Derivatization-free conventional and synchronous spectrofluorimetric estimation of atenolol and amlodipine

Abd El-Aziz, Heba; Zeid, Abdallah M.

doi:10.1016/j.saa.2023.123532

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

2024

DOI: 10.1016/j.saa.2023.123532

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Derivatization-free conventional and synchronous spectrofluorimetric estimation of atenolol and amlodipine

Heba Abd El-Aziz,

Abdallah M. Zeid

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2024

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Cited by 6 publications

References 55 publications

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Eco‐friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment

Ghozzy,

El‐Enany,

Tolba

et al. 2024

Luminescence

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A green, sensitive, and fast spectrofluorimetric technique for the simultaneous determination of atenolol (ATN) and losartan potassium (LSR) was developed. The proposed technique relied on the implementation of a first derivative synchronous fluorescence spectroscopy for the determination of the investigated drugs simultaneously without pretreatment procedures. The synchronous fluorescence of both drugs was measured in methanol at Δλ of 100 nm, and the first derivative peak amplitudes (1D) were measured at 321 nm for ATN and 348 nm for LSR, each at the zero‐crossing point of the other. The method was rectilinear over the concentration ranges of 100–1000 ng/mL and 50–500 ng/mL for ATN and LSR, respectively. The proposed technique was successfully applied for the determination of the studied drugs in their laboratory‐prepared mixture and pharmaceutical formulations, demonstrating high mean recoveries of 100.54% for ATN and 100.62% for LSR, without interference from common excipients. The results were in good agreement with those obtained by the comparison method. Three recent greenness assessment tools, the Eco‐Scale tool, the Green Analytical Procedure Index (GAPI) metric, and the Analytical GREEnness metric approach, were employed to affirm the greenness of the proposed method. The developed method was proven to be eco‐friendly.

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Eco‐friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment

Ghozzy,

El‐Enany,

Tolba

et al. 2024

Luminescence

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show abstract

Facile, eco‐friendly and sensitive fluorimetric approach for detection of chlorpromazine: Application in biological fluids and tablet formulations as well as greenness evaluation of the analytical method

Mostafa,

Mohamed,

Alahmadi

et al. 2024

Luminescence

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Monitoring antipsychotic drugs in biological fluids, such as human serum and urine, is important for ensuring the safety and efficacy of psychiatric treatments. This process helps maintain therapeutic drug levels, minimize side effects, and optimize patient well‐being. Chlorpromazine (CZ) is a widely prescribed antipsychotic drug used for conditions like schizophrenia, bipolar disorder, and acute psychosis. Almost all existing sensing techniques for CZ are either insensitive spectrophotometric methods or involve long and complex chromatographic procedures, limiting their routine use. In this work, we introduce a facile, green, and sensitive fluorimetric strategy with high reproducibility for detecting CZ in its pure form, tablet formulation, and spiked human plasma and urine without the need for derivatization reactions. The proposed method relies on the inhibition of the intramolecular photoinduced electron transfer (PET) effect by using 2.0 M acetic acid. This approach enables the linear detection of CZ from 3.0 to 600 ng/mL with remarkably low quantitation and detection limits of 1.51 and 0.49 ng/mL, respectively. Moreover, the developed method's greenness was evaluated.

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A Box-Behnken response surface methodology for optimizing fluorescent detection of cenobamate using graphene quantum dots: Environmental impact assessment and pharmacokinetic applications

Almalki,

Abduljabbar,

Alnemari

et al. 2024

Microchemical Journal

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Derivatization-free conventional and synchronous spectrofluorimetric estimation of atenolol and amlodipine

Cited by 6 publications

References 55 publications

Eco‐friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment

Eco‐friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment

Facile, eco‐friendly and sensitive fluorimetric approach for detection of chlorpromazine: Application in biological fluids and tablet formulations as well as greenness evaluation of the analytical method

A Box-Behnken response surface methodology for optimizing fluorescent detection of cenobamate using graphene quantum dots: Environmental impact assessment and pharmacokinetic applications

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