Derivation of a Unique Body Surface Area (Bsa) Formula for Calculation of Relatively Safe Doses of Dog and Human Anticancer Drugs

Saganuwan, Saganuwan Alhaji

doi:10.4172/1948-5956.1000493

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Therefore, the therapeutic modality adopted in our study was in line with our previous experiments with mouse models (Maeda et al, 2017), in which the drug was administered 24 h prior to HIFU irradiation. The drug dose was based on the body surface area (BSA), which was calculated from body weight (BW) using a dose conversion table for dogs (Saganuwan, 2017).…”

Section: Methodsmentioning

confidence: 99%

Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Horise

Maeda²,

Konishi

et al. 2019

Front. Pharmacol.

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Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

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Section: Methodsmentioning

confidence: 99%

Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Horise

Maeda²,

Konishi

et al. 2019

Front. Pharmacol.

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“…Latent is the acquisition of neutral information with no immediate effects on behavior [29] as seen between a naive and experienced animal [7]. But dog's intelligence is of three components; instinctive intelligence, adaptive intelligence as well as working and obedience intelligence [22].Therefore the intelligence of dogs may be classi ed according to their functions as working (e.g.Doberman Pinscher,German Shepherd, Border Collie), hunting (Labrador Retriever, Golden Retriever), companion (Standard Poodle) and toying (Papilon) intelligence [23].But nutrition, genetics, environment, diseased condition inter alia, may affect EQ. However, study on evolution of encephalization quotient revealed that carnivore andother mammals showed abrupt increase in median log-encephalization quotients, indicating higher brain volume relative to body mass, at the end -Midcene, but gradual increases in the variance of log EQs.…”

Section: Discussionmentioning

confidence: 99%

“…The dogs classi ed according to Coren [22] as brightest are: Border Collie, Standard Poodle, German Shepherd, Golden Retriever, Doberman Pinscher, Shetland, Labrador Retriever, Papillion, Rottweiler and Australian Cattle Dog were used for the study. Their body weight, body surface area, height, k = 0.14 and β = 0.528 were considered as reported by Saganuwan [23].…”

Section: Methodsmentioning

confidence: 99%

Modified Formulas for Calculation of Encephalization Quotient in Dogs

Saganuwan

2021

Preprint

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ObjectiveDogs are a breed of animals that play important roles, ranging from security passing through companionship to models of research for application in humans. Intelligence is the key factor to success in life, most especially for dogs that are used for security purposes at the airports, seaports, public places, houses, schools and farms. However, it has been reported that there is correlation between intelligence, body weight, height and craniometry in human. In view of this, literatures on body weight, height and body surface areas of ten dogs were assessed with a view to determining their comparative level of intelligence.ResultsFindings revealed that dogs share brain common allometric relationships with human as shown by Encephalization Quotient (EQ)= Brain Mass/0.14 x Body weight0.528 as compared with Brain Mass /0.12 x Body Weight0.66 and Brain Mass (E)=kpβ, where p is the body weight,k=0.14 and β=0.528 which yielded better results as compared with the other formulas. Dogs with BSA, weight and height similar to that of human are the most intelligent. Doberman Pinscher is the most intelligent followed by German Shepherd, Labrador Retriever, Golden Retriever, respectively.

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“…The intelligence of dogs was classified according to Coren [22] in decreasing order as follows: Border collie, Standard Poodle, German shepherd, and Golden retriever, Doberman pinscher, Shetland, Labrador retriever, Papillion, Rottweiler and Australian Cattle Dog used in the present study. Their body weight, body surface area, height, k = 0.14 and β = 0.528 were applied as reported by Saganuwan [23]. Total brain volume and age of the dogs were calculated using the formulas TBV = 182.3 + 0.7 × Cranial Capacity and TBV = 396.5 X Age + 0.7 × CC respectively [24].…”

Section: Methodsmentioning

confidence: 99%

Modified formulas for calculation of encephalization: quotient in dogs

Saganuwan

2021

BMC Res Notes

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Objective Dogs are a breed of animals that play important roles in security service, companionship, hunting, guard, work and models of research for application in humans. Intelligence is the key factor to success in life, most especially for dogs that are used for security purposes at the airports, seaports, public places, houses, schools and farms. However, it has been reported that there is correlation between intelligence, body weight, height and craniometry in human. In view of this, literatures were searched on body weight, height and body surface areas of ten dogs with intent to determining their comparative level of intelligence using encephalization quotient. Results Findings revealed that dogs have relationship of brain allometry with human as proven by encephalization quotient $$\left( {{\text{EQ}}} \right)\, = \,{\text{Brain Mass}}/0.{14}\, \times \,{\text{Body weight}}^{{0.{528}}} ,{\text{ Brain Mass}}/0.{12}\, \times \,{\text{Body Weight}}^{{0.{66}}}$$ EQ = Brain Mass / 0.14 × Body weight 0.528 , Brain Mass / 0.12 × Body Weight 0.66 and Brain Mass (E) = kpβ, where p is the body weight; k = 0.14 and β = 0.528, respectively. Saganuwa’s formula yielded better results as compared with the other formulas. Dogs with body surface area (BSA), weight and height similar to that of human are the most intelligent. Doberman pinscher is the most intelligent followed by German shepherd, Labrador retriever, Golden retriever, respectively.

show abstract

Derivation of a Unique Body Surface Area (Bsa) Formula for Calculation of Relatively Safe Doses of Dog and Human Anticancer Drugs

Cited by 6 publications

References 22 publications

Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Modified Formulas for Calculation of Encephalization Quotient in Dogs

Modified formulas for calculation of encephalization: quotient in dogs

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