Dermatofibrosarcoma Protuberans on Adult Toes: A Case Report and Review of the Literature

Madden, Caitlin; Spector, Adam; Siddiqui, Sarwat; Mirkin, Gene; Yim, Joon; Hao, Xingpei

doi:10.21873/anticanres.13323

Cited by 16 publications

(14 citation statements)

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“…Nonetheless, it is worth noting that CD34 may be reduced or absent in areas of fibrosarcomatous transformation [ 23 , 33 , 35 ]. Fibrosarcoma is a high-grade soft sarcoma with increased cellular fibroblastic proliferation in the herringbone pattern with atypia and mitoses [ 36 ]. DFSP is often positive for Vimentin and negative for other routinely tested markers, including S100, SMA, CK, EMA, Desmin, CD68, and XIIIa.…”

Section: Discussionmentioning

confidence: 99%

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Wang

Chen

et al. 2020

BioMed Research International

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Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade fibroblastic mesenchymal tumor derived from the dermis. The aim of this retrospective analysis was to summarize the clinicopathological data from our cases and published cases to offer more evidence for the recognition of dermatofibrosarcoma protuberans (DFSP). A total of 6 breast DFSP patients who had received treatment in our hospital were retrospectively enrolled, and detailed clinicopathological data were gathered for analysis. The median age was 29.5 years (ranging from 17 to 42 years). Most cases presented a red or brown-red, mobile, well-circumscribed, protruding, breast mass (ranging from 1 to 3 cm). For histopathology, all cases (6/6) showed a storiform pattern of spindle cells that were positive for CD34 (6/6) and Vimentin (5/6) and negative for smooth muscle actin (0/6) and S-100 protein (0/6). The majority of patients (5/6) underwent wide local excision, with 2 cases treated with radiotherapy. With a median follow-up of 36 months, all 6 patients survived without recurrence or metastasis. The PubMed database was used to search for similar cases. Eventually, 36 cases were included in this review, while cases without detailed clinical information or not reported in English were excluded from the analysis. To summarize, DFSP of the breast is an extremely rare malignancy characterized by spindle tumor cells arranged in a storiform pattern and positivity for CD34. The core needle biopsy is one of the crucial methods for its preoperative diagnosis. Management of DFSP is mainly based on surgical excision. It is prone to local recurrence, so long-term follow-up is required.

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Section: Discussionmentioning

confidence: 99%

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Wang

Chen

et al. 2020

BioMed Research International

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“…An American study conducted between 2000 and 2010 found an incidence of 41 cases in 10 million patients. 3 Some studies observed a higher incidence in women and black people. It mostly affects the trunk (40%–50%), the proximal limbs (30%–40%), and the head and cervical region (10%–15%).…”

Section: Discussionmentioning

confidence: 99%

“…It mostly affects the trunk (40%–50%), the proximal limbs (30%–40%), and the head and cervical region (10%–15%). 3 …”

Section: Discussionmentioning

confidence: 99%

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Tumor in the plantar region: dermatofibrosarcoma protuberans in an infrequent topography

Perazzoli

Bonamigo

Heck

et al. 2020

Anais Brasileiros de Dermatologia

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Dermatofibrosarcoma protuberans is a rare mesenchymal tumor; it is locally aggressive and presents high rates of local recurrence. It may present as a nodular or plaque vegetating lesion. It mainly affects the trunk and proximal limbs, being rare in the distal extremities. Biopsy and immunohistochemistry help confirm the diagnosis. The authors report a case of dermatofibrosarcoma protuberans with plantar region involvement, a rare presentation. To the best of the authors’ knowledge, only 11 cases of involvement of the feet were described in the international literature.

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“…Debulking surgery prolongs long-term survival and controls local recurrence. Currently, radical surgery is considered the preferred treatment for localized fibrosarcomas[13].…”

Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma metastases to the pancreas: A case report

Cai

Fang

Cao

et al. 2019

WJCC

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BACKGROUNDIn general, malignant tumors metastasize to the pancreas in < 1% of cases. Most patients miss the opportunity for further surgery due to distant metastases; however, for fibrosarcomas, aggressive surgery may be helpful even if distant metastases occur. Hence, we report such a case and share some valuable information about the disease.CASE SUMMARYA 45-year-old man was admitted with recurrent epigastric pain for 10 days. The abdominal pain was mainly related to bloating with nausea, but no other associated symptoms. No particular signs were found on abdominal examination or laboratory testing. In 2003, a local distal expanded resection of the primary fibrosarcoma in the left chest wall was performed. Then, a left pneumonectomy was performed in 2017 due to diffuse metastases from the fibrosarcoma to the left lung. Enhanced computed tomography (CT) and magnetic resonance imaging of the upper abdomen suggested multiple masses of different sizes involving the head and tail of the pancreas; no local lymph node enlargement was noted. The postoperative pathologic diagnosis revealed a fibrosarcoma of the pancreas. A CT re-examination 6 mo postoperatively showed no local recurrence or distant metastases.CONCLUSIONA fibrosarcoma is a rare low-grade malignant tumor, and metastases to the pancreas are even rarer. Patients with a history of a fibrosarcoma should consider the possibility of metastasis when a pancreatic neoplasm is demonstrated. Surgical resection is the preferred treatment.

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Dermatofibrosarcoma Protuberans on Adult Toes: A Case Report and Review of the Literature

Cited by 16 publications

References 0 publications

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Tumor in the plantar region: dermatofibrosarcoma protuberans in an infrequent topography

Dermatofibrosarcoma metastases to the pancreas: A case report

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