1986
DOI: 10.1002/jps.2600751114
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Dermal Penetration Enhancement Profile of Hexamethylenelauramide and Its Homologues: In Vitro Versus In Vivo Behavior of Enhancers in the Penetration of Hydrocortisone

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Cited by 32 publications
(7 citation statements)
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“…Percent diffusion reported (mean ( SD) was 67 ( 6 for hexamethylene lauramide, 67 ( 7 for the piperidine analog, 83 ( 11 for the pyrrolidinone analog, and 64 ( 6 for Azone. 18 Taken together this indicates that enhancer length as well as overall lipophilicity would be necessary descriptors for predicting enhancer activity.…”
Section: Resultsmentioning
confidence: 96%
See 1 more Smart Citation
“…Percent diffusion reported (mean ( SD) was 67 ( 6 for hexamethylene lauramide, 67 ( 7 for the piperidine analog, 83 ( 11 for the pyrrolidinone analog, and 64 ( 6 for Azone. 18 Taken together this indicates that enhancer length as well as overall lipophilicity would be necessary descriptors for predicting enhancer activity.…”
Section: Resultsmentioning
confidence: 96%
“…Azone has been the most widely studied chemical penetration enhancer of the 1980s although a considerable number of analogues with improved activity have been described. [12][13][14][15][16][17][18] Several studies suggest that Azone acts by solubilizing or increasing the entropy of highly ordered stratum corneum lipids. 19 Skin conductance experiments suggest that Azone also increases skin water content.…”
mentioning
confidence: 99%
“…Mirejovsky has patented a series of amides, where nitrogen is the part of a cycle [149]. In Table 17, relative activities of selected compounds with the same acyl chain length compared to Azone are listed.…”
Section: Cyclic Amidesmentioning
confidence: 99%
“…By the removal of a carbonyl group in lactam, cyclic amides 25 – 27 (Fig. ), analogues of compounds 9 , were obtained. 1‐(Azepan‐1‐yl)dodecan‐1‐one ( 26 ) showed an enhancing activity comparable to Azone ( 6 ) on the penetration of metronidazole through the isolated SC, and a better effect was shown by hydrocortisone at the penetration through the hairless mouse skin in vitro.…”
Section: Azone‐like Enhancersmentioning
confidence: 97%