Dermatologic Diagnosis: Leukocytoclastic Vasculitis

A not‐so‐sweet diagnosis – leukocytoclastic vasculitis masquerading as squamous cell carcinoma

“…The most common clinical manifestation of LCV is painful, itchy, palpable purpura, typically involving the lower limb , although in up to one third of patients, the upper limb and/or trunk are involved . Ulceration and bullae or vesicles, as was present in our patient (Figure A and B), occur less commonly in 10% and 4% of patients, respectively .…”

“…LCV, also known as hypersensitivity vasculitis, is a small‐vessel vasculitis, characterised by the perivascular neutrophilic inflammation of post‐capillary venules . It is a histologically defined diagnosis of exclusion, and cardinal findings include fibrinoid deposition around vessel walls; endothelial swelling; leukocytoclasis, which refers to vascular damage caused by nuclear debris from infiltrating neutrophils; and erythrocyte extravasation .…”

“…It is a histologically defined diagnosis of exclusion, and cardinal findings include fibrinoid deposition around vessel walls; endothelial swelling; leukocytoclasis, which refers to vascular damage caused by nuclear debris from infiltrating neutrophils; and erythrocyte extravasation . Incidence of biopsy‐proven LCV varies from 3 to 4.5 per 100 000 people per year and increases with advancing age. There is no significant gender predilection .…”

Henoch-Schonlein Purpura After Warfarin Usage in an Adult Patient with Mitral Valve Replacement: Case Report

“…Birçok ilaç, enfeksiyon HSP oluşumuna sebep olurken, varfarin kullanı-mına bağlı erişkinlerde görülen HSP vakaları literatürde ender olarak bildirilmiştir. [2][3][4][5]9 İlaç kullanımı ve HSP oluşumu arasındaki sürenin günler (üç gün), aylar ve yıllar (12 yıl) arasında değişmekte olduğu literatürde bildirilmektedir. 10,11 Olgumuza iki ay önce mitral kapak replasmanı operasyonu uygulanmıştı.…”

“…We herein reported an adult case with HSP after warfarin usage in 51-years old man who has undergone mitral valve replacement two months ago. [3][4][5]9 Bu çalışmada, iki ay önce mitral kapak replasmanı olan ve varfarin kullanımı sonrası HSP ortaya çıkan 51 yaşındaki olgu sunulmuştur. Daha önce-den literatürde varfarine bağlı az sayıda erişkin HSP hastasına rastlandığı ve Türk indeksinde böyle bir vakaya rastlanmadığı için bu çalışma sunuma uygun görülmüştür.…”