Derivation of composites of chitosan-nanoparticles from crustaceans source for nanomedicine: A mini review

Abere, Dare Victor; Ojo, Sammy A.; Paredes-Epinosa, Maria Belen; Hakami, Ali

doi:10.1016/j.bea.2022.100058

Cited by 21 publications

(9 citation statements)

References 54 publications

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“…Chitosan nanoparticles are formed by the interaction of positively charged chitosan with negatively charged molecules such as DNA, RNA, and drugs, via electrostatic interactions [ 1 , 59 , 84 , 85 , 86 , 87 ]. These nanoparticles can be administered to the body via various routes such as oral, topical, or injection [ 78 , 88 , 89 ].…”

Section: Chitosan-based Nanosystem Of Smart Drug Delivery Systemmentioning

confidence: 99%

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Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.

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Section: Chitosan-based Nanosystem Of Smart Drug Delivery Systemmentioning

confidence: 99%

“…Table 3 shows the ability of CS NPs to deliver various drug compounds and to increase their effectiveness. Positive NPs may cross the mitochondrial negative potential barrier, and lower mitochondrial membrane potential (MMP) by causing mitochondrial malfunction or death [ 84 ].…”

Section: Csnps and Mechanism Anticancer Actionmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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“…At higher pH values, the polymer is insoluble. This dependence of solubility on pH allows for the use of chitosan in various forms: solutions, suspensions, nanoparticles [ 17 ], bionanocomposites [ 18 ], gels [ 19 , 20 , 21 , 22 ], capsules [ 23 ], films, membranes [ 24 ], fibers [ 25 ], etc. The solubility of chitosan in slightly acidic aqueous solutions increases significantly with a decrease in molecular weight and an increase in the degree of deacetylation [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review

et al. 2023

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This review provides an analysis of experimental results on the study of alkaline heterogeneous deacetylation of chitin obtained by the authors and also published in the literature. A detailed analysis of the reaction kinetics was carried out considering the influence of numerous factors: reaction reversibility, crystallinity and porosity of chitin, changes in chitin morphology during washing, alkali concentration, diffusion of hydroxide ions, and hydration of reacting particles. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of “free” water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.

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“…The CHI derivatization is currently widely investigated to obtain customized physicochemical features [ 27 ]. Trimethylated chitosan [ 28 ] and thiolated chitosan [ 29 ] are among the more extensively utilized and favored mucoadhesive CHI derivatives.…”

Section: Introductionmentioning

confidence: 99%

Crosslinked Chitosan Nanoparticles with Muco-Adhesive Potential for Intranasal Delivery Applications

Gagliardi

Chiarugi

Cesari

et al. 2023

IJMS

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Intranasal drug delivery is convenient and provides a high bioavailability but requires the use of mucoadhesive nanocarriers. Chitosan is a well-established polymer for mucoadhesive applications but can suffer from poor cytocompatibility and stability upon administration. In this work, we present a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles. We used 2,6-pyridinedicarboxylic acid as a biocompatible crosslinker and compared the obtained particles with those prepared by ionotropic gelation using sodium tripolyphosphate. Nanoparticles were tested to evaluate the size and the surface charge, as well as their stability in storage conditions (4 °C), at the nasal cavity temperature (32 °C), and at the body temperature (37 °C). The crosslinked chitosan nanoparticles showed a size around 150 nm and a surface charge of 10.3 mV ± 0.9 mV, both compatible with the intranasal drug administration. Size and surface charge parameters did not significantly vary over time, indicating the good stability of these nanoparticles. We finally tested their cytocompatibility in vitro using SHSY5Y human neuroblastoma and RPMI 2650 human nasal epithelial cells, with positive results. In conclusion, the proposed synthetic system shows an interesting potential as a drug carrier for intranasal delivery.

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Derivation of composites of chitosan-nanoparticles from crustaceans source for nanomedicine: A mini review

Cited by 21 publications

References 54 publications

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review

Crosslinked Chitosan Nanoparticles with Muco-Adhesive Potential for Intranasal Delivery Applications

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