Dermatofibrosarcoma Protuberans

Luu, Carrie; Messina, Jane L.; Brohl, Andrew S.; Sondak, Vernon K.

doi:10.1002/9781119196235.ch70

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Dermatofibrosarcoma protuberans (DFSP), an uncommon tumor, is characterized by a high possibility of local invasion and recurrence. Appropriate primary resection is important because DFSP is a locally destructive tumor with a high recurrence rate if it is not completely excised 1 . However, the recurrence of conventional surgery is initially 50% to 60% because of conservative excision margins 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta‐analysis

Chen

Jiang

2021

Dermatologic Therapy

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Dermatofibrosarcoma protuberans (DFSP) is a tumor with low-grade malignancy and high recurrence rates. Wide local excision (WLE) is essential for DFSP, but its surgical excision margin is controversial. This study aimed to examine whether resection margin is associated with the prognosis of patients with DFSP by systematically reviewing related literature. Studies that evaluated the relationship between excision margins and outcomes after WLE were retrieved from the Cochrane Library, PubMed, Embase, and Web of Science databases. Relative risk (RR) estimates and 95% confidence intervals (CIs) were measured via a random-effect model to evaluate the subsequent outcomes: recurrence rate, mortality, and positive surgical margin rate. Sensitivity and subgroup analyses were simultaneously carried out. The metaanalysis of eight observational literatures demonstrated a significant positive correlation of ≥3 cm margin with the recurrence rate (RR = 0.17, 95% CI 0.09-0.31) and the positive surgical margin rate (RR = 0.09, 95% CI 0.02-0.46). The same result was observed in the recurrence rate in all subgroups. The stability of the above outcomes was authenticated via sensitivity analyses. Our meta-analysis illustrated that excision with <3 cm surgical margin exhibited an increased risk of poor DFSP prognosis (high recurrence rate and increasing positive margin rate).

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Section: Introductionmentioning

confidence: 99%

Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta‐analysis

Chen

Jiang

2021

Dermatologic Therapy

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Dermatofibrosarcoma Protuberans on the Occipital Scalp Showed Uncommon Presentation: A Case Report

Jeong,

Chung,

Cho

2024

Korean J Head Neck Oncol

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Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma, with an incidence of about 0.8% to 5% per million people per year, accounting for 1% of soft tissue sarcomas. In its early stage, DFSP is typically found as a violet or pinkish macule or patch, and it can develop into a palpable mass with ulceration or bleeding. The standard treatment for DFSP is wide local excision of the tumor with a 2- to 3-cm negative margin, and radiation therapy or chemotherapy can be conducted with surgical treatment. A 35-year-old man had a palpable mass on the left side of his occipital scalp without color change, ulceration, or bleeding, which typically are present in malignancy. A magnetic resonance imaging (MRI) scan showed a 3-cm homogenous enhanced mass without adhesion between the scalp and the mass. Unexpectedly, a biopsy revealed the round mass to be DFSP. A wide excision and rotation of the scalp flap were performed. The patient recovered without any complications and received adjuvant radiotherapy at a dose of 60 Gray (Gy) for six weeks. There was no recurrence through six months of follow-up. Here we report this unique case of DFSP with atypical presentation.

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Dermatofibrosarcoma Protuberans

Cited by 2 publications

References 67 publications

Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta‐analysis

Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta‐analysis

Dermatofibrosarcoma Protuberans on the Occipital Scalp Showed Uncommon Presentation: A Case Report

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