2016
DOI: 10.1111/jdv.13977
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Dermal fillers: pathophysiology, prevention and treatment of complications

Abstract: Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long-lasting complications have been observed. This article discusses the key complications including pigmentary changes, hypersensitivity reactions, infections, nodule formation, granulomatous reactions, vascular occlusion and migration o… Show more

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Cited by 142 publications
(170 citation statements)
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“…A higher risk of complications is seen when large volumes of LIS or PMMA are injected in a single session or when industrial‐grade or adulterated low‐viscosity silicone is used . Bacterial biofilm around fillers might also play a role in the pathogenesis of such granulomatous reactions . The immune pathomechanism of GFBR to soft tissue fillers is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…A higher risk of complications is seen when large volumes of LIS or PMMA are injected in a single session or when industrial‐grade or adulterated low‐viscosity silicone is used . Bacterial biofilm around fillers might also play a role in the pathogenesis of such granulomatous reactions . The immune pathomechanism of GFBR to soft tissue fillers is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Early detection and management of vascular occlusion can help preserve the ischemic tissues. Emergency management of vascular compromise includes vigorous massage, topical nitroglycerin paste, warm compression, oral anticoagulants, and hyaluronidase injection . Hyaluronidase injection into the ischemic tissues has been widely accepted to be used to prevent skin necrosis from vascular compromise after HA injection.…”
Section: Introductionmentioning
confidence: 99%
“…We discussed the pathology results with the patient, who reported having received filler injection of HA in her midface years previously. While many complications of soft tissue augmentation appear immediately or occur shortly afterwards and are easily linked to the procedure, the occurrence of delayed filler migration poses a diagnostic challenge. There are several recent case reports of delayed filler migration presenting as discrete facial masses or periorbital oedema .…”
Section: Discussionmentioning
confidence: 99%