Deriving Cells Expressing Markers of Female Germ Cells from Premature Ovarian Failure Patient-Specific Induced Pluripotent Stem Cells

Wen, Yanfei; We, He; Jiang, Manbo; Zeng, Mingbing; Cai, Liuhong

doi:10.2217/rme-2016-0074

Cited by 7 publications

(1 citation statement)

References 46 publications

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“…Mouka et al generated iPSCs by transducing erythroblasts, which were derived from peripheral blood mononuclear cells purified from patients with azoospermia, with Sendai viruses expressing the four mentioned factors 7 . It has also been reported that specific iPSCs of patients with POF successfully expressed female germ cell markers 120 . The patient-specific iPSCs achieved the ability to differentiate into three germ layers with pluripotency, which provides a potential method for repairing spermatogenesis and oogenesis in patients with complex chromosomal rearrangements.…”

Section: Application Of Stem Cell Therapies In Infertilitymentioning

confidence: 92%

Stem Cell Therapies for Human Infertility: Advantages and Challenges

Xia

She

et al. 2022

Cell Transplant

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Physical and mental health and hormonal imbalance are associated with the problems related to infertility and reproductive disorders. The rate of infertility has increased globally over the years, due to various reasons. Given the psychosocial implications of infertility and its effects on the life of the affected people, there has been an increased focus on its treatment over the last several years. Assisted reproductive technology can only solve about 50% of the cases. Moreover, it contains significant risks and does not solve the fundamental problem of infertility. As pluripotent stem cells have the potential to differentiate into almost any type of cell, they have been widely regarded as a promising option in the development of stem cell-based fertility treatments, which could even correct genetic diseases in offspring. These advancements in reproductive biotechnology present both challenges and possibilities for solving infertility problems caused by various unexplainable factors. This review briefly presents the different types of infertility disorders and the potential applications of stem cells in the treatment of these reproductive diseases.

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Section: Application Of Stem Cell Therapies In Infertilitymentioning

confidence: 92%