Derivatized Mesoporous Silicon with Dramatically Improved Stability in Simulated Human Blood Plasma

Canham, Leigh; Reeves, Christopher L.; Newey, J.; Houlton, M. R.; Cox, T. I.; Buriak, Jillian M.; Stewart, Michael

doi:10.1002/(sici)1521-4095(199912)11:18<1505::aid-adma1505>3.0.co;2-c

Cited by 173 publications

(59 citation statements)

References 9 publications

(14 reference statements)

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“…18 Any oxide present will then cause the PSi to degrade in aqueous solution. 14,19,20 With regard to stabilising PSi for drug delivery, Canham and co-workers 21 showed that using the hydrosilylation of dodecene to modify PSi the material showed little degradation over four weeks. Note however, that as dodecene renders the material hydrophobic, part of the reason for the excellent stability enhancement is that little or no water penetrates into the pore space.…”

Section: (L)mentioning

confidence: 99%

Mesoporous silicon photonic crystal microparticles: towards single-cell optical biosensors

et al. 2011

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In this paper we demonstrate the possibility of modifying porous silicon (PSi) particles with surface chemistry and recognition molecules (antibodies) such that these devices could potentially be used for singlecell identification or sensing. This is achieved by modifying PSi Rugate filters via hydrosilylation with surface chemistry that serves firstly, to protect the silicon surfaces from oxidation; secondly, renders the surfaces resistant to nonspecific adsorption of proteins and cells and thirdly, allows further functionality to be added such as the coupling of antibodies. The surface chemistry remained unchanged after sonication of the PSi to form PSi microparticles. The ability to monitor the spectroscopic properties of microparticles, and shifts in the optical signature due to changes in the refractive index of the material within the pore space, is demonstrated. The particles are shown to remain stable in physiological buffers and human blood for longer than one week. Finally, the modification of the PSi particles with functional antibodies is achieved.

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Section: (L)mentioning

confidence: 99%

Mesoporous silicon photonic crystal microparticles: towards single-cell optical biosensors

et al. 2011

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“…Functionalized porous silicon films were also placed into body fluids and their corrosion was showed to be reduced by two orders of magnitude compared to hydride-terminated samples. 8 Variations on this route include thermal instead of chemical catalysis of the hydrosilylation reaction. The reaction of an hydrogen-terminated porous silicon surface with desoxygeneted undecylenic acid at 95 C for 16 H under argon results in the formation of a (CH 2 ) 10 chain attached to the silicon surface via an Si-C bond on one end, and terminated with a carboxylic acid on the other end.…”

Section: Introductionmentioning

confidence: 99%

Functional nanostructured platforms for chemical and biological sensing

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2006

SPIE Proceedings

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The central goal of our work is to combine semiconductor nanotechnology and surface functionalization in order to build platforms for the selective detection of bio-organisms ranging in size from bacteria (micron range) down to viruses, as well as for the detection of chemical agents (nanometer range). We will show on three porous silicon platforms how pore geometry and pore wall chemistry can be combined and optimized to capture and detect specific targets. We developed a synthetic route allowing to directly anchor proteins on silicon surfaces and illustrated the relevance of this technique by immobilizing live enzymes onto electrochemically etched luminescent nano-porous silicon. The powerful association of the specific enzymes with the transducing matrix led to a selective hybrid platform for chemical sensing.We also used light-assisted electrochemistry to produce periodic arrays of through pores on pre-patterned silicon membranes with controlled diameters ranging from many microns down to tens of nanometers. We demonstrated the first covalently functionalized silicon membranes and illustrated their selective capture abilities with antibody-coated micro-beads. These engineered membranes are extremely versatile and could be adapted to specifically recognize the external fingerprints (size and coat composition) of target bio-organisms. Finally, we fabricated locally functionalized single nanopores using a combination of focused ion beam drilling and ion beam assisted oxide deposition. We showed how a silicon oxide ring can be grown around a single nanopore and how it can be functionalized with DNA probes to detect single viral-sized beads. The next step for this platform is the detection of whole viruses and bacteria.

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“…The most significant being the ease of controlled manufacture of pSi with different porosities, pore sizes and structures to meet a specific application[l2, 16,20]. This is achieved by varying the dopant type and amount, current, charge densities and the etching solutions components and concentrations.…”

Section: Introductionmentioning

confidence: 99%

Porous silicon microparticles as an alternative support for solid phase DNA synthesis

et al. 2005

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Derivatized Mesoporous Silicon with Dramatically Improved Stability in Simulated Human Blood Plasma

Cited by 173 publications

References 9 publications

Mesoporous silicon photonic crystal microparticles: towards single-cell optical biosensors

Mesoporous silicon photonic crystal microparticles: towards single-cell optical biosensors

Functional nanostructured platforms for chemical and biological sensing

Porous silicon microparticles as an alternative support for solid phase DNA synthesis

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