Dermatofibrosarcoma protuberans：clinical and pathological analysis of Asian samples from one center experience.

Abstract

Background：Dermatofibrosarcoma protuberans（DFSP）is one of rare and low-grade fibrohistiocytic tumor with malignant potential biological behavior. With the pathological character of the finger-like lesion invading soft tissues, DFSP is considered to be high rate of local recurrence. Method: In this study, we reported a retrospective study of 17 DFSP patients with surgery medical history and long-time follow-up period. All the cases were reviewed by research group with the clinical features, operation outcomes and pathological parameters. Results: 17 Asian patients were included in this study (the mean age is 41.82 years old with 9 females and 8 males). Location of DFSP are the belly (7/17 41.2%), the chest（2/17 11.8%）,the shoulder(5/17 29.4%), the face(1/17 5.9%), the perineum（1/17 5.9%） and the right leg（1/17 5.9%）. 6 cases were closed by plastic surgical suture（35.29%），3 cases by full thickness skin graft（17.65%）and 8 cases by pedicled flap（47.06%）. CD34 and Vimentin positively is 100%, 90% respectively. Desmin and S-100 negatively were 100%. The median value of Ki-67 is 12%. Conclusion: The challenge of DFSP is clinical local control after operation. The first choice of DFSP treatment is surgery with the aim of clear margin and properly reconstruction. For the clinical practice, Enhancing the clinical recognition of DFSP in the initial medical visit is important for proper management and operation opportunity.