2019
DOI: 10.1097/dad.0000000000001412
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Dermatological Implications of Galectin-3 in Circulation: An Evaluation From the Perspective of Patients With Differential Manifestations of Post–Kala-Azar Dermal Leishmaniasis

Abstract: Galectin-3, a β-galactoside–binding lectin, has been implicated in vast repertoire of inflammatory and immunomodulatory processes including skin diseases. However, galectin-3 has not been comprehensively studied in infectious diseases. This study emphasizes on fascinating aspects of galectin-3 expression in dermal infection by studying post–kala-azar dermal leishmaniasis (PKDL), an intracellular infection caused by Leishmania donovani. Indian PKDL is a well-recognized parasitic dermatosis, with a high risk of … Show more

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“…Gal-3 recognizes non-self glycan on the parasite surface; it is considered a pattern recognition receptor (PRR). However, released Gal-3 is found in lesions associated with pathogen infection and modulates the innate immune response, being also considered a DAMP [81,82].…”
Section: The Role Of Galectins In Leishmaniasismentioning
confidence: 99%
“…Gal-3 recognizes non-self glycan on the parasite surface; it is considered a pattern recognition receptor (PRR). However, released Gal-3 is found in lesions associated with pathogen infection and modulates the innate immune response, being also considered a DAMP [81,82].…”
Section: The Role Of Galectins In Leishmaniasismentioning
confidence: 99%