Derivative spectroscopy and its applications in analysis

O’Haver, T. C.; Smith, Geoffrey; Gans, Paul; Sneddon, Joseph; Bezúr, László; Michel, Robert G.; Ottaway, J. M.; Miller, J. N.; Tauheed, A.; Fell, Anthony F.; Chadburn, B.P.; Cottrell, Christopher T.

doi:10.1039/ap9821900022

Cited by 87 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is used for the simultaneous determination of drugs in associations, as well. This technique allows to extract qualitative and quantitative information from spectra composed of analytes overlapping bands and interfering with the advantages of being simple, fast, inexpensive and accessible to most analytical quality control laboratories (O'Haver et al 1982;Rojas, Ojeda, 2009;Donato et al, 2010).…”

Section: Silc Active Pharmaceutical Ingredient Determination and Dosamentioning

confidence: 99%

Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets

Silva

Toledo

Vianna-Soares

2017

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by derivative ultraviolet spectrophotometry (DUS) in active pharmaceutical ingredient and/or dosage forms. The quantitation method of SILC active pharmaceutical ingredient by non-aqueous acid-base titration was developed using methanol as solvent and 0.1 mol/L of perchloric acid in acetic acid as titrant. The endpoint was potentiometrically detected. The non-aqueous titration method shows satisfactory repeatability and intermediate precision (RSD 0.70-1.09%). The neutralization reaction occurred in the stoichiometric ratio 1:1 in methanol. The determination of SILC active pharmaceutical ingredient or dosage forms by DUS was developed in the linear range from 10 to 40 µg/mL, in 0.01 mol/L HCl, using the first order zero-peak method at λ 256 nm. The DUS method shows selectivity toward tablets excipients, appropriate linearity (R 2 0.9996), trueness (recovery range 98.86-99.30%), repeatability and intermediate precision in three concentration levels (RSD 1.17-1.28%; 1.29-1.71%, respectively). Therefore, the methods developed are excellent alternatives to sophisticated instrumental methods and can be easily applied in any pharmaceutical laboratory routine due to simple and fast executions.Uniterms: Sildenafil citrate. Vasodilator. Derivative ultraviolet spectrophotometry. Non-aqueous acidbase titrimetry. Sildenafil citrate/quality control.

show abstract

Section: Silc Active Pharmaceutical Ingredient Determination and Dosamentioning

confidence: 99%

Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets

Silva

Toledo

Vianna-Soares

2017

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Algorithms based on least square fitting are commonly utilized to reduce random noise in the spectral data (Tsai and Philpot, 1998). Differentiation acts as a high-pass filter, the effects of which can be countered by a low-pass filter-smoothing step (O'Haver, 1982). It is important, however, to strike a good balance between smoothing for noise reduction and signal retention.…”

Section: First Second and Higher-order Derivative Images Derived Frmentioning

confidence: 99%

“…For instance, Malthus and Madeira (1993) found lower correlations between 2 nd derivative spectra and percent leaf surface area infected by a fungus, likely due at least in part to a decrease in signal detail in the 2 nd derivative spectra after smoothing. Smoothing can significantly decrease the effective spectral resolution and broaden peak widths; there is a trade-off between potential increases in SNR and peak-height attenuation as the level of smoothing increases (O'Haver, 1982). Also note that the low-altitude GER DAIS 3715 data was of relatively high radiometric resolution (15-bit) faclitating the generation of high quality higher-order derivative spectra.…”

Section: First Second and Higher-order Derivative Images Derived Frmentioning

confidence: 99%

2002 Hyperspectral Analysis of Hazardous Waste Sites on the Savannah River Site

Gladden¹

2003

View full text Add to dashboard Cite

“…In analytical chemistry and related sciences, because of the impact of environmental factors, the output signal is prone to drift and lead to an asymmetrical shape of peak, which will have effect on quantitative analysis. Ordinary derivative preprocessing technique [26,27] or wavelet transform [28] was usually used to eliminate the effect of baseline drift before quantitative analysis. Here, we use the NIOD to enhance the signal.…”

Section: Introduction On-integer Order Differentiation (Niod) Is a Gementioning

confidence: 99%

Haar Wavelet Based Implementation Method of the Non–integer Order Differentiation and its Application to Signal Enhancement

Pan

Meng

et al. 2015

Measurement Science Review

View full text Add to dashboard Cite

Non-integer order differentiation is changing application of traditional differentiation because it can achieve a continuous interpolation of the integer order differentiation. However, implementation of the non-integer order differentiation is much more complex than that of integer order differentiation. For this purpose, a Haar wavelet-based implementation method of non-integer order differentiation is proposed. The basic idea of the proposed method is to use the operational matrix to compute the noninteger order differentiation of a signal through expanding the signal by the Haar wavelets and constructing Haar wavelet operational matrix of the non-integer order differentiation. The effectiveness of the proposed method was verified by comparison of theoretical results and those obtained by another non-integer order differential filtering method. Finally, non-integer order differentiation was applied to enhance signal.

show abstract

Derivative spectroscopy and its applications in analysis

Cited by 87 publications

References 0 publications

Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets

Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets

2002 Hyperspectral Analysis of Hazardous Waste Sites on the Savannah River Site

Haar Wavelet Based Implementation Method of the Non–integer Order Differentiation and its Application to Signal Enhancement

Contact Info

Product

Resources

About