Dermatological manifestations of hematologic neoplasms. Part I: secondary specific skin lesions

Souza, Patricia Karla de; Amorim, Rafael Oliveira; Sousa, Letícia Siqueira; Batista, Mariana Dias

doi:10.1016/j.abd.2022.06.002

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…In most patients, the skin lesions are asymptomatic, but occasionally, pain or pruritus may be present [5,29]. The development of LC is more likely to be rapid in acute leukemias but more gradual in chronic leukemias [30]. The appearance of the skin lesions in LC is nonspecific, which makes it difficult to clinically differentiate from other skin lesions [13,31,32].…”

Section: Diagnosismentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.

show abstract

Section: Diagnosismentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

View full text Add to dashboard Cite

show abstract

“…In most patients, the skin lesions are asymptomatic, but occasionally pain or pruritus may be present [5,28]. The development of LC is more likely to be rapid in acute leukemias, but more gradual in chronic leukemias [29]. The appearance of the skin lesions in LC is nonspecific, which makes it difficult to clinically differentiate from other skin lesions [18,30,31] .…”

Section: Diagnosismentioning

confidence: 99%

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

Robak,

Braun,

Robak

2023

Preprint

View full text Add to dashboard Cite

Leukemia cutis (LC) is defined as leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and in T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis and treatment of leukemic skin involvement in different types of leukemia

show abstract