Dermal targeting of<i>Centella asiatica</i>extract using hyaluronic acid surface modified niosomes

Wichayapreechar, Panikchar; Anuchapreeda, Songyot; Phongpradist, Rungsinee; Rungseevijitprapa, Wandee; Ampasavate, Chadarat

doi:10.1080/08982104.2019.1614952

Cited by 30 publications

(15 citation statements)

References 41 publications

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“…13 In addition, various forms of HA-based drug delivery systems including transfersomes, niosomes, hydrogels and microneedle patches have also been developed to enhance drug permeation through and into the intact skin or inflamed skin for topical disease treatment. [14][15][16][17] Curcumin (CUR) is a polyphenolic compound isolated from the turmeric plant. CUR has various pharmacological activities, such as analgesic, anti-inflammatory, anti-viral, anti-tumor and anti-oxidant.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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Background The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. Methods In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized by amide reaction technique to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. CUR-M was successfully prepared by dialysis, and the formulation was evaluated for particle size, zeta potential, surface morphology, entrapment effciency (EE%), drug loading (DL), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and the in vitro drug release. Additionally, in vitro skin permeation and retention, in vivo topical analgesic and anti-inflammatory activity, and skin irritation were assessed. Results The mean drug loading (DL), drug entrapment efficiency (EE), hydrodynamic diameter and zeta potential of CUR-M were 8.26%, 90.86%, 165.64 nm and −26.85 mV, respectively. CUR-M was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), it was found that there was an interaction between CUR and OHA, and CUR existed in CUR-M in an amorphous form. CUR-M exhibited sustained release in 48 h and good stability at 4 °C for 21days. CUR-M could significantly increase the skin penetration and retention of CUR and had better analgesic and anti-inflammatory activities in vivo when compared with CUR solution. Hematoxylin-eosin staining results revealed that the transdermal penetration mechanism of CUR-M might be related to the hydration of stratum corneum by HA. In addition, CUR-M showed no skin irritation to mouse skin. Conclusion CUR-M might be a promising and safe drug delivery system for the treatment of topical diseases.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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“…A combination of isoflavone mixtures might exhibit more efficacies than single compound due to a eutectic behavior of isoflavone extract leading to improved mobility, solubility, and permeation of such phytoestrogens through the skin [44,45]. Capability for The ovariectomized rats were chosen as an alternative model to mimic skin ageing in post-menopausal women due to their short life time span and adequate time to obtain signs of pre-mature aging following the ovary removal.…”

Section: Discussionmentioning

confidence: 99%

“…A combination of isoflavone mixtures might exhibit more efficacies than single compound due to a eutectic behavior of isoflavone extract leading to improved mobility, solubility, and permeation of such phytoestrogens through the skin [ 44 , 45 ]. Capability for improving the biophysical skin properties of FSE was in a particle size-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Biophysical Skin Parameters of Topically Applied Fermented Soybean Extract-Loaded Niosomes with No Systemic Toxicity in Ovariectomized Rats

2021

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Despite the known beneficial impacts of estrogen used as hormone replacement therapy to ameliorate signs of skin aging in postmenopausal women, its compliance rates are low. A significant amount of estrogen may be absorbed into the blood circulation and can lead to systemic actions. Soy isoflavone exhibits biological activities similar to synthetic estrogen because it is a heterocyclic phenolic compound. The disadvantage of most topical ingredients based on isoflavone is that they contain biologically inactive glycoside forms, which must be converted to a readily absorbed aglycone for the topical application. The purposes of this study were to develop niosomes-loaded Aspergillus oryzae-fermented soybean extract (FSE) to enhance skin absorption with proven systemic side effect compared to estrogen application. Skin hydration and viscoelasticity of 75 days post-ovariectomized (OVX) Wistar rats following 84-day topical treatment with various tested gel formulations containing fermented soybean extract (FSE) were evaluated. The tested formulations were gel + FSE nanoniosomes, gel + FSE microniosomes, gel + FSE (200 µg FSE/9 cm2/rat), gel + blank nanoniosomes (a negative control), and gel + 17β-estradiol (E2) nanoniosomes (a positive control, 20 µg E2/9 cm2/rat). Changes in vaginal cornifications and weights of uteri, livers, and kidneys in the OVX rats and signs of primary skin irritation in the rabbits were evaluated for their toxicities. Results showed that FSE-loaded nanoniosomes improved the skin hydration and viscoelasticity better than gel + FSE microniosomes and gel + FSE, respectively, but lower than those of gel + E2 nanoniosomes (p < 0.05). Unlike all gel + E2 nanoniosomes, the FSE formulations showed no changes in vaginal cells and weights of uteri, livers, and kidneys and no signs of skin irritation. In conclusion, The FSE niosome-based gels should be promising candidates for delivering phytoestrogens against signs of skin aging with no systemic toxicities.

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“…To improve skin absorption profiles of pentacyclic triterpenes (AS, AA, or MA), principal pharmacologically active compounds of CA, several carrier systems such as liposomes, transfersomes, nanostructured lipid carriers, or niosome have been implemented. [16][17][18][19] These pharmaceutical approaches could improve the penetration into skin layers with increased therapeutic efficacy such as increased dermal thickness in animal models. Nevertheless, the content of CA in these formulations was restrained, ranging from 0.1% to 1.0% (w/v) due to its low solubility and/or limited loading in the vesicles.…”

Section: Formulation Development and Selection Of Suspending Agent Of Ca Nsmentioning

confidence: 99%

“…16 Different pharmaceutical approaches such as employment of penetration enhancers, lipid nanoparticles, micelles, liposomal, and niosomal vesicle systems have been implemented to enhance the solubility of the waterinsoluble ingredients and to promote skin absorption into relevant skin layers. [16][17][18][19] These approaches have been effective in increasing the skin absorption of the active ingredients of CA, with improved pharmacological activities. 16,17 However, even with these solubilization systems, the content of CA in external formulations has been restrained below 1.0% w/v, because of the low solubility of AA or MA in formulations.…”

Section: Introductionmentioning

confidence: 99%

High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation

Kim¹,

Park²,

Kim³

et al. 2021

IJN

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Dermal targeting ofCentella asiaticaextract using hyaluronic acid surface modified niosomes

Cited by 30 publications

References 41 publications

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Improvement of Biophysical Skin Parameters of Topically Applied Fermented Soybean Extract-Loaded Niosomes with No Systemic Toxicity in Ovariectomized Rats

High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation

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