Dermatology in a multidisciplinary approach with infectious disease and obstetric medicine against COVID-19

Lim, Rachel; Kalagara, Saisanjana; Chen, Kenneth K.; Mylonakis, Eleftherios; Kroumpouzos, George

doi:10.1016/j.ijwd.2021.08.008

Cited by 5 publications

(5 citation statements)

References 76 publications

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“…General practitioners should be aware of such reactions and can play an important role in patient counseling. Lastly, the appropriate identification and management of vaccine reactions often requires a multispecialty approach involving dermatology, allergy, and infectious disease specialists [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

et al. 2022

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Because of the increasing emergence of cutaneous reactions from COVID-19 vaccines worldwide, we investigated the published reports of these complications. We searched the PubMed, Google Scholar, and Scopus databases and the preprint server bioRxiv for articles on cutaneous complications linked to mRNA-1273 (Moderna), BNT162b2 (Pfizer–BioNTech), and AZD1222 (AstraZeneca–Oxford University) vaccines published until 30 September 2021. Eighty studies describing a total of 1415 reactions were included. Cutaneous reactions were more prevalent in females (81.6%). Delayed large local reactions were the most common complication (40.4%), followed by local injection site reactions (16.5%), zoster (9.5%), and urticarial eruptions (9.0%). Injection site and delayed large local reactions were predominantly caused by the mRNA-1273 vaccine (79.5% and 72.0%, respectively). BNT162b2 vaccination was more closely linked to distant reactions (50.1%) than mRNA-1273 (30.0%). Zoster was the most common distant reaction. Of reactions with adequate information for both vaccine doses, 58.3% occurred after the first dose only, 26.9% after the second dose only, and 14.8% after both doses. Overall, a large spectrum of cutaneous reaction patterns occurred following the COVID-19 vaccination. Most were mild and without long-term health implications. Therefore, the occurrence of such dermatologic complications does not contraindicate subsequent vaccination.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

et al. 2022

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“…However, most COVID-19 symptoms developed on the skin, including periocular inflammation, ischemia, livedo reticularis and petechiae, and purpura, are more frequently reported in severe cases, compared to other manifestations, including vesiculobullous, ecchymosis, and maculopapular exanthema. During pregnancy, there is a higher risk of complications from COVID-19, and the hormonal and immune changes during this period would also impact the skin manifestations of COVID [26,27]. Such data allude to a link between COVID-19 and its effect on the skin.…”

Section: Cutaneous Manifestations In Children and Pregnant Womenmentioning

confidence: 99%

The Pandemic and Your Skin—Direct and Indirect Impact of COVID-19

et al. 2023

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Apart from well-known respiratory symptoms, less frequent symptoms also appear as a direct result of COVID-19 infection, or as indirect effects of the recommended quarantine and related lifestyle changes. The impact of the COVID-19 pandemic on human skin is predominantly focused on in this article. Cutaneous manifestations, including redness, chilblain-like symptoms (COVID toes), hives or urticaria rash, water blisters, and fishing net-like red-blue patterns on the skin, may appear as accompanying or as systemic COVID-19 symptoms with potential lesions at different skin sites. These symptoms were related to skin phototypes and vitamin D deficiency. Moreover, Black, Asian, and minority ethnic origin patients are found to be more sensitive to COVID-19 infection than Caucasians because of vitamin D deficiency. The region of population with lighter skin phototypes have a significantly higher chance to develop cutaneous manifestations than population with dark skin. In addition, adverse effects, such as skin barrier damage and irritation, may also occur due to extensive personal protective equipment usage (e.g., masks, protective suits, and a few others) and predominately alcohol-based sanitizers. This manuscript covers various aspects of COVID-19 and its clinical skin manifestations.

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Section: Reviewmentioning

confidence: 99%

“…Dermatologists, geneticists, immunologists, and other experts work together to develop tailored treatment plans and long-term management strategies for individuals with Dubowitz syndrome and pyoderma gangrenosum. These reports provide insights into the comprehensive care provided to address the complex needs of patients, considering the underlying genetic factors, immune dysregulation, and potential comorbidities [28]. Long-term outcomes and quality of life: Under various management strategies, research should assess the long-term outcomes and quality of life of individuals with Dubowitz syndrome and pyoderma gangrenosum.…”

Section: Case Studies or Examples Of Treatment Approachesmentioning

confidence: 99%

Pyoderma Gangrenosum: A Challenging Cutaneous Manifestation in Dubowitz Syndrome

Ghode¹,

Kenjale²,

Heda³

et al. 2023

Cureus

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Pyoderma gangrenosum (PG) is a challenging cutaneous manifestation associated with Dubowitz syndrome, a rare genetic disorder characterized by multiple congenital anomalies, developmental delay, and distinctive facial features. This review article aims to provide a comprehensive overview of the association between Dubowitz syndrome and pyoderma gangrenosum, emphasizing the clinical presentation, challenges in diagnosis and management, and potential underlying mechanisms. A comprehensive literature search was conducted to gather relevant studies, and inclusion and exclusion criteria were applied to select appropriate articles. The association between Dubowitz syndrome and pyoderma gangrenosum has been documented in reported cases and studies. Clinical characteristics of Pyoderma gangrenosum in Dubowitz syndrome include painful necrotic ulcers with undermined borders. Diagnosing pyoderma gangrenosum in the context of Dubowitz syndrome can be challenging due to the overlapping clinical features and complexities associated with the syndrome. Managing pyoderma gangrenosum involves a multidisciplinary approach, with general principles of wound care, systemic therapy, and pain management. Specific considerations for treating pyoderma gangrenosum in Dubowitz syndrome include collaboration among specialists and careful monitoring. Future directions for management include further research to understand the underlying mechanisms and develop targeted therapies. Recognizing and addressing pyoderma gangrenosum in Dubowitz syndrome is crucial for optimal patient care. This review enhances awareness among healthcare professionals and provides insights for improving diagnosis, management, and treatment outcomes for individuals with this challenging combination of conditions.

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Dermatology in a multidisciplinary approach with infectious disease and obstetric medicine against COVID-19

Cited by 5 publications

References 76 publications

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

The Pandemic and Your Skin—Direct and Indirect Impact of COVID-19

Pyoderma Gangrenosum: A Challenging Cutaneous Manifestation in Dubowitz Syndrome

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