Dermatofibrosarcoma Protuberans on the Chest with a Variety of Clinical Features Masquerading as a Keloid: Is the Disease Really Protuberant?

Kimura, Kumiko; Inadomi, Toru; Yamauchi, Wataru; Yoshida, Yukihiro; Kashimura, Tsutomu; Terada, Tadashi

doi:10.5021/ad.2014.26.5.643

Cited by 11 publications

(10 citation statements)

References 5 publications

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“…Owing to their similar clinical presentation, keloids have been misdiagnosed as other benign and malignant skin tumors and vice versa (25). Of these, dermatofibrosarcoma protuberans is the most commonly linked to keloids amongst others such as keloidal dermatofibroma (26), keloidal basal cell carcinoma, keloidal atypical fibroxanthoma (27), suggesting a possible overlap between them (28).…”

Section: Keloids: Scars or Cancerous Tumors?mentioning

confidence: 99%

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

2019

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Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids display many cancer-like characteristics such as progressive uncontrolled growth, lack of spontaneous regression and extremely high rates of recurrence. Phenotypically, keloids are consistent with non-malignant dermal tumors that are due to the excessive overproduction of collagen which never metastasize. Within the remit of keloid pathobiology, there is increasing evidence for the various interplay of neoplastic-promoting and suppressing factors, which may explain its aggressive clinical behavior. Amongst the most compelling parallels between keloids and cancer are their shared cellular bioenergetics, epigenetic methylation profiles and epithelial-to-mesenchymal transition amongst other disease biological (genotypic and phenotypic) behaviors. This review explores the quasi-neoplastic or cancer-like properties of keloids and highlights areas for future study.

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Section: Keloids: Scars or Cancerous Tumors?mentioning

confidence: 99%

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

2019

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“…Therefore, the aim here was to identify a molecular diagnostic biomarker capable of distinguishing KS from other forms of dermal scarring specially HTS and also dermatofibrosarcoma protuberans (DFSPs)-an uncommon progressive, reticular dermal neoplasm with high recurrence. Often, keloid and/or DFSP are misdiagnosed (Kimura et al, 2014, Nguyen et al, 2002, Nicholas and Stodell, 2014, Suarez et al, 2015. We have demonstrated immune upregulation and the presence of lymphoid aggregates while investigating the presence of plasma cells in 63 KS tissue samples (Bagabir et al, 2012) using immunohistochemistry, and serendipity that led to the identification of abundant expression of CD138 in KS.…”

Section: To the Editormentioning

confidence: 87%

Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue

Bagabir

Syed

Shenjere

et al. 2016

Journal of Investigative Dermatology

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first year that cutaneous warts on the hands were assessed, were included in this analysis (Melski et al., 1977; Stern et al., 1979). The Mann-Whitney (Wilcoxon) twosample test for medians and Student t test for means were used to test for statistical significant differences between groups. Poisson regression was used to calculate the association of developing subsequent SCCs or BCCs with the presence of cutaneous hand warts in 1985e1986 and other risk factors. Age, sex, geographic location, and population incidence rates were used to calculate expected number of tumors (Scotto et al., 1974; Stern et al., 1979). We performed a univariate analysis of the association of cutaneous warts with previous history of SCC or BCC, level of exposure to PUVA up to the year 1985, high UVB exposure (300 treatments or more), high doses of methotrexate (if given for 36 or more months), and high doses of cyclosporine (if given for 2 or more years). Factors significant on univariate analysis were included in the multivariable model.

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“…In the differential diagnosis, dermatofibrosarcoma protuberans, squamous cell carcinoma, and basal cell carcinoma are mentioned, especially in cases that do not respond to treatment. [13][14][15][16]…”

Section: Discussionmentioning

confidence: 99%

Ulcerated Keloid Secondary to a Coexisting Complicated Epidermal Inclusion Cyst: A Sonographic Diagnosis

Pérez-Wilson

Whittle

García

et al. 2020

Journal of Diagnostic Medical Sonography

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Keloid is a benign fibroblastic tumor that is most often secondary to tissue injury. The clinical presentation is a hard red or purple tumor, mostly itchy or painful. The clinical objectives are to report an ulcerated keloid secondary to a central or inner complicated epidermal inclusion cyst histologically proven and to describe the sonographic findings that permitted the diagnosis. A 29-year-old man with multiple large keloids on the chest wall presented with a two-day pain history, increased volume, and ulceration on one side. Physical examination showed a keloid with edema, peripheral erythema, and a 1-cm central ulcer with purulent discharge. On the sonogram, multiple solid dermal hypodermal pseudotumors were visualized. The lesions were well-defined hypoechogenic heterogeneous solid masses that were hypovascular with color Doppler, concordant with keloids. Within the ulcerated enlarged mass, a complicated epidermal inclusion cyst was discovered with inflammatory changes. The significance of this case lies in the very low frequency of ulceration of a keloid and the high diagnostic value of sonography to demonstrate the presence of a coexisting epidermal inclusion cyst. In the differential diagnosis of an ulcerated keloid, sonography can assist in achieving a better presurgical approach.

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Dermatofibrosarcoma Protuberans on the Chest with a Variety of Clinical Features Masquerading as a Keloid: Is the Disease Really Protuberant?

Cited by 11 publications

References 5 publications

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies

Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue

Ulcerated Keloid Secondary to a Coexisting Complicated Epidermal Inclusion Cyst: A Sonographic Diagnosis

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