Dermatitis herpetiformis in China: a report of 22 cases

Zhang, F.; Yang, Baoqi; Lin, Yan; Chen, S.; Zhou, Guangjun; Wang, G.; Chen, X.; Zhang, Y.; Tian, Haijun; Yu, Man; Shi, Zhonghua; Zhang, Defei

doi:10.1111/j.1468-3083.2011.04204.x

Cited by 28 publications

(45 citation statements)

References 33 publications

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“…Additionally, it is accepted that all DH patients have CD in theory, due to sharing a common mechanism, even though they usually have subclinical gastrointestinal disease and only mild symptoms. In our DH patients, 37.5% were diagnosed with CD by histopathological examination, whereas this was reported as 3.3%-18% in the literature (13,22).…”

Section: Discussioncontrasting

confidence: 40%

“…In spite of reports that cardiovascular diseases were generally associated with BP, cardiovascular diseases were also associated with other ABDs in some case reports (13,22,24). Nevertheless, Marzano at al.…”

Section: Discussionmentioning

confidence: 92%

“…In patients with DH it was reported that gluten in particular and less often milk and iodine in the diet, ultraviolet B rays, and repetitive minor trauma on extensor skin surfaces possibly had an exacerbating effect (10,13,22). In 22 DH patients reported by Zhang et al, the lesions had progressed after delivery in one of them (4.5%) and after intervertebral disc surgery in another (22). In our study, we found that emotional stress was the most probable triggering cause.…”

Section: Discussionmentioning

confidence: 99%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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“…In another study of 22 patients with dermatitis herpetiformis, the authors searched for IgA antibodies against endomysial antigen (EmA) and tTG and only found these antibodies in 50% and 62.5% of their sera, respectively. Small intestinal biopsies confirmed the presence of celiac disease in only two patients [5]. Pruritus is the predominant DH symptom; the eruption is symmetric, with a predilection for the shoulders, buttocks, elbows, and thighs and extensor areas [1].…”

Section: Introductionmentioning

confidence: 99%

“…In brief, we used sodium dodecyl sulfate (SDS) extracts of human and bovine epidermis fractionated by 7% SDS polyacrylamide gel electrophoresis (SDS-PAGE) according to the Laemmli method [9,10,14]. Gels were transferred onto nitrocellulose membranes (5,10). As experimental controls, we utilized 1) an anti-desmoplakin multiepitope cocktail from Progen (Heidelberg, Germany), 2) the serum of a patient with bullous pemphigoid that recognized bullous pemphigoid antigens 1 and 2 (230 and 180 kDa, respectively), and 3) serum from a patient with paraneoplastic pemphigus.…”

Section: Immunoblotting (Ib)mentioning

confidence: 99%

Untitled

2012

Our Dermatol Online

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Introduction: The precise nature of the previously described dermatitis herpetiformis bodies remains unknown. Aims: Our study was conducted to investigate the nature of dermatitis herpetiformis bodies in the skin in 7 cases of dermatitis herpetiformis, and to search for the presence of autoantibodies in other organs. Methods: We utilized clinical, histopathologic, and immunologic methods to evaluate these patients. Results: Dermatitis herpetiformis bodies were found to be comprised of an amalgamation of immunoglobulins A and M, as well as molecules reactive with antibodies to armadillo repeat gene deleted in velo-cardio-facial syndrome, desmoplakins 1 and 2, and plakophilin 4. In addition, we found immunologic colocalization with selected autoantibodies associated with mitochondria in the skin, heart, kidney, and peripheral nerves. The dermatitis herpetiformis bodies did not demonstrate immunologic colocalization with tissue/epidermal transglutaminase. Conclusions:The complete biochemical nature of dermatitis herpetiformis bodies requires further characterization. Dermatitis herpetiformis bodies in these patients appear to be distinctly different than cytoid bodies. Further studies are required to determine if the antibodies to noncutaneous organs are pathogenic, and/or contribute to systemic morbility in dermatitis herpetiformis patients.

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Dapsone and Autoimmune Bullous Disorders

Ortega‐Loayza

Werth

2015

Blistering Diseases

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Dermatitis herpetiformis in China: a report of 22 cases

Cited by 28 publications

References 33 publications

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

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Dapsone and Autoimmune Bullous Disorders

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