Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: A double-blind, placebo-controlled study

Park, Heung-Woo; Park, Changhan; Park, Su-Hwa; Park, Jun Yong; Park, Hyun Sun; Yang, Hyeon Jong; Ahn, Kangmo; Kim, Kyu-Han; Oh, Jae‐Won; Kim, Kyu-Earn; Pyun, Bok‐Yang; Lee, Ha-Baik; Min, Kyung-Up

doi:10.1016/j.jaci.2007.12.1162

Cited by 33 publications

(25 citation statements)

References 7 publications

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“…The results showed that a pseudoallergen‐free diet was beneficial for one‐third of csU patients in the trial. This in contrast to the study of Park and colleagues (47) who found that a mixture of seven common food additives did not cause dermatologic adverse reactions or aggravate atopic dermatitis symptoms in patients with allergic diseases. In a study of children aged 3–17 yr (48), 12/16 (75%) were diagnosed with pseudoallergen‐induced urticaria, occurring mainly to colouring agents and preservatives but also to monosodium glutamate and a sweetener (saccharin/cyclamate).…”

Section: Underlying Causes Of Chronic Spontaneous Urticaria In Childrencontrasting

confidence: 99%

Chronic spontaneous urticaria in children: Itching for insight

Church

Weller

Stock

et al. 2011

Pediatric Allergy Immunology

104

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While there is increasing information about the pathogenesis and treatment of chronic spontaneous urticaria (csU) in adults, there is little published information about csU in children. Consequently, most of the recommendations contained in current guidelines for the prevention and treatment of csU in infants and children is based on extrapolation of data obtained in adults. To rectify this, this review points out critical gaps in our knowledge and suggests strategies which may help us to improve our understanding of this condition. How common is csU in children? What do we know about its clinical presentation and the presence of useful biomarkers? What are its common underlying causes? What is the course of csU in children? How does csU affect the everyday life of children? What treatment options are available for children? To answer these questions, two separate types of information are required. The first is information about the prevalence of the condition in the community at large and how csU affects the everyday life of both the child-patient and the parent or carer. Because most csU cases in infants and children do not come to specialists but are treated by general practitioners or by parents using over-the-counter medications, these questions may be answered only by general population surveys or schools programmes. The second is clinical information including family history and disease presentation, the presence of biomarkers and comorbidities, objective measures of severity, frequency and duration of exacerbations, the response to therapy and the time to remission. Targeted questionnaires need to be developed and validated for these investigations. This has already begun in Germany with the establishment of the CU-KID Netzwerk (Email address: cu-kid@charite.de), the aim of which is to identify clinical centres and colleagues who treat children with urticaria and to initiate the information gathering described above.

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Section: Underlying Causes Of Chronic Spontaneous Urticaria In Childrencontrasting

confidence: 99%

Chronic spontaneous urticaria in children: Itching for insight

Church

Weller

Stock

et al. 2011

Pediatric Allergy Immunology

104

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“…Despite the great number of food additives, only a few have been implicated in adverse reactions and are mainly mediated through non-IgE mediated immunologic or non-immunologic mechanisms [5]. There have been several case reports on urticaria, angioedema, asthmatic reactions and anaphylaxis caused by food additives [8-13,16,17]. In some of these studies, they performed the oral provocation test for food additives and revealed that hypersensitivity to food additives is the cause of CU [5,8,9,33,34].…”

Section: Discussionmentioning

confidence: 99%

“…There have been several case reports on urticaria, angioedema, asthmatic reactions and anaphylaxis caused by food additives [8-13,16,17]. In some of these studies, they performed the oral provocation test for food additives and revealed that hypersensitivity to food additives is the cause of CU [5,8,9,33,34]. However, in these studies, the challenge procedure was executed under poorly controlled circumstances, which were not double-blinded or placebo-controlled.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, tartrazine, benzoate, monosodium glutamate (MSG), sulfite, aspartame, nitrites, salicylate and some colorants have been tipped as the potential culprits for adverse food reactions [5]. Their potential roles in CU pathogenesis have been suggested by a few studies [8-13], but they are still under investigation. The reasons for the lack of evidence could be attributed to the practical difficulty of performing the gold standard test, the double-blind placebo-controlled food challenge (DBPCFC) [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the methodological issues such as inconsistent inclusion criteria and the absence of a standardized challenge protocol exist, and the outcome of the DBPCFC is not always satisfactory [11,16,17]. The skin prick test, which is widely used to screen sensitized allergens, is not useful for discriminating food additives hypersensitivity [13]. Assuming the culprit additive depends solely on the patient's subjective symptoms, which are sometimes vague and provoked by unrelated foods.…”

Section: Introductionmentioning

confidence: 99%

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Basophil Activation Test with Food Additives in Chronic Urticaria Patients

et al. 2014

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The role of food additives in chronic urticaria (CU) is still under investigation. In this study, we aimed to explore the association between food additives and CU by using the basophil activation test (BAT). The BAT using 15 common food additives was performed for 15 patients with CU who had a history of recurrent urticarial aggravation following intake of various foods without a definite food-specific IgE. Of the 15 patients studied, two (13.3%) showed positive BAT results for one of the tested food additives. One patient responded to monosodium glutamate, showing 18.7% of CD203c-positive basophils. Another patient showed a positive BAT result to sodium benzoate. Both patients had clinical correlations with the agents, which were partly determined by elimination diets. The present study suggested that at least a small proportion of patients with CU had symptoms associated with food additives. The results may suggest the potential utility of the BAT to identity the role of food additives in CU.

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Tartrazine exclusion for allergic asthma

Ardern¹

2001

Cochrane Database of Systematic Reviews

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Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: A double-blind, placebo-controlled study

Cited by 33 publications

References 7 publications

Chronic spontaneous urticaria in children: Itching for insight

Chronic spontaneous urticaria in children: Itching for insight

Basophil Activation Test with Food Additives in Chronic Urticaria Patients

Tartrazine exclusion for allergic asthma

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