Dermal Drug Delivery for Cutaneous Malignancies: Literature at a Glance

Gupta, Vandana; Trivedi, Piyush

doi:10.1007/s12247-015-9236-3

Cited by 5 publications

(3 citation statements)

References 390 publications

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“…Hydrophilic molecules diffuse mostly “laterally” through surfaces with less inter-lamellar spaces filled with water or across certain volumes. Polar molecules can also use the available spaces at the same end between the outer membrane and the corneocyte of the lamella ( Gupta and Trivedi, 2016 ).…”

Section: Routes Of Drug Penetration Via Skinmentioning

confidence: 99%

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Yang

et al. 2021

Front. Bioeng. Biotechnol.

230

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The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.

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Section: Routes Of Drug Penetration Via Skinmentioning

confidence: 99%

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Yang

et al. 2021

Front. Bioeng. Biotechnol.

230

View full text Add to dashboard Cite

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“…To limit the systemic (transdermal) delivery of drugs and allow for high deposition of drugs in the skin, it can be postulated that the higher the molecular weight and log P values of drugs the higher their possibility of depositing in skin layers. Listed below are the only FDA approved drugs for topical treatment of skin cancer: Other non-FDA approved therapies are also present in literature [15]- [17]; diclofenac, topical retinoids, resiquimod, piroxicam, mechlorethamine HCl, carmustine, potent glucocorticoids, betulinic acid, calcium besylate, and potassium dobesilate containing formulations.…”

Section: B Topical Therapiesmentioning

confidence: 99%

Skin cancer therapy: From conventional to nutraceutical based nanovesicular carriers

Bayoumi

Arafa

Nasr

et al. 2020

Archives of Pharmaceutical Sciences Ain Shams University

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“…The main advantage of these systems is that the in vivo fate of the drug is no longer mainly determined by the drug characteristics, but only by the carrier system, which favors a targeted and controlled drug release [14,15]. Moreover, nanotechnology is of interest for skin administration as it can be used to modify the drug permeation/penetration ensuring a direct contact with the stratum corneum [16][17][18]. Specialized literature has reported the use of nanotechnology in reducing the toxicity of 5-FU at therapeutic doses and in improving the 5-FU absorption from the skin surface.…”

Section: Introductionmentioning

confidence: 99%

Formulations Based on Drug Loaded Aptamer-Conjugated Liposomes as a Viable Strategy for the Topical Treatment of Basal Cell Carcinoma—In Vitro Tests

et al. 2021

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Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma. The 5-fluorouracil penetrability efficiency through the Strat-M membrane and the skin irritation potential of the obtained topical liposomal formulations were evaluated in vitro and the Korsmeyer Peppas equation was considered as the most appropriate to model the drug release. Additionally, the efficiency of cytostatic activity for targeted antitumor therapy and the hemolytic capacity were performed in vitro. The obtained results showed that the optimal liposomal formulation is a crosslinked gel based on sodium alginate and hyaluronic acid containing AS1411-aptamer conjugated liposomes loaded with 5-fluorouracil, which appeared to have favorable biosafety effects and may be used as a new therapeutic approach for the topical treatment of basal cell carcinoma.

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Dermal Drug Delivery for Cutaneous Malignancies: Literature at a Glance

Cited by 5 publications

References 390 publications

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Skin cancer therapy: From conventional to nutraceutical based nanovesicular carriers

Formulations Based on Drug Loaded Aptamer-Conjugated Liposomes as a Viable Strategy for the Topical Treatment of Basal Cell Carcinoma—In Vitro Tests

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