Dermatology in South Vietnam*

Palmer, Alice E.; Ut, Nguyen Van; Nguyen, Nhiem

doi:10.1111/j.1365-4362.1970.tb04723.x

Cited by 13 publications

(2 citation statements)

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“…Interactions between UV and molecular components of the epidermis and dermis cause acute and chronic cutaneous changes called photoageing 2. Chronic exposure of human skin to UVB radiation induces the production of reactive oxygen species (ROS) and matrix metalloproteinases (MMPs) 3.…”

Section: Introductionmentioning

confidence: 99%

Dihydroavenanthramide D prevents UV‐irradiated generation of reactive oxygen species and expression of matrix metalloproteinase‐1 and ‐3 in human dermal fibroblasts

Kim

Noh

Kwon

et al. 2013

Experimental Dermatology

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Ultraviolet B (UVB) radiation induces photoageing by upregulating the expression of matrix metalloproteinases (MMPs) in human skin cells. Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component in oats. Although anti-inflammatory, anti-atherosclerotic and antioxidant effects have been reported, the antiphotoageing effects of DHAvD are yet to be understood. In this study, we investigated the inhibitory effects of DHAvD on UVB-induced production of reactive oxygen species (ROS) and expression of MMPs, and its molecular mechanism in UVB-irradiated human dermal fibroblasts. Western blot and real-time PCR analyses revealed that DHAvD inhibited UVB-induced MMP-1 and MMP-3 expression. It also significantly blocked UVB-induced ROS generation in fibroblasts. Additionally, DHAvD attenuated UVB-induced phosphorylation of MAPKs, activation of NF-κB and AP-1. DHAvD regulates UVB-irradiated MMP expression by inhibiting ROS-mediated MAPK/NF-κB and AP-1 activation. DHAvD may be a useful candidate for preventing UV light-induced skin photoageing.

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Section: Introductionmentioning

confidence: 99%

Dihydroavenanthramide D prevents UV‐irradiated generation of reactive oxygen species and expression of matrix metalloproteinase‐1 and ‐3 in human dermal fibroblasts

Kim

Noh

Kwon

et al. 2013

Experimental Dermatology

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“…Applications of antioxidants as preservatives in skin-protective ingredients in cosmetics are also receiving increasing attention and interest. 15,16) Developing tyrosinase inhibitors with potent antioxidation may be a feasible way to balance skin brightening and side effects.…”

mentioning

confidence: 99%

Antioxidation and Tyrosinase Inhibition of Polyphenolic Curcumin Analogs

Jiang

Zhikai

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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A series of polyphenolic curcumin analogs were synthesized and their inhibitory effects on mushroom tyrosinase and the inhibition of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical formation were evaluated. The results indictated that the analogs possessing m-diphenols and o-diphenols exhibited more potent inhibitory activity on tyrosinase than reference compound rojic acid, and that the analogs with o-diphenols exhibited more potent inhibitory activity of DPPH free-radical formation than reference compound vitamin C. The inhibition kinetics, analyzed by Lineweaver-Burk plots, revealed that compounds B(2) and C(2) bearing o-diphenols were non-competitive inhibitors, while compounds B(11) and C(11) bearing m-diphenols were competitive inhibitors. In particular, representative compounds C(2) and B(11) showed no side effects at a dose of 2,000 mg/kg in a preliminary evaluation of acute toxicity in mice. These results suggest that such polyphenolic curcumin analogs might serve as lead compounds for further design of new potential tyrosinase inhibitors.

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Bibliography of Secondary Sources on the History of Dermatology

Parish

1976

Int J Dermatology

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Dermatology in South Vietnam*

Cited by 13 publications

References 1 publication

Dihydroavenanthramide D prevents UV‐irradiated generation of reactive oxygen species and expression of matrix metalloproteinase‐1 and ‐3 in human dermal fibroblasts

Dihydroavenanthramide D prevents UV‐irradiated generation of reactive oxygen species and expression of matrix metalloproteinase‐1 and ‐3 in human dermal fibroblasts

Antioxidation and Tyrosinase Inhibition of Polyphenolic Curcumin Analogs

Bibliography of Secondary Sources on the History of Dermatology

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