Dermatologic manifestations in patients with polycystic ovary syndrome: their prevalence and assessment in relation to hormonal and metabolic changes

Gaber, Hend Hassan; Abuzeid, Sami Abdelhamid; Abukhedr, Nouran Abdelaziz; gaafar, sherif; Bondok, Maha

doi:10.21608/alexpo.2020.49095.1070

Cited by 1 publication

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“…In our study we found that there is no significant difference in IFNγ in test and control group of patients and couldn't find any significant relationship of IFN-γ with insulin level or IR either. This shows that IR in PCOS pathophysiology could be related by IFN-γ free pathway and it is strongly backed up by another latest research done by Juan et al about the importance of other marker like leptin taking part in process of PCOS highlighting the importance of the connection between leptin and inflammation in PCOS providing new insights therapeutic strategy for this disease (34). Several studies have proposed many pro-inflammatory molecules play a role in the complex inflammatory cascade that is associated with PCOS (31,33).…”

Section: Methodsmentioning

confidence: 92%

Potential Pathophysiology Through High Gonadal Hormone Profile and Peripheral Insulin Resistance, Circumventing IFN γ Effects in Women With Polycystic Ovary Syndrome

Hettihewa¹,

Weerasinghe²

2020

CINEC Acad. J.

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Heterogeneous Polycystic ovary syndrome (PCOS) is a low grade inflammatory diseases common with many of the young female and strongly associated with peripheral insulin resistance. Our study focused on investigating the effects of interferon gamma (IFN γ) in control of IR in obese PCOS patients with matched control. PCOS patients diagnosed by Rotterdam criteria and BMI matched controls were checked for Fasting insulin and IFNγ, FSH, LH, prolactin, testosterone, triglycerides and glucose levels and IR was calculated by Homeostasis Model Assessment (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI) and McAuley (McA) index. Fasting glucose, insulin, and IR by QUICKI, HOMA-IR and McA is higher in obese PCOS in compared to control. High serum testosterone, LH, and FSH levels were also observed in women with PCOS. But IFNγ is not statistically significant and not correlated significantly with fasting insulin (ρ = -0.004), HOMA-IR (ρ = -0.02), QUICKI (ρ = -0.11) or McA (ρ = -0.15) in obese women with PCOS. We suggest that development of peripheral insulin resistance in PCOS is not through the mediation of IFNγ. Further studies are needed to prove the suggested mechanism and to develop drugs for reversing PCOS pathology.

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Section: Methodsmentioning

confidence: 92%