Dermatomyositis and Punctate Porokeratotic Keratoderma as Paraneoplastic Syndrome of Ovarian Cancer

Valverde, R.; Sánchez-Caminero, M.P.; Calzado, L.; Frutos, F.J. Ortiz de; Rodríguez‐Peralto, José Luis; Vanaclocha, F.

doi:10.1016/s1578-2190(07)70462-6

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…Of the 58 articles, 10 were case series, resulting in 84 SpK cases for analysis (Table 1). The individual cases were published in the USA (32), 1,3,8,9,12,16,18,20,24,[30][31][32][33][34]37,45,47,49,53 Spain (12), 14,22,23,26,28,29,36,39,50,54,58 Saudi Arabia (7), 10 Italy (6), 2,13,19,46,55 Japan (6), 11,21,25,40,52 Brazil (4), 5,42 United Kingdom (3), 41,57 Australia…”

Section: Resultsmentioning

confidence: 99%

“…There were three cases of chronic lymphocytic leukemia, 22,28,55 three of lung cancer, 6,13,30 two of colorectal cancer, 2,5 two of melanoma, 15,35 two of renal cell carcinoma, 45,58 four of nonmelanoma skin cancer, 18,43,44,55 one of gingival squamous cell carcinoma, 25 one of multiple myeloma, 42 one of endometrial carcinoma, 50 one of hepatocellular carcinoma, 23 one of breast cancer, 53 one tumor of the esophagus, 21 one of myelofibrosis, 57 and one of ovarian cancer. 26…”

Section: Resultsmentioning

confidence: 99%

“…Of the 58 articles, 10 were case series, resulting in 84 SpK cases for analysis (Table 1). The individual cases were published in the USA (32), 1,3,8,9,12,16,18,20,24,30–34,37,45,47,49,53 Spain (12), 14,22,23,26,28,29,36,39,50,54,58 Saudi Arabia (7), 10 Italy (6), 2,13,19,46,55 Japan (6), 11,21,25,40,52 Brazil (4), 5,42 United Kingdom (3), 41,57 Australia (3), 43,56 India (2), 48,51 Germany (2), 35,44 Israel (1), 27 Turkey (1), 4 France (1), 17 Scotland (1), 38 Austria (1), 15 South Africa (1), 7 and Canada (1) 6 . Of the 84 total cases, 33 (39.3%) were female and 51 (60.7%) were male.…”

Section: Resultsmentioning

confidence: 99%

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Spiny keratoderma: A review of case reports and histopathological descriptions

et al. 2023

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Spiny keratoderma (SpK) is a rare skin condition characterized by spine‐like papules on the palms and soles. The condition is identified under several names such as “music box spine keratosis” and “palmoplantar filiform hyperkeratosis,” creating ambiguity in the diagnostic and histopathologic features of the disease. In this study, we reviewed 84 cases of SpK to examine patient demographics, medical history, clinical and histopathological descriptions, and sporadic versus hereditary onset. Notably, the most used histopathological terms were “parakeratosis” and “hypogranulosis,” and the most used clinical terms were “spine” and “hyperpigmented.” The average age at presentation was 60.1 years with the majority of cases in males. Only 29.8% of cases were associated with a family history of SpK and underlying malignancies were present in 28.6% of cases. This review investigates the frequency of histopathologic and clinical terms used to describe SpK to provide insight into the clinical and histopathological characteristics of this rarely reported condition.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Spiny keratoderma: A review of case reports and histopathological descriptions

et al. 2023

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“…Although the development of MM has been linked to patient immunosuppression, few reports to date have described the appearance of MM in subjects with autoimmune disorders and, to our knowledge, existing reports have usually described only individual associations between single autoimmune diseases and MM . Many authors have described these cases as associated diseases, whereas only very few reports have reported patients with both MM and ‘paraneoplastic’ autoimmune disease, namely, dermatomyositis and cerebellar degeneration …”

Section: Discussionmentioning

confidence: 99%

“…patients with both MM and 'paraneoplastic' autoimmune disease, namely, dermatomyositis and cerebellar degeneration. [13][14][15][16][17][18] In 2007, Kaae et al 2 evaluated the effect of six different autoimmune diseases on the incidence and prognosis of MM, and did not find any influence of previous autoimmune disease on MM prognosis in their study. Other groups have also investigated correlations between autoimmune disease and MM, and have found either a negative effect or no significant effect on MM prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association between autoimmune disease and cutaneous melanoma with regard to melanoma prognosis

et al. 2014

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Lasting pathologic complete response to chemotherapy for ovarian cancer after receiving antimalarials for dermatomyositis

Cadena

Werth

et al. 2018

ecancer

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Could hydroxychloroquine and quinacrine antimalarial therapy for dermatomyositis later attributed to a paraneoplasic manifestation of an ovarian cancer enhance its subsequent response to chemotherapy? Five months after being diagnosed with dermatomyositis, while somewhat improved with hydroxychloroquine, quinacrine and methotrexate, this 63-year-old woman presented with an advanced intra-abdominal epithelial ovarian cancer documented (but not resected) at laparotomy. Neoadjuvant carboplatin/paclitaxel resulted in remarkable improvement of symptoms, tumour markers and imaging findings leading to thorough cytoreductive surgery at completion of five cycles. No tumour was found in the resected omentum, gynaecologic organs, as well as hepatic and nodal sampling thus documenting a complete pathologic response; a subcutaneous port and an intraperitoneal (IP) catheter were placed for two cycles of IP cisplatin consolidation. She remains free of disease 3 years after such treatment and her dermatomyositis is in remission in the absence of any treatment. We discuss a possible role of autophagy in promoting tumour cell survival and chemoresistance that is potentially reversed by antimalarial drugs. Thus, chemotherapy following their use may subsequently lead to dramatic potentiation of anticancer treatment.

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Dermatomyositis and Punctate Porokeratotic Keratoderma as Paraneoplastic Syndrome of Ovarian Cancer

Cited by 5 publications

References 9 publications

Spiny keratoderma: A review of case reports and histopathological descriptions

Spiny keratoderma: A review of case reports and histopathological descriptions

Association between autoimmune disease and cutaneous melanoma with regard to melanoma prognosis

Lasting pathologic complete response to chemotherapy for ovarian cancer after receiving antimalarials for dermatomyositis

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