Dermatofitoses: agentes etiológicos, formas clínicas, terapêutica e novas perspectivas de tratamento

Lana, Daiane Flores Dalla; Batista, Bruna Gerardon; Alves, Sydney Hartz

doi:10.4322/2357-9730.68880

Cited by 23 publications

(12 citation statements)

References 75 publications

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“…17-21 Comparing these data with studies conducted in Spain and the United States, we can observe the same etiology for T. rubrum complex and T. mentagrophytes complex. 18,19 It is observed that these dermatophytes are the most common causative agents for nail lesions and are the typical agents in regions with subtropical climate and the southern region of Brazil. 21-23…”

Section: Discussionmentioning

confidence: 99%

Occurrence of dermatophytoses in patients from the Sistema Único de Saúde

Sanguino

Jarros

Negri

2019

An. Bras. Dermatol.

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Background Dermatophytosis is a cutaneous disease caused by filamentous keratinophilic fungi belonging to the genera Trichophyton, Microsporum and Epidermophyton , which present a high prevalence in the general population, being among the most common mycoses affecting about 20% of the world's population. Objective To carry out the epidemiological survey of cases of dermatophytosis in patients from the Sistema Único de Saúde in a regional Laboratory in the period of 5 years (2009 to 2013). Methods A retrospective study (January 2009 to December 2013) was carried out with a qualitative and quantitative design, through the registry book of the laboratory, Mycology Sector, where cases of patients with suspected dermatomycosis were analyzed. Results In a 5-year period, a total of 4467 cases were suspected of having a fungal infection. Of these, 68.74% (3071) cases were of dermatomycosis. In relation to cultures with fungal growth, 12.54% (385 cases) were dermatophyte fungi and 7.97% (245 cases) non-dermatophyte fungi were isolated. Among the species identified, there was a higher prevalence of T. rubrum complex (75%), T. mentagrophytes complex (11.68%) and M. canis (7.01%). Regarding the sites analyzed, nail involvement was the most frequent in 75% of the cases. Study Limitations This work is representative in the studied region. Conclusions Dermatomycosis samples are the most frequent among all samples of fungal infections from these patients, with the nail being the most affected area and the fungi T. rubrum complex and T. mentagrophytes complex the most frequent.

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Section: Discussionmentioning

confidence: 99%

Occurrence of dermatophytoses in patients from the Sistema Único de Saúde

Sanguino

Jarros

Negri

2019

An. Bras. Dermatol.

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“…The condition is caused mainly by T. rubrum , T. mentagrophytes var. interdigitale and Epidermophyton floccosum , and men are more affected than women [ 19 ]. The main causative agent of tinea corporis is T. rubrum , which is responsible for 80 to 90% of infections.…”

Section: Epidemiology Of Infections Caused By Dermatophytesmentioning

confidence: 99%

Epidemiology and Diagnostic Perspectives of Dermatophytoses

Petrucelli

Abreu

Cantelli

et al. 2020

JoF

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Dermatophytoses affect about 25% of the world population, and the filamentous fungus Trichophyton rubrum is the main causative agent of this group of diseases. Dermatomycoses are caused by pathogenic fungi that generally trigger superficial infections and that feed on keratinized substrates such as skin, hair, and nails. However, there are an increasing number of reports describing dermatophytes that invade deep layers such as the dermis and hypodermis and that can cause deep infections in diabetic and immunocompromised patients, as well as in individuals with immunodeficiency. Despite the high incidence and importance of dermatophytes in clinical mycology, the diagnosis of this type of infection is not always accurate. The conventional methods most commonly used for mycological diagnosis are based on the identification of microbiological and biochemical features. However, in view of the limitations of these conventional methods, molecular diagnostic techniques are increasingly being used because of their higher sensitivity, specificity and rapidity and have become more accessible. The most widely used molecular techniques are conventional PCR, quantitative PCR, multiplex PCR, nested, PCR, PCR-RFLP, and PCR-ELISA. Another promising technique for the identification of microorganisms is the analysis of protein profiles by MALDI-TOF MS. Molecular techniques are promising but it is necessary to improve the quality and availability of the information in genomic and proteomic databases in order to streamline the use of bioinformatics in the identification of dermatophytes of clinical interest.

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“…Noteworthy, the drug was not detected in the receptor compartment solution. Compound retained in these outermost layers of the skin is extremely advantageous for the treatment of dermatomycoses, such as dermatophytosis and superficial/cutaneous candidiasis, which have the epidermis as the main site of infection and which are recognised as being difficult to treat . This result brings a more real approximation of its potential therapeutic use.…”

Section: Resultsmentioning

confidence: 99%

“…Dermatophytes are keratinophilic fungi, comprising species of three anamorphic genera— Microsporum , Trichophyton and Epidermophyton . Trichophyton rubrum , Trichophyton mentagrophytes and more recently Microsporum canis have been identified as a biofilm‐forming species, which worsens the therapeutic response .…”

Section: Introductionmentioning

confidence: 99%

Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride

Lana

Lavorato

Giuliani

et al. 2019

Mycoses

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Summary Background Fungal infections are highly prevalent and are responsible for high rates of morbidity and mortality. In this context, the search for new treatment alternatives is very relevant. Objectives Analyse chemical compounds for antifungal potential against dermatomycosis fungi. Methods The antifungal activity of 121 compounds, intermediates or derivatives of 1,3‐bis(aryloxy)propane substituted at C‐2 (111 compounds) and isothiouronium derivatives (10 compounds) was investigated through susceptibility tests, mechanism of action, toxicity and hydrogel incorporation. Results The compound 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride (2j) was the most active fungicide against dermatophytes and Candida spp., at very low concentrations (0.39‐3.12 µg/mL), including action on resistant and multidrug‐resistant clinical strains. Compound 2j has presented a promising toxicity profile, showing selectivity index >10, relative to human lymphocytes. The compound was classified as non‐irritant by the HET‐CAM test and did not cause histopathological alterations in pig ear skin, thus presenting an excellent perspective for topical application. 2j targets the fungal cell wall, which was confirmed by scanning electron microscopy, which also indicated the additional ability of 2j to inhibit the Candida albicans pseudohyphae formation and biofilm of Microsporum canis. Compound 2j was incorporated in a hydrogel with bioadhesive potential. The results of the human skin permeation showed that 2j remained significantly in the epidermis, ideally for the dermatomycosis treatment. Conclusions Therefore, the compound 2j demonstrated the potential for antifungal drug development, with a action mechanism elucidated and already applied in a semisolid formulation as a new therapeutic option for fungal skin infections.

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Dermatofitoses: agentes etiológicos, formas clínicas, terapêutica e novas perspectivas de tratamento

Cited by 23 publications

References 75 publications

Occurrence of dermatophytoses in patients from the Sistema Único de Saúde

Occurrence of dermatophytoses in patients from the Sistema Único de Saúde

Epidemiology and Diagnostic Perspectives of Dermatophytoses

Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride

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