Dermatofibrosarcoma protuberans of the breast: A case report

Pohlodek, Kamil; Mečiarová, Iveta; Grossmann, P.; Kinkor, Z

doi:10.3892/ol.2017.6206

Cited by 17 publications

(22 citation statements)

References 28 publications

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“…These mammography findings are not specific and hence, breast DFSP can mimic a benign breast lesion such as fibroadenoma, sebaceous cyst or an abscess. 1 , 4 , 5 , 9 , 15 In the current case, the mammography findings were consistent with findings reported in the literature with a skin-based well-defined lesion with no microcalcification nor architectural distortion, mimicking a sebaceous cyst.…”

Section: Discussionsupporting

confidence: 91%

“…Another useful ultrasonographic finding that can help to distinguish DFSP is the presence of a peripheral hyperechoic rim in the subcutaneous tissue that represents a mixture of tumour cells and fibrous tissue infiltrating the subcutaneous fat. 1,2,4,5,9,11 On magnetic resonance imaging (MRI), DSFP has no specific features and appears as a well-defined nodule or mass that is T1 isointense to the muscle and shows homogenous or heterogenous enhancement on post-contrast examination. However, owing to its high spatial resolution and high tissue characterisation, MRI is very helpful in delineation of tumour extent and evaluating the anatomical relation of the tumour to adjacent structures.…”

Section: Discussionmentioning

confidence: 99%

“…3 However, DFSP very rarely involves the breast, mimicking primary breast tumour. 1,2,4,5 Awareness of this rare entity and its typical imaging features is crucial to avoid the misdiagnosis of DFSP with a benign breast lesion and to suggest a preoperative diagnosis. However, reports of imaging features have been scarce in the literature compared to histopathological features, with few reported cases of the left breast, which was mobile and non-tender, measuring 3 × 3 cm.…”

Section: Case Reportmentioning

confidence: 99%

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Dermatofibrosarcoma Protuberans Mimicking Primary Breast Neoplasm: A case report and literature review

Al-Farsi

Al-Brashdi

Al-Salhi

et al. 2020

Sultan Qaboos Univ Med J

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Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing mesenchymal neoplasm of the dermis and subcutaneous tissues that has a low- to intermediate-grade malignancy. DFSP commonly involves the trunk and extremities, and very rarely the breast skin, mimicking a primary breast neoplasm with few reported cases in the literature. We report a 35-year old female patient who was referred to the Royal Hospital, Muscat, Oman in 2017, with a two-year history of a slow growing left breast lump. Assessment of the breasts with mammography revealed a lobulated lesion in the left-upper-inner quadrant with neither microcalcification nor architectural distortion, mimicking a benign lesion. However, on ultrasound, the lesion had suspicious features with increased vascularity and hence, it was categorised as breast imaging reporting and data system (BIRAD) IV. The patient underwent left breast wide local excision and the histopathological diagnosis was dermatofibrosarcoma protuberans.Keywords: Breast; Dermatofibrosarcoma Protuberans; Ultrasonography; Oman.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Dermatofibrosarcoma Protuberans Mimicking Primary Breast Neoplasm: A case report and literature review

Al-Farsi

Al-Brashdi

Al-Salhi

et al. 2020

Sultan Qaboos Univ Med J

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“…When difficult to diagnose, FISH analysis of the COL1A1-PDGF β fusion gene using routine biopsy specimens is a quick and convenient method [ 37 ]. In reported 5 cases of breast DFSP with gene detection, 4 cases presented the COL1A1-PDGF β fusion gene [ 9 , 23 , 38 , 39 ], another presented the PDGF β gene rearrangement [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Wang

Chen

et al. 2020

BioMed Research International

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Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade fibroblastic mesenchymal tumor derived from the dermis. The aim of this retrospective analysis was to summarize the clinicopathological data from our cases and published cases to offer more evidence for the recognition of dermatofibrosarcoma protuberans (DFSP). A total of 6 breast DFSP patients who had received treatment in our hospital were retrospectively enrolled, and detailed clinicopathological data were gathered for analysis. The median age was 29.5 years (ranging from 17 to 42 years). Most cases presented a red or brown-red, mobile, well-circumscribed, protruding, breast mass (ranging from 1 to 3 cm). For histopathology, all cases (6/6) showed a storiform pattern of spindle cells that were positive for CD34 (6/6) and Vimentin (5/6) and negative for smooth muscle actin (0/6) and S-100 protein (0/6). The majority of patients (5/6) underwent wide local excision, with 2 cases treated with radiotherapy. With a median follow-up of 36 months, all 6 patients survived without recurrence or metastasis. The PubMed database was used to search for similar cases. Eventually, 36 cases were included in this review, while cases without detailed clinical information or not reported in English were excluded from the analysis. To summarize, DFSP of the breast is an extremely rare malignancy characterized by spindle tumor cells arranged in a storiform pattern and positivity for CD34. The core needle biopsy is one of the crucial methods for its preoperative diagnosis. Management of DFSP is mainly based on surgical excision. It is prone to local recurrence, so long-term follow-up is required.

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“…Dermatofibrosarcoma can affect all the parts of the body, but its preferred seats are the trunk 50 to 60%, the limbs 20 to 30%, the head 15 to 20% [6,7]. Its mammary location is very rare [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Darier and Ferrand Dermatofibrosarcoma with Mammary Location: About a Case

Biaye¹,

Diallo²,

Mbodji³

et al. 2018

Gynecol Reprod Health

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Introduction: Dermatofibrosarcoma is a sarcoma of intermediate degree of malignancy with strong local aggressiveness with a low but real metastatic potential. Its breast location is very rare. Observation: It was a 40-year-old woman who has never been pregnant who was followed for a retro-areolar tumor of the ulcerated left breast that had been evolving for more than eight weeks. A mammary cytopract was done which was in favor of a phyllode tumor. We performed a large surgical excision on the patient and the histology of the operative specimen was in favor of a dermatofibrosarcoma of Darier and Ferrand with healthy resection margins. Discussion: The mammary location of Darier and Ferrand syndrome is rare. With early diagnosis an infectious and hemorrhagic complication can be avoided whereas, wide excision improves the prognosis.

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Dermatofibrosarcoma protuberans of the breast: A case report

Cited by 17 publications

References 28 publications

Dermatofibrosarcoma Protuberans Mimicking Primary Breast Neoplasm: A case report and literature review

Dermatofibrosarcoma Protuberans Mimicking Primary Breast Neoplasm: A case report and literature review

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Darier and Ferrand Dermatofibrosarcoma with Mammary Location: About a Case

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