Dermatologic Manifestations as Indicators of Immune Status in HIV/AIDS

Levy, Tamsin H.; Jacobson, D

doi:10.1007/s11606-011-1743-4

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…In this study, 95.2% of patients had mucocutaneous lesions, among which the most common ones were xerosis, seborrheic dermatitis, HSV infection, and oral candidiasis. These results were in accordance with the studies reported by Levy et al, Foroughi et al, Josephine et al and Noruka et al [ 1 , 8 , 9 , 18 ].…”

Section: Discussionsupporting

confidence: 94%

“…e present research also found oral candidiasis to be a mucocutaneous disorder with significant association with low CD4 counts, which is consistent with previous studies [8,9,[21][22][23][24]. Furthermore, a statistically significant association was found between furuncle and low CD4 counts, which was compatible with Uthayakumar's research [25].Nevertheless, Ali Azfar et al could not show any association between skin manifestations and CD4 cell counts [20].…”

Section: Discussionsupporting

confidence: 92%

“…Josephine et al reported generalized pruritus, vaginal candidiasis, and herpes zoster as the most prevalent skin manifestations in 384 HIV-infected patients and found herpes zoster and candidiasis to be significantly associated with low CD4 counts [8]. ese results were supported by Levy and Jacobson who observed candidiasis in cases with CD4 counts of below 300 [9].In ailand, Wiwantikit reported single or multiple skin disorders in 80% of 120 HIV-positive patients and found xerosis, candidiasis, seborrheic dermatitis, and pruritic rashes as the most common mucocutaneous presentations [10]. In another study by Kim et al, Kaposi sarcoma was associated with CD4 counts <200, while warts were associated with CD4 counts >200 in HIV-positive patients [11], which was compatible with the results of previous studies [12,13].…”

Section: Introductionmentioning

confidence: 87%

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Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

et al. 2020

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Background. More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations. Objective. This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells. Methods. A cross-sectional study was conducted on eighty-four HIV-positive patients, who attended the Behavior Consultation Center of Arak University of Medical Sciences. All subjects had a complete physical examination by an expert dermatologist. Further diagnostic procedures were performed, if necessary. Counts of CD4 were determined using flow cytometry. Results. From 84 patients who enrolled in this study, 95.2% manifested at least one type of mucocutaneous lesions. The most common presentation was xerosis, followed by seborrheic dermatitis, herpes simplex, and oral candidiasis. Oral candidiasis and furuncle were significantly associated with decrease in CD4 cell counts. Conclusions. Cutaneous manifestations are common in HIV-positive patients, some of which (oral candidiasis and furuncle) could be applicable as useful clinical indicators to predict the immune status of the patients. Therefore, regular skin examinations are recommended as routine HIV-infected patients’ healthcare programs.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 87%

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Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts

et al. 2020

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“…about 380-450 cells/cumm. 11,20 Among the participants, most dermatologic manifestations were either infectious or noninfectious seen in the second phase of the disease. 21 A study from Nigeria showed that dermatologic manifestations were commonly seen in phases 2 and 3.…”

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confidence: 99%

Dermatological Manifestations of HIV/AIDS Patients

Khondker

2019

J Enam Med Col

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Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/ AIDS) is a global pandemic. According to Global HIV & AIDS statistics 2018, approximately 36.9 million people are living with HIV globally, 77.3 million [59.9 million–100 million] people have become infected with HIV since the start of the epidemic, 35.4 million [25.0–49.9 million] people died from AIDS-related illnesses since the start of the epidemic and 940000 [670000–1.3 million] people died from AIDS-related illnesses in 2017. It weakens a person’s immune system by destroying important cells that fight disease and infection. Dermatologic diseases are common in the HIV-infected population. Skin disease can be uniquely associated with HIV disease and many of the cutaneous diseases are not unique to this group, but the presentation can be more severe and recalcitrant to treatment. The spectrum of skin conditions includes skin findings associated with primary HIV infection and a broad range of skin problems related to the immune deficiency of advanced AIDS. Recognition of characteristic eruptions can facilitate early diagnosis of HIV. A broad variety of neoplastic, infectious and non-infectious diseases can manifest in the skin and may alert the clinician of declining of the immune system. This article reviews the current spectrum of HIV-associated skin conditions, focusing on common complaints, infections, drugassociated toxicity and malignancies based on recently published literature relevant to this area. J Enam Med Col 2019; 9(3): 185-188

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“…Levy and Jacobson state, dermatological manifestations among patients with HIV may provide insight into their immune status. 1 Herpes zoster, a common problem, may also be a manifestation of the immune reconstitution inflammatory syndrome (IRIS). 2 According to a study published in 2005, HIV-positive patients were more likely to develop shingles after six months or less of treatment with effective highly active antiretroviral therapy, after restoration of immunity.…”

mentioning

confidence: 99%