Dermatomyositis Associated with Pneumomediastinum and Subcutaneous Cellular Tissue Emphysema

Isfer, Roseli Svartman; Nakao, Shigetomi; Cernea, Selma Schuartz

doi:10.1093/rheumatology/33.11.1092

Cited by 14 publications

(15 citation statements)

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“…The risk factors for the pneumomediastinum in patients with DM include interstitial lung disease [4,6], cutaneous vasculopathy [7,9], mild or absent CK elevation [3,7,8], younger age [7] and steroid treatment [6,7]. Our patient was young and his CK levels were within the normal limits when the pneumomediastinum developed.…”

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confidence: 79%

“…There was symmetrical proximal muscle weakness of the limbs. Laboratory ®ndings were as follows: haemoglobin 13.6 gudl, WBC count 10 100umm 3 , ESR 25 mmuh, CK 79 Uul (normal range 16±190), LDH 1450 Uul (normal range 240± 480), AST 48 Uul (normal range 7±39), ALT 128 Uul (normal range 2±40). Tests for ANA, anti-DNA, Sm, RNP, Ro, La and Jo-1 were negative.…”

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confidence: 99%

“…Alternatively, ®brosis itself leads to cyst formation and the rupture of such cysts can result in pneumomediastinum. On the other hand, interstitial ®brosis is not an essential underlying condition for the development of pneumomediastinum, as some cases with pneumomediastinum reported in the literature had no ®ndings of interstitial lung disease [2,3,9].…”

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confidence: 99%

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Pneumomediastinum and subcutaneous emphysema associated with dermatomyositis

Korkmaz¹,

Özkan²,

Akay³

et al. 2001

Rheumatology

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Rheumatology 2001;40:476±478Pneumomediastinum and subcutaneous emphysema associated with dermatomyositis SIR, Dermatomyositis (DM) is a generalized disorder characterized by myositis and typical cutaneous ®nd-ings. The lung is frequently affected, usually by interstitial pneumonitis [1]. Spontaneous pneumomediastinum has also been reported as a rare complication in DM [2± 4]. Here we describe a patient with DM who developed interstitial pneumonitis complicated by pneumomediastinum and subcutaneous emphysema during steroid therapy.A 28-yr-old man was seen in another hospital in December 1999 with complaints of general fatigue, anorexia, fever, symmetrical arthritis of the hands and erythema of the ®ngers and face. Laboratory examination showed haemoglobin 9 gudl, white blood cell (WBC) count 8300umm 3 , erythrocyte sedimentation rate (ESR) 30 mmuh, aspartate transaminase (AST) 93 Uul (normally <37), alanine transaminase (ALT) 49 Uul (normally <42), lactate dehydrogenase (LDH) 1227 Uul (normal range 225± 450), creatine kinase (CK) 287 Uul (normal range 24 ±190). Tests for antinuclear antibodies (ANA), anti-Jo-1 and rheumatoid factor were negative. Electroneuromyography showed myopathic abnormalities; biopsy specimens of the right deltoid muscle revealed degeneration of muscle ®bres and a mild degree of mononuclear cell in®ltration. Chest radiography showed a mild alveolar and interstitial

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Pneumomediastinum and subcutaneous emphysema associated with dermatomyositis

Korkmaz¹,

Özkan²,

Akay³

et al. 2001

Rheumatology

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“…Sin embargo, existen reportes de pacientes que han tenido esta patología sin estar expuestos a corticoides 8 , por lo cual se ha planteado que probablemente esta asociación refleja que quienes realizan Nm espontáneo suelen ser pacientes con enfermedad más severa, y expuestos a terapia más agresiva desde un comienzo 2 . Los factores de riesgo propuestos que predispondrían a los pacientes con DM a desarrollar Nm son la presencia de EPD, de vasculopatía cutánea, el uso previo de corticoides y presentar CK normal al momento del diagnóstico 9 .…”

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Neumomediastino y necrosis cutánea en asociación a dermatomiositis: presentación de un caso clínico y revisión de la literatura

C¹,

L²,

Ibáñez³

2015

Rev. méd. Chile

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“…Spontaneous pneumomediastinum has been reported in a patient with fibrosing alveolitis [4] and in a few patients with pulmonary fibrosis associated with rheumatoid arthritis [5], systemic lupus erythematosus [6], or of unspecified aetiology [7]. From a review of the English and French literature, it appears that 23 cases (excluding ours) of pneumomediastinum associated with polymyositis and dermatomyositis have been reported [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] since it was first described in 1986 [8].…”

Section: Discussionmentioning

confidence: 99%

Persistent Pneumomediastinum and Dermatomyositis: A Case Report and Review of the Literature

et al. 2001

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We describe a 42-year-old man with dermatomyositis and interstitial lung disease who presented with anterior neck pain and dyspnoea. Chest radiographs showed subcutaneous emphysema, pneumomediastinum and diffuse reticulonodular infiltration in both lungs. After the administration of high doses of prednisolone, an improvement of pulmonary function and respiratory symptoms was observed but the pneumomediastinum persists 12 months after diagnosis, and without any complication. We review the cases that have been reported thus far of pneumomediastinum associated with dermatomyositis and discuss the possible mechanisms involved. We conclude that pneumomediastinum is not an uncommon complication of dermatomyositis and that its aetiopathogenesis remains very unclear.

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Dermatomyositis Associated with Pneumomediastinum and Subcutaneous Cellular Tissue Emphysema

Cited by 14 publications

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Pneumomediastinum and subcutaneous emphysema associated with dermatomyositis

Pneumomediastinum and subcutaneous emphysema associated with dermatomyositis

Neumomediastino y necrosis cutánea en asociación a dermatomiositis: presentación de un caso clínico y revisión de la literatura

Persistent Pneumomediastinum and Dermatomyositis: A Case Report and Review of the Literature

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