“…Many factors can affect the magnitude of permeability of fractured rock masses, including fracture length [28][29][30][31], aperture [32][33][34], surface roughness [35,36], dead-end [37], number of intersections [38,39], hydraulic gradient [40], boundary stress [41,42], anisotropy [43][44][45][46], scale [47][48][49][50], stiffness [51], coupled thermo-hydro-mechanical-chemical (HTMC) processes [52][53][54][55], and precipitation-dissolution and biogeochemistry [56]. The discrete fracture network (DFN) model, which can consider most of the above parameters, has been increasingly utilized to simulate fluid flow in the complex 2 Geofluids fractured rock masses [57][58][59][60], although it cannot model the aperture heterogeneity of each fracture [61][62][63]. In the numerical simulations and/or analytical analysis, the linear governing equation such as the cubic law is solved to simulate fluid flow in fractures by applying constant hydraulic gradients ( ) on the two opposing boundaries, such as = 1 [57,[64][65][66][67][68]], = 0.1 …”