Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Suvorov, Nikita; Pogorilyy, Viktor; Diachkova, Ekaterina; Vasil'ev, Yuri; Миронов, А. Ф.; Grin, Mikhail A.

doi:10.3390/ijms22126392

Cited by 47 publications

(39 citation statements)

References 88 publications

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“…A clinical trial suggested oral curcumin together with visible light might be a new therapeutic method for moderate to severe plaque psoriasis [ 256 ]. Chlorophylls and derivatives as photosensitizers in PDT could be used to treat acne vulgaris and microbial infection [ 231 , 257 , 258 , 259 ]. In therapeutic PDT, the photosensitizers should absorb between 600 and 800 nm, and natural dyes might show potential as photosensitizers, which is worthy of further study.…”

Section: Resultsmentioning

confidence: 99%

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Wang

Zhou

et al. 2022

Molecules

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(1) Background: Dyes play an important role in food, medicine, textile, and other industries, which make human life more colorful. With the increasing demand for food safety, the development of natural dyes becomes more and more attractive. (2) Methods: The literature was searched using the electronic databases PubMed, Web of Science, and SciFinder and this scoping review was carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). (3) Results: 248 articles were included in this review. This review summarizes the research progress on natural dyes in the last ten years. According to structural features, natural dyes mainly include carotenoids, polyphenols, porphyrins, and alkaloids, and some of the newest dyes are summarized. Some pharmacological activities of carotenoids, anthocyanin, curcumin, and betalains in the last 10 years are summarized, and the biological effects of dyes regarding illumination conditions. The disadvantages of natural dyes, including sources, cost, stability, and poor bioavailability, limit their application. Here, some feasible strategies (potential resources, biotechnology, new extraction and separation strategies, strategies for improving stability) are described, which will contribute to the development and utilization of natural dyes. (4) Conclusion: Natural dyes show health benefits and potential in food additives. However, it is necessary for natural dyes to pass toxicity tests and quality tests and receive many regulatory approvals before their final entry into the market as food colorants or as drugs.

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Section: Resultsmentioning

confidence: 99%

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Wang

Zhou

et al. 2022

Molecules

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“…The ineffectiveness of PDT to Gram-negative bacteria is associated with the low permeability of their outer membrane for antibacterial agents. To improve the antimicrobial activity of photosensitizers, research groups are trying to synthesize their various derivatives, create conjugates, or use them in parallel with other compounds, e.g., antibiotics [13,43,44,[46][47][48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

2021

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Antibiotic therapy and photodynamic therapy (PDT) are commonly used to treat bacterial infections. Unfortunately, these methods are often ineffective. Therefore, agents that could effectively support antibiotic therapy and PDT in the inactivation of pathogens are being sought. Phytotherapy seems to be a good solution. The aim of the current research was to examine whether Polypodium vulgare extract (PvE) would improve the effectiveness of PDT and ciprofloxacin (CIP), an antibiotic that is commonly used to treat urinary tract infections in humans. UHPLC-MS analysis was performed to establish the PvE content. Chlorin e6 has been used as a photosensitizer in the PDT method. Biofilm production was established using the spectrophotometric method. The live cell count in planktonic and biofilm consortia was determined with the microdilution method and DAPI staining. The decrease of the bacterial survival, biofilm mass synthesis, and morphological changes of the bacteria under the combined treatments: PDT+PvE and CIP+PvE was noted. The results clearly indicate that the PvE can be used as a good agent for improving the efficacy of both PDT and the CIP activity to inactivate uropathogenic Escherichia coli strains. The obtained results are of particular value in the era of widespread and still-increasing drug resistance among bacterial pathogens.

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“…The application of APDT as a complementary step of partial removal of dental caries appears as a favorable therapeutic candidate to stimulate dental practitioners in adopting minimal intervention procedures instead of old-fashioned restorative methods [22]. A photosensitizer penetrates a target cell without causing any adverse effects itself, which is very helpful [23].…”

Section: Application Of Natural Photosensitizers In Dental Cariesmentioning

confidence: 99%

The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

et al. 2022

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Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, chlorella, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.

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Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Cited by 47 publications

References 88 publications

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections

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