Dermatitis herpetiformis is associated with atrophic but not with goitrous variant of Hashimoto's thyroiditis

Zettinig, Georg; Weissel, M; Flores, Juana A.; Dudczak, Robert; Vogelsang, Harald

doi:10.1046/j.1365-2362.2000.00590.x

Cited by 38 publications

(19 citation statements)

References 20 publications

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“…Previous studies have shown that patients with DH similar to those with celiac disease frequently have associated autoimmune conditions such as thyroid diseases and insulin-dependent diabetes mellitus [9, 22, 23]. In the present study two DH patients with CAG had thyroid disease, one of them also pernicious anemia and one patient vitiligo.…”

Section: Discussionsupporting

confidence: 54%

Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study

Alakoski

Salmi

Hervonen

et al. 2012

Clinical and Developmental Immunology

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Background and Objective. Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia. Methods. Specimens were drawn from the gastric corpus and antrum and examined for atrophy, intestinal metaplasia, and Helicobacter pylori. Duodenal biopsies were taken. Results. Atrophic corpus gastritis was more frequent in DH than in controls (16.0% and 2.7%, resp., P < 0.001); atrophy in the antrum was rare in both groups (3.2% and 1.1%, P = 0.34). Intestinal metaplasia was present in 13 (14.0%) DH and 12 (6.5%) control patients (P = 0.038) and H. pylori in 17 (18.3%) and 17 (9.3%) (P = 0.028), respectively. Small-bowel villous atrophy was seen in 76% of the DH patients, equally in patients with and without chronic gastritis. One DH patient with atrophic gastritis developed gastric cancer. Conclusion. In DH, chronic atrophic gastritis was common in the corpus, but not in the antrum. H. pylori will partly explain this, but corpus atrophy is suggestive of an autoimmune etiology. Atrophic gastritis may increase the risk of gastric cancer. We advocate performing upper endoscopy with sufficient histologic samples in DH.

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Section: Discussionsupporting

confidence: 54%

Chronic Gastritis in Dermatitis Herpetiformis: A Controlled Study

Alakoski

Salmi

Hervonen

et al. 2012

Clinical and Developmental Immunology

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“…There is an increased prevalence of thyroid disease and presence of thyroid microsomal antibodies in patients with DH. [69][70][71] Hypothyroidism is more common than hyperthyroidism. 70 Increased age and thyroid microsomal antibodies are associated with a higher risk of thyroid disease.…”

Section: Associated Disorders Key Pointsmentioning

confidence: 99%

Dermatitis herpetiformis

Bolotin

Petronic‐Rosic

2011

Journal of the American Academy of Dermatology

144

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“…Although our study does not demonstrate evidence of thyrocyte damage with antiTGase II IgA binding, it suggests the possibility that TGase II IgA deposition may predict impending thyroid dysfunction as has been shown for jejunal mucosa by Maki and coworkers (22). Additional evidence of thyroid antibody involvement comes from studies that show that patients with celiac disease are more prone to developing atrophic thyroiditis because a hypoechoic pattern is common in thyroid antibody-positive subjects with celiac disease (47,48). A role for celiac disease as a factor in the development of autoimmune thyroid disease, induced via anti-TGase II mechanisms, is supported by the observation that patients with autoimmune thyroid disease and celiac disease show improvement of thyroid disease on a strict gluten-free diet (44,49).…”

Section: Thyroid Autoimmunity In Celiac Diseasementioning

confidence: 44%