Dermal eosinophils in atopic dermatitis undergo cytolytic degeneration

Cheng, Janet F.; Ott, Nancy L.; Peterson, Ellen A.; George, Terry J.; Hukee, Margaret J.; Gleich, Gerald J.; Leiferman, Kristin M.

doi:10.1016/s0091-6749(97)70031-9

Cited by 103 publications

(80 citation statements)

References 45 publications

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“…28,29 To ascertain the ultrastructural characteristics of eosinophil cytolysis in vivo, tissue-infiltrated eosinophils were evaluated using TEM (Figure 1). Eosinophils within biopsies from the sinus and the skin (from patients with allergic sinusitis and hypereosinophilic syndrome, respectively) showed similar characteristics of cytolytic degranulation with disrupted PMs and nuclear envelope membranes.…”

Section: Resultsmentioning

confidence: 99%

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

Ueki

Melo

Ghiran

et al. 2013

Blood

272

345

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Section: Resultsmentioning

confidence: 99%

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

Ueki

Melo

Ghiran

et al. 2013

Blood

272

345

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“…In the present study, we show that eosinophils undergo cytolytic degranulation, releasing proteinladen eosinophilic granules into the surrounding tissue. Previous experimental and clinical investigations have demonstrated eosinophil cytolysis in gastric ulcer formations and human eosinophilic inflammatory disorders including IBD and atopic dermatitis, suggesting a link between eosinophil degranulation and the development of intestinal pathology (30,31,48).…”

Section: Discussionmentioning

confidence: 95%

Immunopathogenesis of Experimental Ulcerative Colitis Is Mediated by Eosinophil Peroxidase

Forbes

Murase

Yang

et al. 2004

The Journal of Immunology

149

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The precise role that individual inflammatory cells and mediators play in the development of gastrointestinal (GI) dysfunction and extraintestinal clinical manifestations of ulcerative colitis (UC) is unknown. In this study, we have used a mouse model of UC to establish a central role for eotaxin and, in turn, eosinophils in the development of the immunopathogenesis of this disease. In this model the administration of dextran sodium sulfate (DSS) induces a prominent colonic eosinophilic inflammation and GI dysfunction (diarrhea with blood and shortening of the colon) that resembles UC in patients. GI dysfunction was associated with evidence of eosinophilic cytolytic degranulation and the release of eosinophil peroxidase (EPO) into the colon lumen. By using IL-5 or eotaxin-deficient mice, we show an important role for eotaxin in eosinophil recruitment into the colon during experimental UC. Furthermore, using EPO-deficient mice and an EPO inhibitor resorcinol we demonstrate that eosinophil-derived peroxidase is critical in the development of GI dysfunction in experimental UC. These findings provide direct evidence of a central role for eosinophils and EPO in GI dysfunction and potentially the immunopathogenesis of UC.

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“…Affected skin lesions in AD reveal a mononuclear cell infiltrate, predominantly in the dermis, consisting of macrophages and activated memory CD4 + T cells bearing HLA-DR + and CD45RO + (2). The presence of eosinophilderived major basic protein and eosinophil cationic protein in the dermis, along with eosinophil degeneration, are indicative of eosinophil involvement in AD (3,4).…”

Section: Introductionmentioning

confidence: 99%

Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis

Spergel

Mizoguchi²,

Oettgen³

et al. 1999

J. Clin. Invest.

364

277

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Skin lesions in atopic dermatitis (AD) are characterized by hypertrophy of the dermis and epidermis, infiltration by T cells and eosinophils, and expression of the cytokines IL-4, IL-5, and IFN-γ. The role of these cytokines in the pathogenesis of AD is not known. We took advantage of a recently described murine model of AD elicited by epicutaneous sensitization with ovalbumin (OVA) (1) and of the availability of mice with targeted deletions of the IL-4, IL-5, and IFN-γ cytokine genes to assess the role of these cytokines in this model.OVA-sensitized skin from IL-5 -/-mice had no detectable eosinophils and exhibited decreased epidermal and dermal thickening. Sensitized skin from IL-4 -/-mice displayed normal thickening of the skin layers but had a drastic reduction in eosinophils and a significant increase in infiltrating T cells. These findings were associated with a reduction in eotaxin mRNA and an increase in mRNA for the T-cell chemokines macrophage inflammatory protein-2 (MIP-2), MIP-1β, and RANTES. Sensitized skin from IFN-γ -/-mice was characterized by reduced dermal thickening.These results suggest that both the T H 2 cytokines IL-4 and IL-5 and the T H 1 cytokine IFN-γ play important roles in the inflammation and hypertrophy of the skin in AD.

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Dermal eosinophils in atopic dermatitis undergo cytolytic degeneration

Cited by 103 publications

References 45 publications

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

Immunopathogenesis of Experimental Ulcerative Colitis Is Mediated by Eosinophil Peroxidase

Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis

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