Derivation of Nephrogenic Adenomas from Renal Tubular Cells in Kidney-Transplant Recipients

Mazal, Peter R.; Schaufler, Roland; Altenhuber-Müller, Romana; Haitel, Andrea; Watschinger, Bruno; Kratzik, Christian; Krupitza, Georg; Regele, Heinz; Meisl, F.; Zechner, O.; Kerjaschki, Dontscho; Susani, Martin

doi:10.1056/nejmoa013413

Cited by 146 publications

(124 citation statements)

References 41 publications

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“…[15][16][17] In the normal kidney, aquaporin-1 is only expressed in epithelial cells of proximal tubules and in the descending limb of Henle, but not in other nephron segments, collecting ducts or urothelial cells, whereas aquaporin-2 is selectively expressed in collecting ducts. 1,2 Only two studies of aquaporin-1 and aquaporin-2 in small series of renal cell carcinomas have been published in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Signal detection was performed with the avidin-biotin reaction, using peroxidase, except in cytokeratin 7 staining, where alkaline phosphatase was used. Antigen retrieval for cytokeratin 7 was performed by microwave pretreatment in citrate buffer (pH 6.0) for 10 min with 450 W, and for CD10 by autoclave pretreatment for 10 min with 450 W. For aquaporin-1, aquaporin-2, and PAX-2 this was done by microwave pretreatment for 20 min at 120 W, and 3 Â 5 min each at 450 W. 15 …”

Section: Immunohistochemistrymentioning

confidence: 99%

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Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study

et al. 2005

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Diagnostic use of antibodies against aquaporin water channel proteins and PAX-2, a nuclear transcription factor in renal development, was tested in 202 renal neoplasms, using tissue microarray technique. Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on 102 clear cell renal cell carcinomas, 44 papillary renal cell carcinomas (among them 34 type 1 and 10 type 2), 24 chromophobe renal cell carcinomas, three collecting duct carcinomas (carcinomas of the collecting ducts of Bellini), and 29 oncocytomas. Aquaporin-1 expression was found in clear cell renal cell carcinomas and papillary renal cell carcinomas of both types (78 and 73%, respectively), but not in chromophobe renal cell carcinomas, collecting duct carcinomas, and oncocytomas. Aquaporin-2 expression was not seen in any of the tested tumors. PAX-2 and CD10 was found in the majority of clear cell renal cell carcinomas (88 and 85%, respectively) but only in few papillary renal cell carcinomas, chromophobe renal cell carcinomas and oncocytomas. Decrease or loss of aquaporin-1 and PAX-2 was shown in higher grades compared to lower grades of clear cell renal cell carcinomas (Po0.0001 and o0.0245, respectively). Cytokeratin 7 was rarely seen in clear cell renal cell carcinomas, type 2 papillary renal cell carcinomas, and oncocytomas, but was found in the majority of type 1 papillary renal cell carcinomas (97.1%) and chromophobe renal cell carcinomas (88%). Aquaporin-1 and PAX-2 expression was found to correlate with nuclear grading for clear cell renal cell carcinomas but not for papillary renal cell carcinomas. No correlation of tumor stage and aquaporin-1 and PAX-2 expression was seen. Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading.

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Section: Discussionmentioning

confidence: 99%

Section: Immunohistochemistrymentioning

confidence: 99%

Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study

et al. 2005

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“…49 A recent study suggests that nephrogenic metaplasia (adenoma) is neither metaplastic nor neoplastic in nature. 50 Molecular studies in the setting of transplantation suggest that this lesion is truly nephrogenic in origin and results from the implantation of renal tubular cells at sites of prior urothelial injury with subsequent proliferation of epithelial elements.…”

Section: Nephrogenic Metaplasia (Adenoma)mentioning

confidence: 99%

Benign mimickers of prostatic adenocarcinoma

2004

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“…6 The significance of PAX2 in renal development has been confirmed both in experimental animal models and in patients with spontaneous PAX2 mutations. [7][8][9][10] In addition, PAX2 is detected in renal cell carcinomas, 11 Wilms' tumors, 12,13 and nephrogenic adenomas 14,15 and is proposed to be a specific marker in identification of lesions of renal origin.…”

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confidence: 99%

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

et al. 2007

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PAX2 is a urogenital developmental transcription factor expressed in the Wolffian ducts, developing kidneys, and Mü llerian ducts during embryonic stage. Its function in renal development is well documented and its clinical application in the diagnosis of lesions of renal origin has been reported recently. However, information on its role in the Mü llerian-derived genital tract is sparse. In this study, we investigated the expression of PAX2 in human female genital tract using immunohistochemistry. We demonstrated that PAX2 was expressed specifically in the epithelial cells of fallopian tube, endometrial and endocervical glands, but not in the stromal tissues in these areas. PAX2 was detected in secondary Mü llerian structures in the ovary, such as endometriotic and endosalpingiotic glands and rete ovarii, but not in ovarian surface epithelium, surface epithelium-derived inclusion cysts, stroma, or sex-cord-derived structures such as follicles, oocytes, and corpus luteum. In addition, PAX2 was detected in 67% of ovarian papillary serous carcinomas (N ¼ 36) but rarely in peritoneal malignant mesotheliomas, with two exceptions (N ¼ 54). Interestingly, the two PAX2-positive 'peritoneal malignant mesotheliomas' were from female patients and were positive for estrogen receptor. The significance of expression of PAX2 and estrogen receptor in these cases is under investigation. Taken together, we suggest that PAX2 is a novel Mü llerian-specific epithelial marker when used in proper clinical settings. Identification of PAX2 in the majority of papillary serous carcinomas of the ovary but not in the ovarian surface epithelium or epithelium-derived inclusion cysts suggests that this malignant epithelial tumor may be directly derived from the primary or secondary Mü llerian epithelium in or surrounding the ovary, rather than from the surface epithelium or its derivatives.

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Derivation of Nephrogenic Adenomas from Renal Tubular Cells in Kidney-Transplant Recipients

Abstract: Nephrogenic adenomas in renal-transplant recipients are derived from tubular cells of the renal transplants and are not metaplastic proliferations of the recipient's bladder urothelium.

Cited by 146 publications

References 41 publications

Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study

Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study

Benign mimickers of prostatic adenocarcinoma

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

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