO, could indicate the presence of an ILD, but although it has a high specificity, the sensitivity is low [44]. However, in these situations, if warranted, additional investigations should be recommended in order to confirm or exclude a potential interstitial lung disease.…”

Section: What Solutions Exist and How Can We Improve The Diagnostic P...mentioning

confidence: 99%

Speaking of the “Devil”: Diagnostic Errors in Interstitial Lung Diseases

Arcana,

Crișan-Dabija,

Caba

et al. 2023

JPM

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Interstitial lung diseases are respiratory diseases, which affect the normal lung parenchyma and can lead to significant pulmonary fibrosis, chronic respiratory failure, pulmonary hypertension, and ultimately death. Reuniting more than 200 entities, interstitial lung diseases pose a significant challenge to the clinician, as they represent rare diseases with vague and insidious respiratory symptoms. As such, there are many diagnostic errors that can appear along the journey of the patient with ILD, which leads to significant delays with implications for the prognosis and the quality of life of the patient.

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Derivation and Validation of a Diagnostic Prediction Tool for Interstitial Lung Disease

Cited by 12 publications

References 29 publications

Clinical implication of interstitial lung abnormality in elderly patients with early‐stage non‐small cell lung cancer

Clinical implication of interstitial lung abnormality in elderly patients with early‐stage non‐small cell lung cancer

Spirometry Reference Equations Including Existing and Novel Parameters

Speaking of the “Devil”: Diagnostic Errors in Interstitial Lung Diseases

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