Dermatologic manifestations and complications of COVID-19

Gottlieb, Michael; Long, Brit

doi:10.1016/j.ajem.2020.06.011

Cited by 102 publications

(168 citation statements)

References 39 publications

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“…Acute limb ischemia (ALI) is an important consideration in patients with COVID-19 [ 26 ]. There have been over a dozen case reports and case series of ALI described in the literature [ [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] ].…”

Section: Discussionmentioning

confidence: 99%

Thrombotic complications of COVID-19

Avila

Long

Holladay

et al. 2021

The American Journal of Emergency Medicine

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122

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Introduction The novel coronavirus disease of 2019 (COVID-19) is associated with significant morbidity and mortality. The impact of thrombotic complications has been increasingly recognized as an important component of this disease. Objective This narrative review summarizes the thrombotic complications associated with COVID-19 with an emphasis on information for Emergency Medicine clinicians. Discussion Thrombotic complications from COVID-19 are believed to be due to a hyperinflammatory response caused by the virus. Several complications have been described in the literature. These include acute limb ischemia, abdominal and thoracic aortic thrombosis, mesenteric ischemia, myocardial infarction, venous thromboembolism, acute cerebrovascular accident, and disseminated intravascular coagulation. Conclusion It is important for Emergency Medicine clinicians to be aware of the thrombotic complications of COVID-19. Knowledge of these components are essential to rapidly recognize and treat to reduce morbidity and mortality in these patients.

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Section: Discussionmentioning

confidence: 99%

Thrombotic complications of COVID-19

Avila

Long

Holladay

et al. 2021

The American Journal of Emergency Medicine

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122

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“…Potential causes of each dermatological findings Scarlet fever, measles, rubella, medication reaction, secondary syphilis, heat rash, leukemia, graft-versus-host disease Urticaria Allergic reaction, anaphylaxis, angioedema, autoimmune disease (e.g., systemic lupus erythematosus), hypereosinophilia, chronic urticaria, malignancy Vesicular Varicella zoster (i.e., chicken pox), herpes zoster (i.e., shingles), herpes simplex, Rhus dermatitis (e.g., poison ivy, poison oak, and poisonReproduced with permission from Elsevier LTD. The following original report is credited: Gottlieb et al97 DIC, disseminated intravascular coagulation.…”

mentioning

confidence: 99%

Cutaneous Manifestations of COVID-19: A Systematic Review

Singh

Kaur

Singh

et al. 2021

Advances in Wound Care

133

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Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requires knowledge of all possible disease manifestations in affected patients. This Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant review focuses on cutaneous manifestations reported in COVID-19 patients. Approach: Literature review was conducted using the PubMed database to examine various cutaneous manifestations related to the SARS-CoV-2 infection. Published articles (n = 56) related to search criteria from the onset of the COVID-19 pandemic to June 30, 2020, were included. The primary literature articles included in this study were mainly from France, Spain, Italy, and the United Kingdom. Results: Unique to many other symptoms of COVID-19, its cutaneous manifestations have been found in people of all age groups, including children. The cutaneous manifestations of COVID-19 are varied and include maculopapular, chilblain-like, urticarial, vesicular, livedoid, and petechial lesions. In addition, rashes are common in multisystem inflammatory syndrome in children, a new and serious health condition that shares symptoms with Kawasaki disease and is likely related to COVID-19. In addition, personal protective equipmentrelated skin wounds are of serious concern since broken cutaneous barriers can create an opening for potential COVID-19 infections. Innovation and Conclusion: As this virus continues to spread silently, mainly through asymptomatic carriers, an accurate and rapid identification of these cutaneous manifestations may be vital to early diagnosis and lead to possible better prognosis in COVID-19 patients. This systematic review and photo atlas provide a detailed analysis of the skin pathologies related to COVID-19. Study of these cutaneous manifestations and their pathogenesis, as well their significance in human health will help define COVID-19 in its entirety, which is a prerequisite to its effective management.

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“…There have been multiple case reports and case series outlining dermatologic manifestations of COVID-19. The previously described exanthems include vesicular, pernio (chilblain)-like lesions, livedo reticularis, urticarial, petechial, and maculopapular [2,5,[7][8][9][10][11]. These viral exanthems have been described to occur throughout various stages of the disease and do not correlate well with severity of illness [4].…”

Section: Discussionmentioning

confidence: 99%

“…These viral exanthems have been described to occur throughout various stages of the disease and do not correlate well with severity of illness [4]. While many cases have reported dermatologic symptoms prior to respiratory symptoms, the majority of studies have suggested onset a few days after other symptoms [2].…”

Section: Discussionmentioning

confidence: 99%

“…Coronavirus 2019 (COVID-19)is a novel virus thought to infect cells through angiotensin-converting enzyme 2 (ACE2) receptors which can be found on multiple organ systems, including skin [1]. There have been multiple reports of cutaneous manifestations of the disease ranging from pernio (chilblain)-like lesions to urticarial rashes [2]. Below, the authors discuss a case of COVID-19 triggered EN.…”

Section: Introductionmentioning

confidence: 99%

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Erythema nodosum-like rash in a COVID-19 patient: A case report

Sipfle

Bridwell

Roper

2021

The American Journal of Emergency Medicine

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Coronavirus 2019 (COVID-19) is a viral disease first described in Wuhan, China, which has quickly emerged as a global pandemic with a myriad of manifestations including dermatologic (Li My et al., n.d.; Gottlieb and Long, 2020 [1,2]). A variety of cutaneous symptoms have presented throughout various stages of the disease (Marzano, 2020; Recalcati, n.d.; Henry et al., n.d.; Fernandez-Nieto et al., n.d.; Quintana-Castanedo et al., n.d. [3-5,7,8]). We describe a case of a female patient who presented with an Erythema Nodosum-like exanthema likely secondary to COVID-19. The patient described tested positive for COVID-19 three days prior to presentation for the rash with minimal other symptoms of COVID-19. Given the high infectivity rate as well as multisystem presentation, it is important to continue to report on novel presentations of the virus for early identification and treatment of complications.

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Dermatologic manifestations and complications of COVID-19

Cited by 102 publications

References 39 publications

Thrombotic complications of COVID-19

Thrombotic complications of COVID-19

Cutaneous Manifestations of COVID-19: A Systematic Review

Erythema nodosum-like rash in a COVID-19 patient: A case report

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