Dermatitis herpetiformis associated with ulcerative colitis

Lambert, D.; Collet, E.; Foucher, J.L.; Escallier, F.; Dalac, S.

doi:10.1111/j.1365-2230.1991.tb01236.x

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…Sulfasalazine is a readily available and well‐tolerated medication, effective in the long‐term management of inflammatory bowel disease and rheumatoid arthritis. There have been three previous reports of its successful use in DH 1–3 . These cases indicate that sulfasalazine might be as effective as the sulphone, dapsone, in controlling this condition in some individuals.…”

Section: Discussionmentioning

confidence: 99%

Sulfasalazine and dermatitis herpetiformis

et al. 2005

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Dermatitis herpetiformis that is unable to be controlled using dapsone and a gluten-free diet presents a therapeutic challenge. Three cases that responded well to sulfasalazine are presented. Two cases, who were unable to tolerate dapsone, had a rapid response to sulfasalazine, without apparent side-effects. The third case with dapsone-responsive blistering dermatoses, presumed to be dermatitis herpetiformis on the basis of serology, showed an excellent clinical response to sulfasalazine, but after 6 weeks of therapy had to cease it because of side-effects. Sulfasalazine is metabolized variably to sulfapyridine, a sulphonamide known to be an effective therapy for dermatitis herpetiformis but no longer available. Sulfasalazine should be considered as a management option for dermatitis herpetiformis.

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Section: Discussionmentioning

confidence: 99%

Sulfasalazine and dermatitis herpetiformis

et al. 2005

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“…To date, there have been eight reported cases of ulcerative colitis associated with dermatitis herpetiformis (Table 1) (7,12,(23)(24)(25)(26)(27). Davies et al (12) reported 2 such cases of 42 patients, and Yasui et al (7) reported 1 such case of 49 Japanese patients with dermatitis herpetiformis.…”

Section: Discussionmentioning

confidence: 99%

“…Davies et al (12) reported 2 such cases of 42 patients, and Yasui et al (7) reported 1 such case of 49 Japanese patients with dermatitis herpetiformis. Ulcerative colitis preceded dermatitis herpetiformis in the seven cases for which the temporal sequence was described (7,12,23,(25)(26)(27). As for the pattern of IgA deposits, three were granular (1 2, 26,27), the Japanese case was linear (7), and data were not available for the remaining four cases (12,23,24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Ulcerative colitis preceded dermatitis herpetiformis in the seven cases for which the temporal sequence was described (7,12,23,(25)(26)(27). As for the pattern of IgA deposits, three were granular (1 2, 26,27), the Japanese case was linear (7), and data were not available for the remaining four cases (12,23,24,25). Six cases showed villous atrophy (7,12,23,24,26,27) and two showed normal jejunal mucosa (12,25).…”

Section: Discussionmentioning

confidence: 99%

“…As for the pattern of IgA deposits, three were granular (1 2, 26,27), the Japanese case was linear (7), and data were not available for the remaining four cases (12,23,24,25). Six cases showed villous atrophy (7,12,23,24,26,27) and two showed normal jejunal mucosa (12,25). Other associated conditions include polyarthritis, Raynaud's phenomenon (1 2), and hepatitis (24).…”

Section: Discussionmentioning

confidence: 99%

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A Japanese case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis

et al. 1996

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: A number of extraintestinal complications of ulcerative colitis have been described. However, only a few cases of ulcerative colitis associated with dermatitis herpetiformis have been documented. We report a case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis in a Japanese woman. The patient first developed exanthema on the extremities at the age of 18 years. Subsequently, her skin disease was diagnosed as dermatitis herpetiformis with linear IgA deposits at the dermoepidermal junction. A biopsy specimen from the jejunum did not show villous atrophy. Subsequently, she was diagnosed with primary sclerosing cholangitis at age 34 years, and with ulcerative colitis 2 years later. The patient died of hepatic failure at age 40 years. Bile duct cancer was found at autopsy. Both dermatitis herpetiformis and primary sclerosing cholangitis are diseases of the immune system that are associated with HLA-B8 and -DR3 in whites. Our patient had neither of these serotypes. The immune mechanisms involved in the extraintestinal complications of inflammatory bowel disease are briefly discussed.

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Dermatitis herpetiformis in a patient with ulcerative colitis

Pipili¹,

Ioannidou²

2008

Inflammatory Bowel Diseases

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Dermatitis herpetiformis associated with ulcerative colitis

Cited by 17 publications

References 10 publications

Sulfasalazine and dermatitis herpetiformis

Sulfasalazine and dermatitis herpetiformis

A Japanese case of ulcerative colitis associated with dermatitis herpetiformis and primary sclerosing cholangitis

Dermatitis herpetiformis in a patient with ulcerative colitis

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