Dermatoglyphic meta-analysis indicates early epigenetic outcomes & possible implications on genomic zygosity in type-2 diabetes

Abstract

Background: Dermatoglyphic studies, particularly those arising from the Dutch Hunger Winter Families Cohort, indicate an involvement of prenatal epigenetic insults in type-2 diabetes. However, the exact orchestration of this association is not fully understood. Herein is described a meta-analysis performed based on a belief that such an approach could shed some light as to the role of genetic & epigenetic influences in the etiology of type-2 diabetes. Methodology/principal findings: The study incorporated reports identified from PubMed, Medline, & Google Scholar databases for eligible case-control studies that assessed dermatoglyphics in type-2 diabetes cases relative to controls. Over 44,000 fingerprints & 2300 palm prints from around 4400 individuals were included in the analysis. Decreased loops patterns [OR= 0.76; 95% CI= (0.59, 0.98)], increased non-loop patterns [OR= 1.31; 95% CI= (1.02, 1.68)], and reduced absolute finger ridge counts [OR= -0.19; 95% CI= (-0.33, -0.04)] were significant findings among the diabetic group. These results are indicative of mild developmental deviances, with epigenetic insults significantly linked to early gestation wherein critical events &signaling pathways of the endocrine pancreas development are witnessed. Further, the increased loop patterns with decreased non-loop patterns were deemed as possible indicators of decreased genomic heterozygosity with concurrently increased homozygosity in the diabetic group, linked to reduced buffering capacities during prenatal development. Conclusions: Epigenetic insults primarily during the 1 st trimester, to a lesser extent between the early-to-mid 2 ndtrimester, but least likely linked to those beyond the mid-second trimester are evident in type-2 diabetes. It is recommended that future research aimed at expounding the prenatal origins of T2DM, as well as developing novel therapeutic methods, should focus on the early stages of endocrine pancreatic development.

Dermatoglyphical impressions are different between children and adolescents with normal weight, overweight and obesity: a cross-sectional study

“…Dermatoglyphics has its fundamental basis in this premise, being an epigenetic marker related to the period of fetal development ( Yohannes, 2015 ). In addition to the fact that the fingerprints are intrinsically related to the central nervous system and can therefore reflect motor capacities inherited genetically and epigenetically for conditions that may have a marker expressed during this period of fetal development, fingerprint evaluation is a simple and practical method ( King et al ., 2009 ).…”

“…The reason for the association between DGFs and health is the influence of epigenetics, which affects both ( Yohannes, 2015 ). The formation of the former begins in the first trimester of pregnancy, during the 6th week, is completed after the 24th week of gestation and is formed according to the development and maturation of the central nervous system ( Babler, 1991 ; King et al ., 2009 ).…”

Diabetic Distress Among Diabetic Patients in the Amhara Regional State, Ethiopia

“…25 Furthermore, numerous studies were also conducted in Ethiopia using various samplesrisk factors and clinical variables. For instance, the physical and medical risk factor of diabetes was studied by, T/Kiros et al, 26 Abebe et al, 13 Gebreyohannes et al, 27 Zekewos et al, 28 Yohanes, 29 and Alemu, 30 in another word, psychological disorder related to diabetes are forgotten.…”

Association between gestational period and obesity in children with the use of dermatoglyphic traits: A preliminary study

“…Dermatoglyphics has its fundamental basis in this premise, since it is an epigenetic marker associated with the period of fetal development [ 37 ]. In the present study, the analysis of the association between BMI, fingerprints and gestational data showed no significant results; however, it was observed that the older the woman when she became pregnant, the greater the number of ridges on the child’s left index and right thumb.…”