Dermatomyositis Associated with Chronic Myelogenous Leukemia

Abstract

Dermatomyositis and polymyositis have been well established in association with malignant neoplastic disease. Most commonly, this association has been noted in patients with solid tumors rather than in patients with neoplasms of hematopoietic origin. We describe here a patient with chronic myelogenous leukemia who developed typical dermatomyositis, which responded to therapy with corticosteroids. This concurrence has been reported in only one previous patient to our knowledge. The nature and implications of the association of dermatomyositis and neoplasia are discussed.

Heliotrope-like eruption mimicking dermatomyositis in a patient treated with imatinib mesylate for chronic myeloid leukemia

“…In the present case, the eruption of the upper eyelid mimicked the heliotrope rash observed in DM, 9 both clinically and pathologically. Indeed, DM can be associated with hematological malignancies such as CML 10 . However, in our patient, there were neither symptoms nor signs suggesting DM except for the periorbital edema.…”

Paraneoplastic Dermatomyositis in an Adolescent

“…The proportion of this association varies in the literature, between 6 and 41% [2,[9][10][11]. Most frequent are tumors of the stomach, the lungs, the colon, or the breast; tumors of the uterus or the nasopharynx are mentioned in some ethnic groups (China); the associa tion with leukemia is less frequent [12].…”