Dermatofibrosarcoma protuberans of the vulva: clinico‐ pathological, immunohistochemical and flow cytometric study of a case

Alvarez-Canas, M. Concepcion; Mayorga, Marta; Fernández, Fidel Fernández; Val-Bernal, J. Fernando; Moral, Eloy; León, Carlos; Erasun, F.; Lerma, Diego

doi:10.3109/00016349609033292

Cited by 16 publications

(12 citation statements)

References 17 publications

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“…Achieving these margins on the vulva may be difficult, especially if the tumor is near the clitoris. As such, several authors have described wide margins (but <3 cm depending on vulvar location), with reexcision as indicated in those areas where margins are positive [3, 5, 12]. In our two cases, the original resection margins were microscopically positive for infiltrating tumor cells beyond the encapsulated tumor.…”

Section: Discussionsupporting

confidence: 75%

“…In our two cases, the original resection margins were microscopically positive for infiltrating tumor cells beyond the encapsulated tumor. This finding was described in four other cases of DFSP of the vulva [5, 7, 12]. Our patients required more than one excision to achieve clear margins, after which both have remained disease‐free.…”

Section: Discussionmentioning

confidence: 99%

“…Of the eight published cases that describe immunohistochemistry, one case was positive for nonspecific esterase [3], one for factor VIII–related antigen [4], two for vimentin (the current cases), one for muscle actin (our first case), and two others for CD34 [10, 11]. Other cases were negative for muscle actin [7, 12], s100 [7, 12], desmin [7], XIIIa [10, 11], HHF35 [10], and E9 [10]. Immunohistochemistry of DFSP has been largely unrewarding, except for CD34, which is positive in most cases of DFSP [14].…”

Section: Discussionmentioning

confidence: 99%

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Dermatofibrosarcoma Protuberans of the Vulva: Report of Two New Cases and Review of the Literature

Zlatnik

Dinh

Lucci

et al. 1999

J Low Genital Tract Dis

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dermatofibrosarcoma Protuberans of the Vulva: Report of Two New Cases and Review of the Literature

Zlatnik

Dinh

Lucci

et al. 1999

J Low Genital Tract Dis

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“…There have been several reports dealing with nuclear DNA content of DFSP. 19,20,22,25–35 In these reports, aneuploidy was found in only one out of 23 cases of DFSP, while five out of 19 cases (26.3%) showed aneuploidy in the present study. All aneuploid peaks of DFSP found in the present study were single and near‐diploidy.…”

Section: Discussioncontrasting

confidence: 48%

Dermatofibrosarcoma protuberans: An analysis of proliferative activity, DNA flow cytometry and p53 overexpression with emphasis on its progression

Sasaki

Ishida

Horiuchi

et al. 1999

Pathology International

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The aim of this study is to evaluate the degree and spectrum of malignancy of dermatofibrosarcoma protuberans (DFSP) in the aspect of proliferative activity, flow cytometric DNA analysis, and p53 immunoreactivity. Twenty-three tumors from 19 cases of DFSP including three cases of DFSP with fibrosarcomatous areas (DFSP-FS) were studied in comparison with its allied fibrohistiocytic tumors; that is, dermatofibroma (DF; 46 cases), fibrosarcoma (FS; four cases), and malignant fibrous histiocytoma (MFH; 11 cases). MIB-1 labeling index (LI) of DFSP was significantly higher than that of DF and was lower than those of FS and of MFH. In ordinary DFSP, the recurrent tumors exhibited significantly higher MIB-1 LI than that of the primary tumors, whereas the primary tumors showed almost the same proliferative activity of DF. DFSP-FS tended to have a higher proliferative activity than DFSP without FS-area (ordinary DFSP). In five of 19 cases of DFSP, aneuploidy (near-diploidy) was found in four recurrent and one primary tumors. Immunohistochemical p53 overexpression was found in three of 19 cases of DFSP which also showed higher proliferative activity and aneuploidy. All cases of DF were immunohistochemically negative for p53, but most of the cases of FS and MFH were positive. Although DFSP has been classified in a category of fibrohistiocytic tumor of intermediate malignancy, the recurrent DFSP, DFSP-FS, and DFSP with aneuploidy and/or p53 overexpression could be a subgroup of DFSP with more aggressive clinical behavior than ordinary primary ones.

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“…Primary vulvar dermatofibrosarcoma protuberans (DFSP) is a rare malignancy, with only 14 cases reported in the medical literature [1–11]. We present a case of vulvar DFSP in the youngest and the first pregnant patient.…”

mentioning

confidence: 97%

Dermatofibrosarcoma Protuberans of the Vulva: A Rare Tumor Presenting During Pregnancy in a Teenager

Schwartz

Kuo

Goldberg

1999

J Low Genital Tract Dis

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Dermatofibrosarcoma protuberans of the vulva: clinico‐ pathological, immunohistochemical and flow cytometric study of a case

Cited by 16 publications

References 17 publications

Dermatofibrosarcoma Protuberans of the Vulva: Report of Two New Cases and Review of the Literature

Dermatofibrosarcoma Protuberans of the Vulva: Report of Two New Cases and Review of the Literature

Dermatofibrosarcoma protuberans: An analysis of proliferative activity, DNA flow cytometry and p53 overexpression with emphasis on its progression

Dermatofibrosarcoma Protuberans of the Vulva: A Rare Tumor Presenting During Pregnancy in a Teenager

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