Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Tupal, Ailar; Sabzichi, Mehdi; Ramezani, Fatemeh; Kouhsoltani, Maryam; Hamishehkar, Hamed

doi:10.1080/02652048.2016.1200150

Cited by 75 publications

(32 citation statements)

References 37 publications

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“…Tupal et al investigated antimelanoma potential of topical doxorubicin SLNs by cytotoxicity study on murine melanoma (B16F10) cells wherein SLNs presented superior cytotoxicity compared to doxorubicin solution.…”

Section: Particulate Drug Delivery Systemsmentioning

confidence: 99%

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

Ravikumar

Tatke

2019

J of Cosmetic Dermatology

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Background The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy‐resistant malignancies. Conventional topical products are beset with limitations, leading to lower efficacy. There is a growing need to develop topical formulations encapsulated in polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and liposomes exhibiting enhanced skin penetration and longer skin retention leading to better efficacy. Objective The objective of this article is the screening of reported novel drug encapsulated delivery systems effective topically in melanoma chemoprevention. Aim The scope of this work is to provide an overview pertaining to the development and evaluation of three exemplary drug delivery systems (DDS), namely vesicular, particulate, and specialized emulsions. Methods Topical drug delivery approaches targeting skin cancer have been reviewed and discussed. The focal point of the article is presentation of insights from published studies. Results This review focuses on the novel delivery systems in chemoprevention of melanoma with discussion highlighting on advances in topical delivery. Conclusion Literature indicates that drug‐loaded encapsulated topical formulations when compared with conventional dosage forms for skin cancer treatment exhibit greater efficacy and provide benefits like extended drug release, protection of the active ingredient against degradation, and lower skin irritation. Incorporation of phytoconstituents in newer delivery systems will be the way forward for improved topical chemoprevention strategy in melanoma. This has raised hope in making dermal therapy more useful and acceptable.

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Section: Particulate Drug Delivery Systemsmentioning

confidence: 99%

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

Ravikumar

Tatke

2019

J of Cosmetic Dermatology

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“…Heat is provided using a thermostatic hot plate with a magnetic stirrer. The receptor fluid is stirred by Teflon coated magnetic bead which is placed in the diffusion cell [5]. During each sampling interval, samples are withdrawn and replaced by equal volumes of fresh receptor fluid on each sampling.…”

Section: Spreadabilitymentioning

confidence: 99%

“…After incubation, media was replaced with 200 µl of DMSO to dissolve Formazan crystals. The 96 well plate was analyze using microplate reader by taking absorbance at 570 nm [5].…”

Section: Stability Studiesmentioning

confidence: 99%

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Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Majumdar

Dubey

2019

Int J App Pharm

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Objective: The aim of the present study is to develop docetaxel-loaded nano liquid crystals (NLCs) to enhanced and effective delivery of the drug to the skin cancer. Methods: NLCs bearing docetaxel were prepared by an emulsification solvent diffusion method. The formulated NLCs were characterized for average particle size, polydispersity index (PDI) Zeta potential, entrapment efficiency and in vitro drug release study. The prepared formulations were studied for it's in vitro cell line and cell uptake study. Results: It was revealed that the average size of NLCs was found 178.3±5.07, PDI was 0.189, percent entrapment efficiency was found 71.3±2.49 and Zeta potential was found-17.3±2.4. In vitro release determined by Franz diffusion cell was found 61.6±3.2% after 72 hr. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay shows that Docetaxel loaded NLCs were giving more cytotoxicity as compared to the plain drug. The cell uptake study was found enhanced uptake of fluorescein isothiocyanate (FITC) loaded NLCs in comparison to plain FITC. Docetaxel and docetaxel-loaded NLCs showed 28.3±0.3 and 39.3±1.3 growth inhibition respectively after 48h upon incubation at 0.5 µg/ml concentration (p<0.05). Conclusion: The result of the studies was concluded that NLCs can be used as impending drug delivery system which may enhance the drug uptake and maintain the drug level for longer period of time and it is potential carrier system which can be used for the treatment of skin diseases like cancer.

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“…In addition, stealth SLNs with particle size ≤200 mm are infrequently subject to blood clearance by the reticuloendothelial system in the liver and spleen [12]. SLNs are flexible nanocarriers and are used for drug delivery in nearly all routes of administration, including ocular [13], parenteral [14], oral [15], and topical [16]. SLNs can be formulated to sustain the drug release profile and therefore decrease the necessity for the repeated administration and enhance the therapeutic value of the treatment [17].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Papain Loaded Solid Lipid Nanoparticles Against Human Colorectal Adenocarcinoma Cell Line

Chandran¹,

Nachimuthu²

2018

Asian J Pharm Clin Res

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Objective: Colorectal cancer is one of the most commonly diagnosed cancer and also most common gastrointestinal malignancy with high prevalence rate in the younger population. Usually, cancer cells are surrounded by a fibrin coat which is resistant to fibrinolytic degradation. This fibrin coat is act as self-protective against natural killing mechanism. The main objective was to prepare papain-loaded solid lipid nanoparticles (P-SLN) by melt dispersion-ultrasonication method and investigated the cytotoxic efficacy against colorectal adenocarcinoma (human colorectal adenocarcinoma [HCT 15]) cells.Methods: Optimized polymer ratio was characterized by differential scanning calorimetry, Fourier-transform infrared, X-ray diffraction, scanning electron microscopy, entrapment efficiency, particle size and zeta potential analysis, in vitro drug release, and in vitro cytotoxicity studies on HCT-15 colorectal adenocarcinoma cells.Results: The results showed that the particle size, morphological character and zeta potential value of optimized batch P-SLN were 265 nm, spherical and −26.5 Mv, respectively. The in vitro drug profile of P-SLN exhibited that it produced sustain drug release, and the cell viability of HCT-15 against P-SLN shown better efficacy than pure papain enzyme.Conclusion: P-SLNs were successfully prepared and investigated the in vitro drug release and in vitro cell viability against HCT-15 cell line.

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Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer

Abstract: Our findings may open the possibilities for the topical delivery of Dox to the skin cancerous tissues.

Cited by 75 publications

References 37 publications

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview

Dermal Delivery of Docetaxel Loaded Nano Liquid Crystals for the Treatment of Skin Cancer

Formulation and Characterization of Papain Loaded Solid Lipid Nanoparticles Against Human Colorectal Adenocarcinoma Cell Line

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