Dermatological Toxicity of Hexavalent Chromium

Shelnutt, Susan R.; Goad, Phillip; Belsito, D.

doi:10.1080/10408440701266582

Cited by 105 publications

(73 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As enter the 21st century, many investigators have attempted to identify non-sensitizing levels of chromium, and some European economic union countries have adopted restrictions stating that the concentration of chromium in various products must be below the detection limit 11 . Currently, the analytic detection limit is approximately 3 mg per kg (ppm) in leather, whereas in our case, the analyzed chromium content in the glove was 308.91 ppm, about one hundred times higher than that of the detection limit.…”

Section: Discussionmentioning

confidence: 99%

A Case of Chromium Contact Dermatitis due to Exposure from a Golf Glove

et al. 2010

View full text Add to dashboard Cite

Chromium is a transition metal and has been shown to elicit contact dermatitis. Although leather products have been known to be the most significant source of chromium exposure these days, the majority of reports have been related to exposure from shoe products. We herein report a professional golfer who became allergic to golf gloves made of chromium-tanned leather. A 27-year-old woman golfer presented with recurrent, pruritic, erythematous plaques that had been occurring on both hands for several years. The lesions developed whenever she had worn golf gloves for an extended period of time, especially during tournament season. To identify the causative agent, patch tests were performed and the results demonstrated a strong positive reaction to potassium dichromate 0.5% and to her own glove. The amount of chromium in her golf glove was analyzed to be 308.91 ppm and based on this, a diagnosis of allergic contact dermatitis due to a chromium-tanned leather glove was made. She was treated with oral antihistamines combined with topical steroids and advised to wear chromium-free leather gloves. There has been no evidence of recurrence during a six month follow-up period. (Ann Dermatol 22(1) 63∼65, 2010)

show abstract

Section: Discussionmentioning

confidence: 99%

A Case of Chromium Contact Dermatitis due to Exposure from a Golf Glove

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Treating cells cultured in vitro with hexavalent chromium resulted in cytotoxicity [1], genotoxicity [2], apoptosis [3], and cell transformation [4]. Similarly, administration of hexavalent chromium to experimental animals results in toxicity of the lungs [5], kidney [6], skin [7], and reproductive system [8]. Epidemiological evidence is also available to demonstrate the toxicity of hexavalent chromium in humans [9].…”

Section: Introductionmentioning

confidence: 99%

“…Even though the principal route of human exposure to chromium is through inhalation, and lung has been identified as the primary target organ for its toxicity [11], significant human exposure to chromium also takes place through the skin [7]. In addition, skin is a major target organ for chromium toxicity [7,11].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics Evaluation of Hexavalent Chromium Toxicity in Human Dermal Fibroblasts

Sellamuthu¹,

Umbright²,

Chapman³

et al. 2011

J Carcinogene Mutagene

View full text Add to dashboard Cite

“…Cr hypersensitivity is one of the major occupational metal skin diseases especially in cement workers [2,3]. Cr hypersensitivity is common in the general population with a prevalence of approximately 0.5% [4,5], whereas the prevalence in cement workers is approximately 4.5% [4,6].…”

Section: Introductionmentioning

confidence: 99%

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Shigematsu¹,

Kumagai²,

Kobayashi³

et al. 2014

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or allergic contact dermatitis. However, accumulating T cells during development of metal allergy are poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing of T-cell receptor (TCR) repertoire and cytokine profiles in accumulated T cells in inflamed skin during elucidation of Cr allergy. A novel model of Cr allergy was induced by two sensitizations of Cr plus lipopolysaccharide solution into mouse groin followed by single Cr challenge into the footpad. TCR repertoires and nucleotide sequences of complementary determining region 3 were assessed in accumulated T cells from inflamed skin. Cytokine expression profiles and T-cell phenotypes were determined by qPCR. CD3+CD4+ T cells accumulated in allergic footpads and produced increased T helper 1 (Th1) type cytokines, Fas, and Fas ligand in the footpads after challenge, suggesting CD4+ Th1 cells locally expanded in response to Cr. Accumulated T cells included natural killer (NK) T cells and Cr-specific T cells with VA11-1/VB14-1 usage, suggesting metal-specific T cells driven by invariant NKT cells might contribute to the pathogenesis of Cr allergy.

show abstract

Dermatological Toxicity of Hexavalent Chromium

Cited by 105 publications

References 54 publications

A Case of Chromium Contact Dermatitis due to Exposure from a Golf Glove

A Case of Chromium Contact Dermatitis due to Exposure from a Golf Glove

Transcriptomics Evaluation of Hexavalent Chromium Toxicity in Human Dermal Fibroblasts

Accumulation of metal-specific T cells in inflamed skin in a novel murine model of Chromium-induced allergic contact dermatitis

Contact Info

Product

Resources

About